Patents by Inventor Peter D. Caravan

Peter D. Caravan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Activatable fibrin-binding probes
    Patent number: 10471163
    Abstract: Provided herein are methods for determining the presence or absence of active thrombus formation using a linear polypeptide that binds fibrin upon cyclization. Also provided are compounds comprising linear polypeptide probes that are cyclized in the presence of protein disulfide isomerase.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: November 12, 2019
    Assignee: The General Hospital Corporation
    Inventors: Galen Loving, Peter D. Caravan
  • Collagen imaging compositions
    Patent number: 10301358
    Abstract: Compounds and methods for imaging and/or assessing collagen are described. The compounds can include collagen binding peptides.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: May 28, 2019
    Assignee: Collagen Medical, LLC
    Inventors: Richard J. Looby, Peter D. Caravan, Thomas J. McMurry
  • COLLAGEN IMAGING COMPOSTIONS
    Publication number: 20180185520
    Abstract: Compounds and methods for imaging and/or assessing collagen are described. The compounds can include collagen binding peptides.
    Type: Application
    Filed: June 29, 2016
    Publication date: July 5, 2018
    Inventors: Richard J. Looby, Peter D. Caravan
  • Multimodal imaging of fibrin
    Patent number: 9889213
    Abstract: Fibrin-specific imaging agents that contain at least two imaging reporters are described, as well as methods of making and using the contrast agents.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: February 13, 2018
    Assignee: The General Hospital Corporation
    Inventor: Peter D. Caravan
  • COLLAGEN IMAGING COMPOSTIONS
    Publication number: 20160376319
    Abstract: Compounds and methods for imaging and/or assessing collagen are described. The compounds can include collagen binding peptides.
    Type: Application
    Filed: June 29, 2016
    Publication date: December 29, 2016
    Inventors: Richard J. Looby, Peter D. Caravan, Thomas J. McMurry
  • Collagen Imaging Compositions
    Publication number: 20160375155
    Abstract: Compounds and methods for imaging and/or assessing collagen are described. The compounds can include collagen binding peptides.
    Type: Application
    Filed: June 29, 2015
    Publication date: December 29, 2016
    Inventors: Richard L. Looby, Peter D. Caravan
  • Activatable fibrin-binding probes
    Publication number: 20160346411
    Abstract: Provided herein are methods for determining the presence or absence of active thrombus formation using a linear polypeptide that binds fibrin upon cyclization. Also provided are compounds comprising linear polypeptide probes that are cyclized in the presence of protein disulfide isomerase.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 1, 2016
    Inventors: Galen Loving, Peter D. Caravan
  • Multimodal Imaging of Fibrin
    Publication number: 20160199519
    Abstract: Fibrin-specific imaging agents that contain at least two imaging reporters are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: November 30, 2015
    Publication date: July 14, 2016
    Inventor: Peter D. Caravan
  • Methods for collagen imaging
    Patent number: 9386938
    Abstract: Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: July 12, 2016
    Assignee: Collagen Medical, LLC
    Inventors: Peter D. Caravan, Andrew Kolodziej, Zhaoda Zhang, Stephane Dumas, Biplab Kumar Das, Vincent Jacques, Richard Looby, Steffi K. Koerner, Wei-Chuan Sun, David R. Buckler, Aida Abujoub, Aaron K. Sato
  • Methods for Collagen Imaging
    Publication number: 20120114557
    Abstract: Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
    Type: Application
    Filed: September 12, 2011
    Publication date: May 10, 2012
    Applicant: COLLAGEN MEDICAL, LLC
    Inventors: Peter D. Caravan, Andrew Kolodziej, Zhaoda Zhang, Stephane Dumas, Biplab Kumar Das, Vincent Jacques, Richard Looby, Steffi K. Koerner, Wei-Chuan Sun, David R. Buckler, Aida Abujoub, Aaron K. Sato
  • Optically pure and enriched isomers of chelating ligands and contrast agents
    Patent number: 8048906
    Abstract: Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described, including methods for preparing optically-enriched or optically-pure compositions of the same.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 1, 2011
    Assignee: Catalyst Medical
    Inventors: John C. Amedio, Peter D. Caravan, Vincent Jacques, Kevin L. Zhou, Stuart Levy, Shirley Kalogeropoulos, Matthew Greenfield
  • Methods of collagen imaging
    Patent number: 8034898
    Abstract: Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: October 11, 2011
    Assignee: Collagen Medical, LLC
    Inventors: Peter D. Caravan, Andrew Kolodziej, Zhaoda Zhang, Stephane Dumas, Biplab Kumar Das, Vincent Jacques, Richard Looby, Steffi K. Koerner, Wei-Chuan Sun, David R. Buckler, Aida Abujoub, Aaron K. Sato
  • Peptide-based multimeric targeted contrast agents
    Patent number: 7927581
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: April 19, 2011
    Assignee: Factor 1A, LLC
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Systems and methods for targeted magnetic resonance imaging of the vascular system
    Patent number: 7412279
    Abstract: This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Methods and systems of the invention allow for improved anatomical information to be obtained from MRI images and allow the clinician to develop more effective treatment plans. In one aspect, the invention provides a method of determining the presence or absence of a stationary target within the vascular system of a mammal wherein two MRI data sets representing images of the vascular system and the stationary target are acquired after administration of a targeted MRI contrast agent. In another embodiment, both a targeted MRI contrast agent and a vascular MRI contrast agent are administered to a mammal, and both a vascular MRI and a targeted MRI data set are acquired.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: August 12, 2008
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Robert M. Weisskoff, Peter D. Caravan, Sonia Witte, Randall B. Lauffer, Alan P. Carpenter, Jr.
  • Peptide-based multimeric targeted contrast agents
    Patent number: 7238341
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: July 3, 2007
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Targeting multimeric imaging agents through multilocus binding
    Publication number: 20040005274
    Abstract: The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites.
    Type: Application
    Filed: May 27, 2003
    Publication date: January 8, 2004
    Applicant: Epix Medical, Inc., a Delaware corporation
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephane Dumas, Andrew Kolodziej, John C. Amedio, Peter D. Caravan, Zhaoda Zhang, Shrikumar Nair, Robert M. Weisskoff
  • Peptide-based multimeric targeted contrast agents
    Publication number: 20030180222
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: July 30, 2002
    Publication date: September 25, 2003
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Systems and methods for targeted magnetic resonance imaging of the vascular system
    Publication number: 20030028101
    Abstract: This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Methods and systems of the invention allow for improved anatomical information to be obtained from MRI images and allow the clinician to develop more effective treatment plans. In one aspect, the invention provides a method of determining the presence or absence of a stationary target within the vascular system of a mammal wherein two MRI data sets representing images of the vascular system and the stationary target are acquired after administration of a targeted MRI contrast agent. In another embodiment, both a targeted MRI contrast agent and a vascular MRI contrast agent are administered to a mammal, and both a vascular MRI and a targeted MRI data set are acquired.
    Type: Application
    Filed: July 30, 2002
    Publication date: February 6, 2003
    Inventors: Robert M. Weisskoff, Peter D. Caravan, Sonia Witte, Randall B. Lauffer, Alan P. Carpenter