Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: Disclosed is an autopilot-coupled traffic alert and collision avoidance systems (AP TCAS). The AP TCAS includes a an AP/automatic flight control system (AFCS) that is configured to receive a vertical speed setting after the issuance of a preventive resolution advisory, wherein the aircraft vertical speed setting exceeds the maximum vertical speed allowed by the resolution advisory, the AP/AFCS being further configured to: (1) modify the aircraft vertical speed setting so as to be less than the maximum vertical speed, and relay the modified second aircraft vertical speed to an autopilot system of the aircraft to automatically cause the aircraft to fly at a vertical speed in accordance with the modified second vertical speed setting; and (2) relay a command to the autopilot system to initiate an automatic, corrective flight maneuver if a current vertical speed of the aircraft is within a predetermined amount of the maximum vertical speed.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: Disclosed is an autopilot-coupled traffic alert and collision avoidance systems (AP TCAS). The AP TCAS includes a an AP/automatic flight control system (AFCS) that is configured to receive a vertical speed setting after the issuance of a preventive resolution advisory, wherein the aircraft vertical speed setting exceeds the maximum vertical speed allowed by the resolution advisory, the AP/AFCS being further configured to: (1) modify the aircraft vertical speed setting so as to be less than the maximum vertical speed, and relay the modified second aircraft vertical speed to an autopilot system of the aircraft to automatically cause the aircraft to fly at a vertical speed in accordance with the modified second vertical speed setting; and (2) relay a command to the autopilot system to initiate an automatic, corrective flight maneuver if a current vertical speed of the aircraft is within a predetermined amount of the maximum vertical speed.

Abstract: Disclosed is an autopilot-coupled traffic alert and collision avoidance systems (AP TCAS). The AP TCAS includes a an AP/automatic flight control system (AFCS) that is configured to receive a vertical speed setting after the issuance of a preventive resolution advisory, wherein the aircraft vertical speed setting exceeds the maximum vertical speed allowed by the resolution advisory, the AP/AFCS being further configured to: (1) modify the aircraft vertical speed setting so as to be less than the maximum vertical speed, and relay the modified second aircraft vertical speed to an autopilot system of the aircraft to automatically cause the aircraft to fly at a vertical speed in accordance with the modified second vertical speed setting; and (2) relay a command to the autopilot system to initiate an automatic, corrective flight maneuver if a current vertical speed of the aircraft is within a predetermined amount of the maximum vertical speed.

Abstract: Disclosed is an autopilot-coupled traffic alert and collision avoidance systems (AP TCAS). The AP TCAS includes a an AP/automatic flight control system (AFCS) that is configured to receive a vertical speed setting after the issuance of a preventive resolution advisory, wherein the aircraft vertical speed setting exceeds the maximum vertical speed allowed by the resolution advisory, the AP/AFCS being further configured to: (1) modify the aircraft vertical speed setting so as to be less than the maximum vertical speed, and relay the modified second aircraft vertical speed to an autopilot system of the aircraft to automatically cause the aircraft to fly at a vertical speed in accordance with the modified second vertical speed setting; and (2) relay a command to the autopilot system to initiate an automatic, corrective flight maneuver if a current vertical speed of the aircraft is within a predetermined amount of the maximum vertical speed.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: An article of manufacture having a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in a table. The table selected from the group of tables consisting of TABLES 1S-16S, 1R-17R, and IGV. Wherein X and Y are distances in inches which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z in inches. The profile sections at the Z distances being joined smoothly with one another to form a complete airfoil shape.

Abstract: A turbine bucket airfoil has a conical fillet about the intersection of the airfoil tip and tip shroud having a nominal profile in accordance with coordinate values of X and Y, offset 1, offset 2 and Rho set forth in Table I. The shape parameters of offset 1, offset 2 and Rho define the configuration of the fillet at the specified X and Y locations about the fillet to provide a fillet configuration accommodating high localized stresses. The fillet shape may be parabolic, elliptical or hyperbolic as a function of the value of the shape parameter ratio of D1 D1 + D2 at each X, Y location where D1 is a distance between an intermediate point along a chord between edge points determined by offsets O1 and O2 and a shoulder point on the fillet surface and D2 is a distance between the shoulder point and an apex location at the intersection of the airfoil tip and tip shroud.

Abstract: Third stage turbine buckets have airfoil profiles substantially in accordance with Cartesian coordinate values of X, Y and Z set forth Table I wherein X and Y values are in inches and the Z values are non-dimensional values from 0.03 span to 0.95 span convertible to Z distances in inches by multiplying the Z values by the height of the airfoil in inches. The X and Y values are distances which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form the bucket airfoil shape. The X, Y and Z distances may be scalable as a function of the same constant or number to provide a scaled up or scaled down airfoil section for the bucket. The nominal airfoil given by the X, Y and Z distances lies within an envelop of ±0.150 inches in directions normal to the surface of the airfoil.

Abstract: A turbine stage one bucket has an airfoil having a plurality of cooling holes passing through the airfoil from 0% span to 100% span whereby cooling air exits the airfoil tip into the hot gas path. X and Y coordinate values are given in Table I, locating the holes relative to the airfoil profile at airfoil profile sections of 5%, 50% and 90% span, Table I also giving the hole diameters. In this manner, cooling hole optimization for this turbine bucket airfoil is achieved. The cooling holes are also located in relation to the profile of the bucket airfoil given by the X, Y and Z coordinate values of Table II, the two coordinate systems having the same origin.

Abstract: A turbine bucket includes a bucket airfoil having a tip shroud with leading and trailing edges defining leading and trailing edge profiles substantially in accordance with Cartesian coordinate values of X and Y at points 12-20 and 1-11, respectively, set forth in Table I. The X and Y values are distances in inches which, when respective points 12-20 and 1-11 are connected by smooth, continuing arcs, define the leading and trailing edge tip shroud profiles. An airfoil profile at 95% span is defined by Cartesian coordinate values of X, Y and Z in Table II having the same X, Y origin along the radial Z axis as the origin of Table I. The profiled leading and trailing edges of the tip shroud relative to the airfoil profile afford optimum tip shroud mass distribution which maximizes creep life of the bucket. Stage efficiency is also improved by providing a tip shroud covering the airfoil throat.