Abstract: A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, the at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.

Abstract: The present disclosure relates to a metered dose dispensing valve for dispensing metered volumes of an aerosol formulation from an aerosol container. The valves described herein are particularly suitable for use with metered dose inhalers for the oral delivery of medicaments. By combining the compliant biasing member and the second valve body into an integral single component it is possible to provide a desirable metered dose dispensing valve for use in inhalation devices or for use in the provision of canisters targeted for use in inhalation devices.

Abstract: A method for filling a plurality of microdepressions in a major surface of a web with finely divided powder in which the web is fed continuously to and through a powder filling stage including a driven roller. At the powder filling stage, the powder, which is fed either onto the web upstream of the roller or to the roller of the powder filling stage, is filled into the microdepressions of the web using the driven roller, wherein said roller is rotating about an axis generally transverse to the direction of web, while the surface speed of the roller and the web speed are different and wherein the roller and web are positioned relative to one another, such that between the upper surface of the web and the outer surface of the roller there is a gap.

Abstract: Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder.

Abstract: An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gask

Abstract: A dose counter for use in connection with a device adapted for metered dispensing of a medication is described. The dose counter has a first count indicator that has a first indicia bearing surface, with the first count indicator being rotatable about a first axis. The dose counter also has a second count indicator that has a second indicia bearing surface, with the second count indicator being rotatable about a second axis. The second axis is disposed at an obtuse angle with respect to the first axis, and the first and second indicia bearing surfaces align at a common viewing area to collectively present at least a portion of a medication dosage count.

Abstract: This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction.

Abstract: A dose counter for use in connection with a device adapted for metered dispensing of a medication is described. The dose counter has a first count indicator that has a first indicia bearing surface, with the first count indicator being rotatable about a first axis. The dose counter also has a second count indicator that has a second indicia bearing surface, with the second count indicator being rotatable about a second axis. The second axis is disposed at an obtuse angle with respect to the first axis, and the first and second indicia bearing surfaces align at a common viewing area to collectively present at least a portion of a medication dosage count.

Abstract: The present disclosure provides dry powder inhalers, containers for carrying a dose of dry powder medicament particles for dry powder inhalers, and a hinge that, while enjoying broader applicability, may be used in such inhalers.

Abstract: Dry powder inhaler dose counters capable of making a display move swiftly between digits, in contrast to the progressive movement that occurs in simple gearing mechanisms.

Abstract: Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.

Abstract: An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gask

Abstract: Use of metal powder injection molding for the manufacture of a metal valve component, such as a valve stem or a valve body, of a metered dose dispensing valve for use in a medicinal pressurized metered dose dispenser, such as an inhaler.

Abstract: A method for filling a plurality of microdepressions in a major surface of a web with finely divided powder in which the web is fed continuously to and through a powder filling stage including a driven roller. At the powder filling stage, the powder, which is fed either onto the web upstream of the roller or to the roller of the powder filling stage, is filled into the microdepressions of the web using the driven roller, wherein said roller is rotating about an axis generally transverse to the direction of web, while the surface speed of the roller and the web speed are different and wherein the roller and web are positioned relative to one another, such that between the upper surface of the web and the outer surface of the roller there is a gap.

Abstract: A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, said valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, said at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.

Abstract: The present invention relates to a novel design for a metering valve that provides improved consistency of formulation delivery. Generally, the metering valve includes (a) a valve stem that generally defines a longitudinal axis and includes a body portion having a metering surface, wherein the longitudinal axis and a plane tangential to at least a portion of the metering surface define an angle from about 2° to about 90°; and (b) a valve body having an internal chamber defined at least in part by the body wall and includes a metering portion configured to substantially conform to the metering surface of the valve stem.

Abstract: This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction.

Abstract: This application discloses a dose counter for use in connection with a device adapted for metered dispensing of a medication. The dose counter has a first count indicator that has a first indicia bearing surface, with the first count indicator being rotatable about a first axis. The dose counter also has a second count indicator that has a second indicia bearing surface, with the second count indicator being rotatable about a second axis. The second axis is disposed at an obtuse angle with respect to the first axis, and the first and second indicia bearing surfaces align at a common viewing area to collectively present at least a portion of a medication dosage count.

Abstract: An adaptor for use with a container equipped with a dispensing valve that comprises a valve stem movable between an inner closed or priming position and an outer dispensing position, for dispensing doses of pressurized aerosol formulation as well as dispensers comprising such an adaptor and container; said adaptor being adapted to receive the container and comprising an actuation mechanism, said actuation mechanism being arranged such that the user will operate the mechanism by applying a depressive or squeezing force and the dose will be dispensed upon said depressive or squeezing force and said actuation mechanism being arranged such that upon release of the mechanism by the user, the valve stem of the dispensing valve will be moved automatically into its inner closed or priming position.

Abstract: A metal component, in particular a metal component of a medicinal device, such as a pharmaceutical aerosol delivery device, having a through hole extending along an axis from a first surface (10) to a second surface (20) of said component and having a sidewall, wherein the sidewall (30) in its planar cross-section along said axis through the first and second surfaces (10) has a geometric form generally corresponding to an arc of a segment (16) of a circle, an oval or an ellipse where the end points (11, 12) of the chord (17) of said segment (16) are located at the points of intersection of the sidewall (30) with the first and second surfaces (10, 20) (a “rounded sidewall”).