Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.

Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.

Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.

Abstract: This disclosure relates to CB1 receptor antigen-binding proteins, e.g. antibodies and methods of using the CB1 receptor antibodies. The CB1 receptor antibodies may comprise an antagonistic antibody to CB1 receptors and may be used to treat various health conditions. The health conditions can comprise obesity or diabetes or any disease that benefits from antagonism of the CB1 receptor.

Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.

Abstract: This disclosure relates to CB1 receptor antigen-binding proteins, e.g. antibodies and methods of using the CB1 receptor antibodies. The CB1 receptor antibodies may comprise an antagonistic antibody to CB1 receptors and may be used to treat various health conditions. The health conditions can comprise obesity or diabetes or any disease that benefits from antagonism of the CB1 receptor.

Abstract: A scanning imaging apparatus comprises an optical system including a curved polariser/reflector, a rotatable reflector, a polarisation twisting plate, and a receiver array, wherein a convex reflective element is incorporated in the optical path that acts as a sub-reflector that increases the optical system focal length. It has been found that an increase to the optical focal length in this manner gives a greater 3 dB spot size at the image plane, thus easing design constraints on the receiver array packing density, whilst maintaining a given spatial sampling interval. An additional benefit is that radiation from differing scan locations diverges as it approaches the image plane, which provides more volume in which to position receiver electronics. Focussing of the optical system may be achieved by movement of the sub-reflector.

Abstract: An improved millimetre wave illumination system includes at least one primary source of millimetre wave radiation, a reflecting surface and a baffle comprising a plurality of exit apertures arranged such that at least some of the radiation from the source is reflected from the reflective surface before proceeding to the baffle, characterised in that means are incorporated for generating a plurality of radiation field states within a pre-determined time interval. The baffle, source and reflector are preferably packaged into a container with the exit apertures providing an illumination output. The generation of the plurality of radiation field states provides an illumination at the illuminator output that is less spatially variable when integrated over the pre-determined time interval.

Abstract: A millimetre wave imaging apparatus and method capable of identifying the presence of relatively thin dielectric materials is disclosed. The method involves taking a plurality of millimetre wave images of a scene at different frequencies and analysing the images at different frequencies to look for frequency dependent effects in the scene. Relatively thin dielectric materials can lead to interference effects which can be detected. In one embodiment the imaging apparatus comprises a millimetre wave imager (2) connected to a processor (16) and at least one variable frequency illumination source (22a . . . d, 24a . . . d). The or each illumination source sweeps the illumination frequency across a reasonably wide bandwidth and the imager captures radiation returned from the scene at a number of different illuminating frequencies.

Abstract: Apparatus for scanning a moving object includes a visible waveband sensor 12 oriented to collect a series of images of the object as it passes through a field of view 16. An image processor 14 uses the series of images to form a composite image. The image processor 14 stores image pixel data for a current image and a predecessor image in the series. It uses information in the current image and its predecessor to analyse images and derive likelihood measures indicating probabilities that current image pixels correspond to parts of the object. The image processor 14 estimates motion between the current image and its predecessor from likelihood weighted pixels. It generates the composite image from frames positioned according to respective estimates of object image motion. Image motion may alternatively be detected by a speed sensor such as a Doppler radar 200 sensing object motion directly and providing image timing signals.

Abstract: A radiation detection apparatus comprises a radiation detector and a lens arrangement. The lens arrangement comprises a polarising element and an optical corrector. The optical corrector is preferably located between the polarising element and the radiation detector and has at least one surface designed to correct optical aberrations present in the lens arrangement. The optical corrector may be arranged to provide a mechanical support to the polarising element. The optical corrector is arranged to increase a diffraction limited acceptance angle of the apparatus.

Abstract: An apparatus for redirecting radiation including a polarization dependent reflector and an optical component able to transform the polarisation of radiation as it passes through the component. Radiation having a first polarisation component impinging upon the reflector from a source is reflected towards a scene area. Radiation not having this polarisation component passes through the reflector. The radiation having the first polarisation is then transmitted towards a scene via the optical component. As the radiation passes via the optical component, reflects back from the scene and passes again via the optical component, the polarisation is changed to state where it can now pass through the polarisation dependent reflector. The apparatus allows a scene to be illuminated as if the illuminator were positioned at the viewpoint of an imaging system, and so aids uniform illumination of the scene.

Abstract: An illumination source of predominantly non-directional and incoherent millimeter-wave radiation for illuminating an area for passive millimeter-wave imaging comprises a container with at least a partly reflective internal surface and a plurality of exit apertures and a primary source of millimetre-wave radiation for emitting millimetre-wave radiation into the container. The primary source and the container are arranged so that a proportion of the millimetre-wave radiation emitted by the source undergoes reflection within the container before being emitted through the aperatures, such that the different paths lengths are at least equal to the coherence length of the radiation. This is facilitated if the bandwidth of the radiation is preferably at least 1 GHz. The container may be a box in which a waveguide is used to couple radiation from the primary source into the box. Alternatively, the container may be formed from a mesh and the plurality of holes is provided by the holes in the mesh.

Abstract: A method to inhibit translation of an mRNA, which is intitiated at an internal ribosome entry site of the mRNA and requires binding of a protein factor to that site, is disclosed. The method comprises a step of providing, in an in vitro, or in vivo system that is capable of translating the mNRA, an inhibitory effective amount of a molecule that selectively binds to the protein factor, thereby preventing that factor from binding to the mNRA. The inhibitor molecule is an RNA oligonucleotide consisting of less than 35 nucleotides or a structural mimic of such an RNA oligonucleotide.