Patents by Inventor Peter D. J. Grootenhuis

Peter D. J. Grootenhuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20080306062
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: May 5, 2008
    Publication date: December 11, 2008
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D.J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • Modulators of muscarinic receptors
    Patent number: 7446112
    Abstract: The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: November 4, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Peter D. J. Grootenhuis, Miguel Garcia-Guzman Blanco, Lewis R. Makings, Philip Martin Londo
  • Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters
    Patent number: 7407976
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: August 5, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark T. Miller, Sarah S. Hadida Ruah, Peter D. J. Grootenhuis, Matthew Hamilton
  • Modulators of ATP-binding cassette transporters
    Publication number: 20080113985
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: November 8, 2006
    Publication date: May 15, 2008
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D.J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
    Patent number: 7297708
    Abstract: Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological disorders, e.g., anxiety and depression, treatable by antagonizing CRF receptors.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: November 20, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Andreas Termin, Peter D. J. Grootenhuis, Dean M. Wilson, Valentina Molteni, Long Mao, Angelo Castellino, Zhicai Yang, Anthony Pechulis, Mark Suto
  • Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
    Publication number: 20030229091
    Abstract: Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): 1
    Type: Application
    Filed: September 5, 2002
    Publication date: December 11, 2003
    Inventors: Andreas Termin, Peter D.J. Grootenhuis, Dean M. Wilson, Valentina Molteni, Long Mao, Angelo Castellino, Zhicai Yang, Anthony Pechulis, Mark Suto
  • Bisconjugates comprising two saccharides and a spacer
    Patent number: 5705489
    Abstract: The invention relates to a tuneable bisconjugate comprising two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one unit being uronic acid, characterized in that at least one of the saccharides per se has anti-thrombotic activity, and that the spacer connects at least one saccharide to the other through its non-reducing end, the chain length of the spacer being 20-120 atoms.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: January 6, 1998
    Assignees: Akzo Nobel N.V., Elf Sanofi
    Inventors: Constant A. A. Van Boeckel, Peter D. J. Grootenhuis, Maurice Petitou, Pieter Westerduin