Abstract: A multi-directional vent limiter includes a vent body including a lower vent body and an upper vent body. The lower vent body defines an inner chamber and an inlet port in communication with the inner chamber, and the upper vent body defines a first vent hole and a second vent hole. The upper vent body is rotatably disposed on the lower vent body, such that the first vent hole and the second vent hole are in communication with the inner chamber. The multi-directional vent limiter further includes a plug configured to be selectively insertable into one of the first vent hole and the second vent hole so as to hermetically seal one of the first vent hole and the second vent hole and allow another of the first vent hole and the second vent hole open to vent.

Abstract: This invention relates to polymorphisms in the human mGluR8, in particular to the discovery of 10 single nucleotide polymorphisms in the mGluR8 gene. The invention also relates to methods and materials for analyzing allelic variation in the mGluR8 gene, and to the use of mGluR8 polymorphism in the diagnosis and treatment of mGluR8 and/or mGluR8-mediated diseases, such as Parkinson s disease etc. The herein disclosed probes containing at least one of the herein disclosed SNPs can be used to identify nucleic acid samples containing mGluR8 SNPs or as primers or for expressing variant proteins. Methods of analyzing the polymorphic forms occupying the polymorphic sites are also disclosed.