Abstract: The present disclosure is directed toward drug coated balloons, and in particular to drug coated balloons having a drug coating layer that primarily uses therapeutic agents alone for improving the quality of treatments in which drug coated balloons are utilized. Particular aspects may be directed to drug coated balloon having an outer surface, and a drug coating layer on the outer surface of the balloon. The drug coating layer includes at least one therapeutic agent and is substantially free of excipients.

Abstract: The present disclosure relates generally to implementing biometric authentication, including providing user interfaces for: while the electronic device is in a first state in which a respective function of the electronic device is disabled, detecting one or more activations of the button; and in response to detecting the one or more activations of the button: capturing, with the one or more biometric sensors that are separate from the button, biometric data; if the biometric data satisfies biometric authentication criteria, transitioning the electronic device to a second state in which the respective function of the electronic device is enabled; and if the biometric data does not satisfy the biometric authentication criteria, maintaining the electronic device in the first state and displaying, on the display, an indication that biometric authentication has failed.

Abstract: The present invention relates to recombinant laminin adeno-associated viral vector (AAV) constructs and related methods for restoring laminin expression in deficient mammals, or in mammals with basement membrane instability.

Abstract: The present disclosure generally relates to techniques for managing contextual transactions. In some examples, at a sender electronic device, a first user provides authorization to purchase an item for a second user. In some examples, at a recipient device, the second user selects one or more attributes for the item and requests to claim the item. In some examples, an electronic device displays a representation of an item and a purchase affordance for purchasing the item using a payment system that is available on the electronic device.

Abstract: A vehicle system includes a controller that is configured to (a) store a plurality of passenger profiles regarding passengers of a vehicle where each of the plurality of passenger profiles include pre-stored characteristics of a respective passenger associated therewith, (b) acquire passenger identifying data regarding a present passenger in the vehicle, (c) identify a respective passenger profile associated with the present passenger from the plurality of passenger profiles based on the passenger identifying data, and (d) control a speaker positioned within the vehicle based at least in part on the respective passenger profile to emit noise-canceling sound waves to generate a noise suppression zone to suppress sound waves perceived by the present passenger.

Abstract: Disclosed herein are systems and methods for localization of a disease state (e.g., tissue of origin of cancer) using nucleic acid samples. In an embodiment, a method comprises receiving a plurality of cancer signals of a sample, each cancer signal indicating a probability that the sample is associated with a different disease state of a plurality of disease states. The method determines a first cancer signal having a greatest probability among the plurality of cancer signals. In accordance with a determination that the first cancer signal satisfies a criterion, the method associates the sample with a first disease state. In accordance with a determination that the first cancer signal does not satisfy the criterion, the method determines a second cancer signal having a second greatest probability among the plurality of cancer signals, and associates the sample with the first disease state and a second disease state.

Abstract: Computer-implemented methods and systems define hardware constraints for quantum processors such that the time required to estimate the energy expectation value of a given fermionic Hamiltonian using the method of Bayesian Optimized Operator Expectation Algorithm (BOOEA) is minimized.

Abstract: A hybrid quantum classical (HQC) computer, which includes both a classical computer component and a quantum computer component, implements improvements to the quantum approximate optimization algorithm (QAOA) which enable QAOA to be applied to valuable problem instances (e.g., those including several thousand or more qubits) using near-term quantum computers.

Abstract: Provided herein are methods of obtaining induced pluripotent stem cells from cells of a hematopoietic lineage.

Abstract: The present disclosure relates generally to antibodies and Fc fusion proteins comprising Fc variants, and uses thereof. The Fc variants disclosed herein exhibit elevated affinity towards FcRn at pH 6.0, and/or rapidly disassociate from FcRn at pH 7.

Abstract: Inventive embodiments are directed to components, subassemblies, systems, and/or methods for continuously variable transmissions (CVT). In one embodiment, a main axle is adapted to receive a shift rod that cooperates with a shift rod nut to actuate a ratio change in a CVT. In another embodiment, an axial force generating mechanism can include a torsion spring, a traction ring adapted to receive the torsion spring, and a roller cage retainer configured to cooperate with the traction ring to house the torsion spring. Various inventive idler-and-shift-cam assemblies can be used to facilitate shifting the ratio of a CVT. Embodiments of a hub shell and a hub cover are adapted to house components of a CVT and, in some embodiments, to cooperate with other components of the CVT to support operation and/or functionality of the CVT. Among other things, shift control interfaces and braking features for a CVT are disclosed.

Abstract: A method for maintaining a penetration rate of a drilling operation, where the drilling operation is carried out by a drilling rig having a hammer drill apparatus. A reference penetration rate for the hammer drill bit is chosen. A starting depth of cut is computed from the reference penetration rate, the measured hammer frequency, and the drill bit parameters. The system measures the actual penetration rate of the drill bit and computes an actual depth of cut. From the actual depth of cut a target bit rotation speed is computed. The target rotation speed is compared to the actual rotation speed, and the rotation speed is adjusted up or down to set the bit rotation speed at a value that will maintain the target rotation speed, notwithstanding changes in hammer frequency or ground conditions.

Abstract: An evaporative emission control canister system comprises an initial adsorbent volume having an effective incremental adsorption capacity at 25° C. of greater than 35 grams n-butane/L between vapor concentration of 5 vol % and 50 vol % n-butane, and at least one subsequent adsorbent volume having an effective incremental adsorption capacity at 25° C. of less than 35 grams n-butane/L between vapor concentration of 5 vol % and 50 vol % n-butane, an effective butane working capacity (BWC) of less than 3 g/dL, and a g-total BWC of between 2 grams and 6 grams. The evaporative emission control canister system has a two-day diurnal breathing loss (DBL) emissions of no more than 20 mg at no more than 210 liters of purge applied after the 40 g/hr butane loading step.

Abstract: An apparatus for closing a surgical incision comprises left and right base panels, a plurality of closure components, and a plurality of left and right axial supports coupled to the respective base panels. The closure components couple the left and right base panels to each other laterally and have left and right ends coupled to the respective base panels. The closure components are positioned laterally across the left and right panels, the left axial supports are disposed between pairs of left closure component ends, the right axial supports are disposed between pairs of right closure component ends, and the left and right axial supports are offset from one another such that a serpentine arrangement of consecutive closure components and axial supports is formed. The apparatus can be made of antimicrobial materials or materials impregnated with antimicrobial agents. A flexible adhesive cover can be provided over the apparatus when in use.

Abstract: A display film includes a transparent polymeric substrate layer having a 0.2% offset yield stress greater than 110 MPa and a transparent aliphatic cross-linked polyurethane layer having a thickness of 100 micrometers or less disposed on the transparent polymeric substrate layer. The transparent aliphatic cross-linked polyurethane layer has a glass transition temperature in a range from 11 to 27 degrees Celsius and a Tan Delta peak value in a range from 0.5 to 2.5. The display film has a haze value of 2% or less.

Abstract: Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.

Abstract: A method and system are provided for estimating ground state and excited state energies of fermionic Hamiltonians using a classically-boosted Variational Quantum Eigensolver (VQE). The disclosed technology overcomes the drawbacks of prior VQE methods, which require large numbers of circuit repetitions and excessive runtimes to achieve precision, especially when implemented using Noisy Intermediate-Scale Quantum NISQ) devices. The disclosed classically-boosted VQE provides an estimation of expectation values using classical methods. The quantum computer is not used to prepare the trial state, but instead uses the difference between the trial state and a classical tractable approximation to the target state. Ground-state energy estimations are provided at an accelerated rate. Also, the measurement reduction of single basis state boosting of conventional VQE, may be estimated using only the overlap between the ground state and the computational basis state used for boosting.