Patents by Inventor Peter D. J. Osman

Peter D. J. Osman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Receptor membranes and ionophore gating
    Patent number: 5874316
    Abstract: The present invention provides a membrane the conductivity of which is dependent on the presence or absence of an analyte. The membrane comprises a closely packed array of self-assembling amphiphilic molecules and two ionophore components. A receptor molecule reactive with the analyte is provided on one of the ionophore components. The binding of the analyte to the receptor molecule causes a change in the relationship between the ionophore components such that the flow of ion across the membrane is prevented or allowed. The ionophore components are preferably selected from the group consisting of amphotericin B, gramicidin A monomers and combinations thereof, with gramicidin A monomers being particularly preferred. The present invention also provides a membrane including receptors directed against the Fc region of antibodies. These receptors are preferably derived from polyclonal antibodies.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: February 23, 1999
    Assignee: Australian Membrane Biotechnology Research Institute
    Inventors: Bruce A. Cornell, Vijoleta L. B. Braach-Maksvytis, Ronald J. Pace, Lionel G. King, Burkhard Raguse, Peter D. J. Osman
  • Receptor membranes and ionophore gating
    Patent number: 5443955
    Abstract: The present invention provides a membrane the conductivity of which is dependent on the presence or absence of an analyte. The membrane comprises a closely packed array of self-assembling amphiphilic molecules and two ionophore components. A receptor molecule reactive with the analyte is provided on one of the ionophore components. The binding of the analyte to the receptor molecule causes a change in the relationship between the ionophore components such that the flow of ion across the membrane is prevented or allowed. The ionophore components are preferably selected from the group consisting of amphotericin B, gramicidin A monomers and combinations thereof, with gramicidin A monomers being particularly preferred. The present invention also provides a membrane including receptors directed against the Fc region of antibodies. These receptors are preferably derived from polyclonal antibodies.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: August 22, 1995
    Assignee: Australian Membrane and Biotechnology Research Institute
    Inventors: Bruce A. Cornell, Vijoleta L. B. Braach-Maksvytis, Ronald J. Pace, Lionel G. King, Burkhard Raguse, Claire R. Baxter, Ruth M. Hall, Carol A. Morris, Peter D. J. Osman
  • Sensitivity and selectivity of ion channel biosensor membranes
    Patent number: 5234566
    Abstract: The present invention provides a biosensor comprising at least one lipid membrane, each membrane including at least one gated ion channel. The membranes comprise a closely packed array of self-assembly amphophilic molecules and the gated ion channel has a conductance which is dependent upon an electric field applied across the membrane. The biosensor of the present invention may comprise a plurality of discrete membranes each including at least one gated ion channel. The conductance of each of the membranes is measurable independently of the conductance of the other membranes.
    Type: Grant
    Filed: April 18, 1991
    Date of Patent: August 10, 1993
    Assignee: Australian Membrane and Biotechnology Research Institute Ltd.
    Inventors: Peter D. J. Osman, Bruce A. Cornell, Burkhard Raguse, Lionel G. King