Patents by Inventor Peter Colosi

Peter Colosi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AAV CAPSID COMPOSITIONS AND METHODS FOR DELIVERY
    Publication number: 20250122530
    Abstract: The disclosure provides various compositions comprising novel adeno-associated virus (AAV) capsid sequences and functional fragments thereof. Also provided, are methods of delivery, treatment and manufacture using the compositions provided by the disclosure.
    Type: Application
    Filed: September 2, 2022
    Publication date: April 17, 2025
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Peter COLOSI, Vincent LEONARD, Silvia RAMIREZ, Justin ISHIDA, Yu-Shan TSENG, Teague STERLING
  • TREATMENT OF HEREDITARY ANGIOEDEMA WITH AAV GENE THERAPY VECTORS AND THERAPEUTIC FORMULATIONS
    Publication number: 20240408240
    Abstract: Provided herein are pharmaceutical compositions and methods for treating hereditary angioedema in a human subject.
    Type: Application
    Filed: September 30, 2022
    Publication date: December 12, 2024
    Inventors: Peter COLOSI, JooChaun ANG, Saeed MOSHASHAEE, Stephanie VARGAS, Thomas MACHING, Jack BROWNRIGG, Lawrence Mason SHIH, Iris CHEN, Heather Ann WENZEL
  • AAV CAPSID COMPOSITIONS AND METHODS FOR DELIVERY
    Publication number: 20240384242
    Abstract: The disclosure provides various compositions comprising novel adeno-associated virus (AAV) capsid sequences and functional fragments thereof. Also provided, are methods of delivery, treatment and manufacture using the compositions provided by the disclosure.
    Type: Application
    Filed: September 2, 2022
    Publication date: November 21, 2024
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Peter COLOSI, Vincent LEONARD, Silvia RAMIREZ, Justin ISHIDA, Yu-Shan TSENG, Teague STERLING
  • AAV CAPSID COMPOSITIONS AND METHODS FOR DELIVERY
    Publication number: 20240376495
    Abstract: The disclosure provides various compositions comprising novel adeno-associated virus (AAV) capsid sequences and functional fragments thereof. Also provided, are methods of delivery, treatment and manufacture using the compositions provided by the disclosure.
    Type: Application
    Filed: September 2, 2022
    Publication date: November 14, 2024
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Peter COLOSI, Vincent LEONARD, Silvia RAMIREZ, Justin ISHIDA, Yu-Shan TSENG, Teague STERLING
  • AAV CAPSID COMPOSITIONS AND METHODS FOR DELIVERY
    Publication number: 20240376496
    Abstract: The disclosure provides various compositions comprising novel adeno-associated virus (AAV) capsid sequences and functional fragments thereof. Also provided, are methods of delivery, treatment and manufacture using the compositions provided by the disclosure.
    Type: Application
    Filed: September 2, 2022
    Publication date: November 14, 2024
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Peter COLOSI, Vincent LEONARD, Silvia RAMIREZ, Justin ISHIDA, Yu-Shan TSENG, Teague STERLING
  • METHODS OF REDOSING GENE THERAPY VECTORS
    Publication number: 20240200096
    Abstract: The present disclosure relates, in general, to methods for readministering, or redosing, a subject having undergone a first gene therapy regimen with a second, or subsequent, administration of a gene therapy regimen, wherein the first gene therapy vector and second gene therapy vector comprise different AAV capsids but carry a transgene or polynucleotide useful to treat the same disease or disorder.
    Type: Application
    Filed: October 2, 2023
    Publication date: June 20, 2024
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Peter COLOSI, Justin ISHIDA, Silvia RAMIREZ
  • TREATMENT OF HEREDITARY ANGIOEDEMA WITH LIVER-SPECIFIC GENE THERAPY VECTORS
    Publication number: 20230340078
    Abstract: Provided herein are compositions and methods for treating a Cl esterase inhibitor deficiency by normalizing levels of the Cl esterase inhibitor protein in a subject having HAE.
    Type: Application
    Filed: November 13, 2020
    Publication date: October 26, 2023
    Inventor: Peter COLOSI
  • Methods of treating phenylketonuria
    Patent number: 11739345
    Abstract: Provided herein are methods of treating phenylketonuria by normalizing levels of amino acids, neurotransmitters, and neurotransmitter metabolites in a subject having phenylketonuria.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: August 29, 2023
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Geoffrey Berguig, Rajeev Mahimkar, Hassibullah Akeefe, Peter Colosi
  • VIRUS-FREE CELL CULTURES
    Publication number: 20230075854
    Abstract: The invention is directed to methods of removing adventitious virus from cells and cell lines and virus-free cells and cell lines obtainable by such methods.
    Type: Application
    Filed: February 9, 2021
    Publication date: March 9, 2023
    Inventors: Michael LOCHRIE, Peter COLOSI, Barrie CARTER, Tomas CINEK
  • METHODS OF REDOSING GENE THERAPY VECTORS
    Publication number: 20200362368
    Abstract: The present disclosure relates, in general, to methods for readministering, or redosing, a subject having undergone a first gene therapy regimen with a second, or subsequent, administration of a gene therapy regimen, wherein the first gene therapy vector and second gene therapy vector comprise different AAV capsids but carry a transgene or polynucleotide useful to treat the same disease or disorder.
    Type: Application
    Filed: May 13, 2020
    Publication date: November 19, 2020
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Peter COLOSI, Justin ISHIDA, Silvia RAMIREZ
  • METHODS OF TREATING PHENYLKETONURIA
    Publication number: 20190376081
    Abstract: Provided herein are methods of treating phenylketonuria by normalizing levels of amino acids, neurotransmitters, and neurotransmitter metabolites in a subject having phenylketonuria.
    Type: Application
    Filed: May 8, 2019
    Publication date: December 12, 2019
    Inventors: Geoffrey Berguig, Rajeev Mahimkar, Hassib Akeefe, Peter Colosi
  • High-efficiency wild-type-free AAV helper functions
    Patent number: 7851195
    Abstract: The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: December 14, 2010
    Assignee: Genzyme Corporation
    Inventor: Peter Colosi
  • High-efficiency wild-type-free AAV helper functions
    Publication number: 20090017542
    Abstract: The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods.
    Type: Application
    Filed: June 20, 2008
    Publication date: January 15, 2009
    Inventor: Peter Colosi
  • AAV virions with decreased immunoreactivity and uses therefor
    Publication number: 20080008690
    Abstract: Methods of making and using recombinant AAV virions with decreased immunoreactivity are described. The recombinant AAV virions include mutated capsid proteins or are derived from non-primate mammalian AAV serotypes and isolates that display decreased immunoreactivity relative to AAV-2.
    Type: Application
    Filed: July 9, 2007
    Publication date: January 10, 2008
    Inventors: Alejandra Arbetman, Peter Colosi, Michael Lochrie, Richard Surosky
  • Polynucleotides for use in recombinant adeno-associated virus virion production
    Publication number: 20070026521
    Abstract: Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producing rAAV virions are also provided. The methods can be practiced to produce commercially significant levels of rAAV particles without also generating significant levels of infectious helper virus or other contaminating by-products.
    Type: Application
    Filed: October 13, 2006
    Publication date: February 1, 2007
    Applicant: Genzyme Corporation
    Inventor: Peter Colosi
  • Polynucleotides for use in recombinant adeno-associated virus virion production
    Patent number: 7125705
    Abstract: Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producing rAAV virions are also provided. The methods can be practiced to produce commercially significant levels of rAAV particles without also generating significant levels of infectious helper virus or other contaminating by-products.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: October 24, 2006
    Assignee: Genzyme Corporation
    Inventor: Peter Colosi
  • High-efficiency wild-type-free AAV helper functions
    Publication number: 20060094116
    Abstract: The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods.
    Type: Application
    Filed: November 18, 2005
    Publication date: May 4, 2006
    Applicant: Avigen, Inc.
    Inventor: Peter Colosi
  • High-efficiency wild-type-free AAV helper functions
    Patent number: 7037713
    Abstract: The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: May 2, 2006
    Assignee: Avigen, Inc.
    Inventor: Peter Colosi
  • AAV virions with decreased immunoreactivity and uses therefor
    Publication number: 20060051333
    Abstract: Methods of making and using recombinant AAV virions with decreased immunoreactivity are described. The recombinant AAV virions include mutated capsid proteins or are derived from non-primate mammalian AAV serotypes and isolates that display decreased immunoreactivity relative to AAV-2.
    Type: Application
    Filed: June 21, 2004
    Publication date: March 9, 2006
    Inventors: Alejandra Arbetman, Peter Colosi, Michael Lochrie, Richard Surosky
  • High-efficiency AAV helper functions
    Publication number: 20060003453
    Abstract: The present invention provides methods and compositions for producing high titer preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include AAV helper function systems and host cells. The present invention also includes methods of using AAV helper function vectors that effect the production of only small amounts of the long forms of Rep protein, and rAAV virions produced by such methods.
    Type: Application
    Filed: September 8, 2005
    Publication date: January 5, 2006
    Applicant: Avigen, Inc.
    Inventors: Georges Natsoulis, Gary Kurtzman, Peter Colosi