Abstract: The present disclosure provides devices, systems, methods for processing and/or analyzing a biological sample. An analytic device for processing and/or analyzing one or more biological samples may be electronically and/or physically configured or programed to activate one or more features/operations of the analytic device. The analytic device can be configured or programed by one or more instructions received from a cooperating electronic device or a remote server. The analytic device may comprise a moving carriage. The analytic device may be portable. The analytic device may receive instructions for performing an assay from a mobile electronic device external to a housing of the analytic device.

Abstract: Exemplary embodiments are directed to wireless charging and wireless power alignment of wireless power antennas associated with a vehicle. A wireless power charging apparatus includes an antenna including first and second orthogonal magnetic elements for detecting a horizontal component of a magnetic field generated from a second charging base antenna. A processor determines a directional vector between the antennas.

Abstract: Method, apparatus, and systems for roll angle estimation for an input/gesture device (IGD) are disclosed. The method includes estimating a first axis vector of the input/gesture device (IGD) relative to the surface of the mobile device (MD), as a first frame of reference, using readings from a first type of sensor; and estimating the first axis vector of the IDG relative to a different, second frame of reference using a gyroscope integration of readings from the 3-axis gyroscope. The method further includes aligning the first axis vector of the IDG in the first frame of reference with the first axis vector of the IDG in the second frame of reference; minimizing a change in the alignment of the first axis vectors between the first frame of reference and the second frame of reference; and determining the roll angle of the IDG relative to the surface of the MD.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Exemplary embodiments are directed to wireless charging and wireless power alignment of wireless power antennas associated with a vehicle. A wireless power charging apparatus includes an antenna including first and second orthogonal magnetic elements for detecting a horizontal component of a magnetic field generated from a second charging base antenna. A processor determines a directional vector between the antennas.

Abstract: A system and method provide gasless, mechanized, field welding of an exterior of a tubular structure such as a pipeline, without the need for an enclosure. An embodiment consolidates some of the welding equipment on a skid for ease of transport to and from a remote worksite. The gasless weld may be achieved despite the presence of wind, by precisely controlling an arc voltage as disclosed. The footprint and weight of the system may be minimized, along with the associated labor, expense, and environmental impact otherwise incurred by conventional welding techniques using enclosures.

Abstract: Some embodiments of the compositions and methods disclosed herein include gene-edited, artificial immunoregulatory T cells (airT cells) comprising a constitutively expressed FoxP3 gene product expressed at a level equal to or greater than the level of FoxP3 expression in natural T regulatory (Treg or suppressor T) cells, and a transduced (e.g., artificially engineered by gene editing, viral vector transduction, transfection or other genetic engineering methodologies) T cell receptor (TCR). In some embodiments, the TCR is preferably specific for an antigen associated with an autoimmune, allergic, or other inflammatory condition. Some embodiments include methods for the preparation and/or use of airT cells. Some such embodiments include use of airT cells for the treatment and/or amelioration of a disorder, in which antigen-specific immunosuppression may be beneficial, such as an autoimmune, allergic, or other inflammatory disorder.

Abstract: A printing apparatus for printing a three-dimensional object, including an operative surface; a printing head comprising a frame attached pivotally to at least one control arm, wherein the frame is rotatable about an axis disposed at a point of attachment between the frame and control arm; a plurality of powder dispensers connected at a plurality of positions along the frame, the powder dispensers being configured to deposit multiple layers of powder onto the operative surface simultaneously when the printing head travels relative to the operative surface; and an energy source for emitting at least one energy beam onto at least one layer of powder.

Abstract: An insect trap comprising a trap shell having a first open end opposite a second open end and defining a trap interior having a triangular prism shape; a hanger for suspending the trap shell from an object, wherein a portion of the hanger extends into the trap interior; and an insect lure device suspended within the trap interior, the insect lure device comprising a lure wafer and a flexible container enclosing the lure wafer, wherein the lure wafer comprises an insect attractant chemical incorporated in a solid substrate such that, in a first stage, the insect attractant chemical controllably evaporates to a gaseous state into the flexible container, and wherein the flexible container is gas-permeable such that, in a second stage, the insect attractant chemical in the gaseous state passes through the flexible container into the trap interior.

Abstract: Filters for use in conjunction with valves of the faucet or spigot type, and to filters for use in devices for withdrawing liquids from containers at relatively low pressures, such as gravity feed jugs or other gravity feed reservoirs. A ¼-turn attachment scheme for connecting a filter cartridge to a gravity feed reservoir, such as within a beverage making/dispensing device.

Abstract: Filters for use in conjunction with valves of the faucet or spigot type, and to filters for use in devices for withdrawing liquids from containers at relatively low pressures, such as gravity feed jugs or other gravity feed reservoirs. A ¼-turn attachment scheme for connecting a filter cartridge to a gravity feed reservoir, such as within a beverage making/dispensing device.

Abstract: The invention provides a method for preparing a hydrogel from a hydrophilic polymer having one or more functional groups which are capable of co-reacting in a condensation reaction which method comprises the steps of: (i) preparing a solution of the polymer; (ii) heating the solution to a temperature sufficient for the condensation reaction to take place for a period of time sufficient for the hydrogel to cross-link wherein where the hydrophilic polymer comprises a first and a second hydrophilic polymer, step (i) comprises a step of mixing the hydrophilic polymers to prepare a homogeneous intimate mixture of the polymers; and wherein the heating step (ii) is carried out at a pressure greater than atmospheric pressure. The method of the invention is advantageous because it is relatively low cost, it is a safer procedure with less health & safety concerns, it is carried out in a liquid state and is not limited by film thickness.

Abstract: A computer implemented method of assigning responsibility for multi-sourced technology based services, the method including the steps of: defining a plurality of service delivery functions, defining collections of services that are to be provided by several service providers, providing metrics associating the service delivery functions with the collections of services, and inserting the metrics into a model to indicate which service providers are assigned responsibility for the service delivery functions.

Abstract: An integrated circuit including a pipeline and a method of operating the pipeline. Each stage of the pipeline is triggered by one or more triggering events and are individually, and selectively, stalled by a stall signal. For each stage a stall signal, delayed with respect to the stall signal of a downstream stage, is generated and used to select whether the pipeline stage in question is triggered. A data valid signal propagating with valid data adds further selection, such that only stages with valid data are stalled.

Abstract: An integrated circuit including a pipeline and a method of operating the pipeline. Each stage of the pipeline is triggered by one or more triggering events and are individually, and selectively, stalled by a stall signal. For each stage a stall signal, delayed with respect to the stall signal of a downstream stage, is generated and used to select whether the pipeline stage in question is triggered. A data valid signal propagating with valid data adds further selection, such that only stages with valid data are stalled.

Abstract: An integrated circuit including a pipeline and a method of operating the pipeline. Each stage of the pipeline is triggered by one or more triggering events and are individually, and selectively, stalled by a stall signal. For each stage a stall signal, delayed with respect to the stall signal of a downstream stage, is generated and used to select whether the pipeline stage in question is triggered. A data valid signal propagating with valid data adds further selection, such that only stages with valid data are stalled.

Abstract: A computerized method (and structure) of implementing a business-to-business (B2B) boarding process includes providing a set of questions related to the B2B boarding process to a new business to be boarded into an existing B2B system.

Abstract: Brut polishing of superhard materials to remove positive asperities by use of pressure and heat.

Abstract: The invention relates to a method and apparatus for analyzing fluid flow while considering heat transfer effects and, in particular, a phase change from a molten state to a solid state. In particular, the method and apparatus may be applied to the analysis of an injection molding process for producing a molded polymer component from a thermoplastic or a thermosetting polymer. In one embodiment, the method may be used to determine pressure required to fill a mold cavity and pressure gradients introduced during filling and packing of the cavity of an injection mold. The results of these analyses may be used to determine the number and location of gates, to determine the best material for the component, and to optimize the process conditions used in the molding process.

Abstract: Leakage current control devices include a circuit having one or more functions in a data path where the functions are executed in a sequence. Each of the functions has power reduction logic to energize each respective function. A leakage control circuit interacts with the power reduction logic, so that the functions are energized or deenergized in a control sequence such that the functions where the data is resident are energized and at least one of the other functions is not energized.