Abstract: The present invention relates to pharmaceutical compositions containing the antifolate aminopterin, processes for making the compositions, and methods of using them to treat disorders in adult and pediatric patients. Pharmaceutical compositions substantially free of impurities are provided comprising a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof. Relative to the teachings of the prior art, the disclosed methods and compositions provide unexpected improvements that include a greater interpatient oral bioavailability in pediatric patients, a smaller interpatient coefficient of variation of oral bioavailability, a smaller mean intrapatient coefficient of variation of oral bioavailability, a greater therapeutic index, a smaller coefficient of variation of toxicity, efficacy in combination therapy, and efficacy of certain polyglutamated metabolites.

Abstract: The present invention relates to the use, for adhesion on hair or fiber-populated surfaces, of hydrogel adhesive characterized by a G?25, (1 rad/sec) or below 1000 Pa, resulting in embedding of the hair of fiber and good adhesion properties on the surface. The invention also encompasses Personal Care Products and Surface Care Articles containing the hydrogel compositions herein.

Abstract: A system is disclosed for secure communication between an interrogator and an RFID tag. The system includes means for singulating the tag in a population of RFID tags and means for extracting from the tag, identity data adapted to uniquely identify the tag. The system further includes means for securely communicating the identity data to a secure database, means for providing authentication data by the database and means for securely communicating the authenticating data to the interrogator. The system also includes means for providing a further communication between the tag and the interrogator, and wherein at least one stream of data between the tag and the interrogator includes random data generated via a random physical process. The tag and database may each include means for maintaining a count of secure authentications. The count may be separately maintained by the tag and database and may be incremented following each secure authentication.

Abstract: An Object Instruction Language (OIL) provides a method for recording macros in a computer language independent syntax so that the macro can be converted into the source code of multiple computer languages without having to re-record the macro or translate the macro from the recorded language to an alternate language, thereby reducing the time needed to create macros for multiple computer languages, reducing the likelihood of error inherent in repeating a single task multiple times, and providing users of the software with an opportunity to record macros in the users' preferred language.

Abstract: A faecal management device has a bag and a flange. The faecal management device is placed on a wearer, in combination with an applicator. The applicator is configured to exert pressure from at least two spaced apart pressure points onto the flange of the device. The device is placed on a wearer by using placement lobes associated with the flange.

Abstract: The present invention relates to the use, for adhesion on hair or fiber-populated surfaces, of hydrogel adhesive characterized by a G′25, (1 rad/sec) below 1000 Pa, and containing weak acid monomer units at selected degree of neutralization, not only resulting in embedding of the hair or fiber and good adhesion properties on the surface, but also in excellent results in terms of cohesiveness, and peel force.

Abstract: A disposable human waste management device, such as faecal and urine management devices (10), which are provided with adhesives for attachment of the device to the skin. Such adhesives (20) provide secure attachment and are pleasing to the skin upon application, yet cause no discomfort upon removal. The device may also be used in combination with a disposable diaper.

Abstract: The present invention relates to the use, for adhesion on hair or fiber-populated surfaces, of hydrogel adhesive characterized by a G′25, (1 rad/sec) or below 1000 Pa, resulting in embedding of the hair of fiber and good adhesion properties on the surface.

Abstract: The present invention relates to disposable absorbent articles such as diapers and sanitary napkins which are provided with adhesives for attachment of the article to the skin which adhesives provide secure attachment and are pleasing to the skin upon application, yet cause no discomfort upon removal.

Abstract: A disposable article having a sensor that predicts an impending event such as an elimination of bodily waste. The article may also include an actuator that performs a responsive function when the sensor predicts the impending event.

Abstract: A biofeedback device for predicting an impending elimination of bodily waste in an incontinent person includes a sensing element in contact with an area of a user so as to detect electrical activity of a sphincter muscle associated therewith and a signaling element operatively connected to the sensing element that provides a signal upon an occurrence of a predetermined electrical activity for the sphincter muscle. The biofeedback device is able to predict an impending elimination of bodily waste for an incontinent person, as well as assist the incontinent person in achieving a contraction of his/her sphincter muscle.

Abstract: This invention relates to a urine management device (10) comprising a bag (11) and a flange (12). The flange (12) comprises adhesive (20) used to attach the device (10) to the uro-genital area of the wearer. The invention resides principally in providing an optimised shape of the aperture (21) of said device (10). One preferred embodiment of the invention is an aperture (21) whose contour is defined by one ellipse in the longitudinal direction, the longitudinal diameter of said ellipse being 2.25 times greater than the transversal diameter.

Abstract: A faecal management device having a flange or abutting the perianal region of a wearer. The flange has an aperture therethrough. The aperture has a contour defined by two mutually perpendicularly oriented ellipses.

Abstract: A disposable article to be fitted to a wearer having an external anal sphincter muscle, the external anal sphincter muscle having a basal electrical activity. The disposable article preferably comprises a sensor or sensor system operatively connected to the article wherein the sensor is adapted to detect changes in the electrical activity of the wearer's external anal sphincter muscle that correlates to an impending elimination of bodily waste and to provide a signal to the wearer, a caregiver or an element of the article notifying the wearer, caregiver or element of the article of the impending event.

Abstract: A disposable article to be fitted to a wearer. The disposable article preferably comprises a sensor operatively connected to the article. The sensor is adapted to detect electrical activity in the wearer's smooth colonic muscles, abdominal muscles or the muscles surrounding the bladder or rectum which correlates to an impending elimination of bodily waste and to provide a signal to the wearer, a caregiver or an element of the article of the impending event.

Abstract: The present invention relates to topical adhesives used for the attachment of articles to the skin. The topical adhesive provides secure attachment and is pleasing to the skin upon application, yet causes no discomfort and a low level of adhesive residue on the skin upon removal. The topical adhesive is selected to have rheological characteristics determined by the relationship between the elastic modulus G′ and the viscous modulus G″.

Abstract: The present invention relates to topical adhesives used for the attachment of articles to the skin. The topical adhesive provides secure attachment and is pleasing to the skin upon application, yet causes no discomfort and a low level of adhesive residue on the skin upon removal. The topical adhesive is selected to have rheological characteristics determined by the relationship between the elastic modulus G′ and the viscous modulus G″.

Abstract: A biofeedback device for predicting an impending elimination of bodily waste in an incontinent person includes a sensing element in contact with an area of a user so as to detect electrical activity of a sphincter muscle associated therewith and a signaling element operatively connected to the sensing element that provides a signal upon an occurrence of a predetermined electrical activity for the sphincter muscle. The biofeedback device is able to predict an impending elimination of bodily waste for an incontinent person, as well as assist the incontinent person in achieving a contraction of his/her sphincter muscle.

Abstract: A biofeedback device for predicting an impending elimination of bodily waste in an incontinent person includes a sensing element in contact with an area of a user so as to detect electrical activity of a sphincter muscle associated therewith and a signaling element operatively connected to the sensing element that provides a signal upon an occurrence of a predetermined electrical activity for the sphincter muscle. The biofeedback device is able to predict an impending elimination of bodily waste for an incontinent person, as well as assist the incontinent person in achieving a contraction of his/her sphincter muscle.

Abstract: The present invention relates to a combination of a substrate with combinations for attachment to the skin. In particular the present invention relates to a combination of a substrate which can be employed for attachment to the skin of articles such as protective articles, clothing, prosthesis, heat wraps, pads, and/or packs, cold wraps hearing, protective face masks, ornamental articles or eye wear, or also of functional articles such as cosmetic or pharmaceutical delivery articles that provide a substance to the skin. The combination provides secure attachment and is pleasing to the skin upon application, yet causes no discomfort upon removal. This is achieved by selecting the chemical composition and heological characteristics of the combinations and the physical characteristics of the substrate on which the combination is applied.