Abstract: To automate time series forecasting machine learning pipeline generation, a data allocation size of time series data may be determined based on one or more characteristics of a time series data set. The time series data may be allocated for use by candidate machine learning pipelines based on the data allocation size. Features for the time series data may be determined and cached by the candidate machine learning pipelines. Predictions of each of the candidate machine learning pipelines using at least the one or more features may be evaluated. A ranked list of machine learning pipelines may be automatically generated from the candidate machine learning pipelines for time series forecasting based upon evaluating predictions of each of the one or more candidate machine learning pipelines.

Abstract: The present disclosure is directed to combinations of MetAP2 inhibitors and CDK4/6 inhibitors for the treatment and prevention of cancer.

Abstract: The present disclosure relates to modified or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating, or ameliorating at least one symptom of, metabolic dysfunction associated with a treatment in a subject having cancer. The present disclosure also relates to methods of treating, or ameliorating at least one symptom of, cancer comprising administering a combination of a polymer conjugated MetAP2 inhibitors and at least one second agent.

Abstract: A bucket and a corresponding bucket elevator, the bucket has a bucket wall surrounding a filling and discharge opening and having a rear wall and a front bucket wall, the front bucket wall having a front edge delimiting the filling and discharge opening, and the bucket being connectable to a conveyor device via the rear wall, wherein the ratio between the bucket depth, which corresponds to the horizontal distance between the rear wall and the front edge, and the bucket height, which corresponds to the vertical distance between a bucket low point and the front edge, is greater than 1, preferably greater than 1.3, more preferably greater than 1.5.

Abstract: The present disclosure relates to small molecule or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating, or ameliorating at least one symptom of metabolic dysfunction associated with a treatment in a subject having a disease, such as cancer. The present disclosure also relates to methods of treating, or ameliorating at least one symptom of cancer comprising administering a combination of a polymer conjugated MetAP2 inhibitors and at least one second agent wherein the second agent may induce metabolic dysfunction.

Abstract: The present disclosure relates to modified or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating metabolically-driven diseases and disorders, such as certain cancers.

Abstract: The present disclosure relates to modified or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating metabolically-driven diseases and disorders, such as certain cancers.

Abstract: A bucket and a corresponding bucket elevator, the bucket has a bucket wall surrounding a filling and discharge opening and having a rear wall and a front bucket wall, the front bucket wall having a front edge delimiting the filling and discharge opening, and the bucket being connectable to a conveyor device via the rear wall, wherein the ratio between the bucket depth, which corresponds to the horizontal distance between the rear wall and the front edge, and the bucket height, which corresponds to the vertical distance between a bucket low point and the front edge, is greater than 1, preferably greater than 1.3, more preferably greater than 1.5.

Abstract: A channel sharing method includes receiving a signal in a frequency band. The frequencies in the signal above a cutoff frequency are filtered to generate a filtered signal. The cutoff frequency is determined based on a frequency region that includes a plurality of frequency bands. The filtered signal is amplified using a mixer-tuned low noise amplifier (LNA). The mixer-tuned LNA includes a passive switching mixer and an LNA. The passive switching mixer presents a tunable impedance to the LNA. The LNA provides a voltage gain to the passive switching mixer. The voltage gain being proportional to the tunable impedance.

Abstract: Smart sensors comprising one or more microelectromechanical systems (MEMS) sensors and a digital signal processor (DSP) in a sensor package are described. An exemplary smart sensor can comprise a MEMS acoustic sensor or microphone and a DSP housed in a package or enclosure comprising a substrate and a lid and a package substrate that defines a back cavity for the MEMS acoustic sensor or microphone. Provided implementations can also comprise a MEMS motion sensor housed in the package or enclosure. Embodiments of the subject disclosure can provide improved power management and battery life from a single charge by intelligently responding to trigger events or wake events while also providing an always on sensor that persistently detects the trigger events or wake events. In addition, various physical configurations of smart sensors and MEMS sensor or microphone packages are described.

Abstract: A modular bone fixation linkage includes a plurality of interconnected links that can angulate with respect to an adjacent one of the links in-plane or out-of-plane. The links can further include fixation holes that are configured to receive fixation members that secure the links to an underlying anatomical structure.

Abstract: A modular bone fixation linkage includes a plurality of interconnected links that can angulate with respect to an adjacent one of the links in-plane or out-of-plane. The links can further include fixation holes that are configured to receive fixation members that secure the links to an underlying anatomical structure.

Abstract: The present disclosure relates to modified or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating metabolically-driven diseases and disorders, such as certain cancers.

Abstract: Smart sensors comprising one or more microelectromechanical systems (MEMS) sensors and a digital signal processor (DSP) in a sensor package are described. An exemplary smart sensor can comprise a MEMS acoustic sensor or microphone and a DSP housed in a package or enclosure comprising a substrate and a lid and a package substrate that defines a back cavity for the MEMS acoustic sensor or microphone. Provided implementations can also comprise a MEMS motion sensor housed in the package or enclosure. Embodiments of the subject disclosure can provide improved power management and battery life from a single charge by intelligently responding to trigger events or wake events while also providing an always on sensor that persistently detects the trigger events or wake events. In addition, various physical configurations of smart sensors and MEMS sensor or microphone packages are described.

Abstract: Smart sensors comprising one or more microelectromechanical systems (MEMS) sensors and a digital signal processor (DSP) in a sensor package are described. An exemplary smart sensor can comprise a MEMS acoustic sensor or microphone and a DSP housed in a package or enclosure comprising a substrate and a lid and a package substrate that defines a back cavity for the MEMS acoustic sensor or microphone. Provided implementations can also comprise a MEMS motion sensor housed in the package or enclosure. Embodiments of the subject disclosure can provide improved power management and battery life from a single charge by intelligently responding to trigger events or wake events while also providing an always on sensor that persistently detects the trigger events or wake events. In addition, various physical configurations of smart sensors and MEMS sensor or microphone packages are described.

Abstract: The present disclosure concerns devices and methods for resistance welding sandwich sheets to other components. Many sandwich sheets include a thermoplastic material layer disposed between two metallic cover layers. The sandwich sheet and the other component may be secured relative to one another by a clamping arrangement. A region of the sandwich sheet to be welded may be heated by a preheating current to soften and displace the thermoplastic material layer when the cover layers are pressed together. With respect to the preheating current, a first electrode arrangement may at least temporarily contact an electrically conductive contacting region of the clamping arrangement such that the preheating current can flow via the clamping arrangement. The cover layers may be welded to the other component with a welding current via the first welding electrode of the first electrode arrangement and a second welding electrode of a second electrode arrangement.

Abstract: The present disclosure relates to modified or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating metabolically-driven diseases and disorders, such as certain cancers.

Abstract: The present disclosure relates to small molecule or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating, or ameliorating at least one symptom of metabolic dysfunction associated with a treatment in a subject having a disease, such as cancer. The present disclosure also relates to methods of treating, or ameliorating at least one symptom of cancer comprising administering a combination of a polymer conjugated MetAP2 inhibitors and at least one second agent wherein the second agent may induce metabolic dysfunction.