Abstract: Improved compositions and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an aqueous solution of GDF-5 and a biocompatible acid, such as hydrochloric, acetic, phosphoric, or trifluoroacetic acid, wherein the solution has a pH of from about 3.0 to about 3.6, thereby providing for improved stability of the GDF-5 protein during handling and prolonged storage at reduced temperatures.

Abstract: A system and method for tracking user security credentials in a distributed computing environment. The security credentials of an authenticated user includes not just his unique user identifier, but also a set of security attributes such as the time of authentication, the location where the user is authenticated (i.e., intranet user v. internet user), the authentication strength, and so on. The security attributes are used in access control decisions. The same user can be given different authorization if he has a different security attribute value. Security credentials may be generated either by WebSphere security code or by third party security provider code.

Abstract: Objects on application servers may be defined into classes which receive different levels of security protection, such as definition of user objects and administrative objects. Domain-wide security may be enforced on administrative objects, which user object security may be configured separately for each application server in a domain. In a CORBA architecture, IOR's for shared objects which are to be secured on a domain-wide basis, such as administrative objects, are provided with tagged components during IOR creation and exporting to a name server. Later, when the IOR is used by a client, the client invokes necessary security measures such as authentication, authorization and transport protection according to the tagged components.

Abstract: Objects on application servers may be defined into classes which receive different levels of security protection, such as definition of user objects and administrative objects. Domain-wide security may be enforced on administrative objects, which user object security may be configured separately for each application server in a domain. In a CORBA architecture, IOR's for shared objects which are to be secured on a domain-wide basis, such as administrative objects, are provided with tagged components during IOR creation and exporting to a name server. Later, when the IOR is used by a client, the client invokes necessary security measures such as authentication, authorization and transport protection according to the tagged components.

Abstract: A method and apparatus for preventing rogue implementations of a security-sensitive class interface are provided. With the method and apparatus, a unique identifier (UID) is created by a server process when the server process is started. Anytime the server process, i.e. a server runtime environment, instantiates a new credential object following start-up of the server process, the encrypted UID is placed into a private field within the new credential object. In addition, the UID is encrypted and stored in a private class of the server runtime environment. A verification class is provided within the server runtime environment which includes one or more methods that receive the credential object as a parameter and return true or false as to the validity of the credential object.

Abstract: A method and apparatus for preventing rogue implementations of a security-sensitive class interface are provided. With the method and apparatus, a unique identifier (UID) is created by a server process when the server process is started. Anytime the server process, i.e. a server runtime environment, instantiates a new credential object following start-up of the server process, the encrypted UID is placed into a private field within the new credential object. In addition, the UID is encrypted and stored in a private class of the server runtime environment. A verification class is provided within the server runtime environment which includes one or more methods that receive the credential object as a parameter and return true or false as to the validity of the credential object.

Abstract: There is disclosed an improved rooflight 100. A first aspect of the rooflight provides a perimeter lip 1401 which protects an edge of a pane 210 of glass from being accidentally chipped or cracked. A second aspect of the present invention provides a channel for a blind 1100, which channel is formed by two cooperating channel sections 1601, 1602. A third aspect of the present invention provides a flashing system 1700. Another aspect of the rooflight 100 provides a water deflector 450 for preventing rain water from impinging directly onto a weather seal between a casement 120 and baseplate 110. Another aspect provides removable linings 610, 620, 1210, 1220 which can be mounted an interior face of the casement 120 and/or baseplate 110. Another aspect provides a slot 1000, for securing flashing 800, 810, which extends around the perimeter of the baseplate 110.

Abstract: A method of automatic drilling of a well with coil tubing or drill pipe tubing utilizes AC motors coupled to variable frequency drives controlled by a programmable logic controller. For example, a coil tube injector is supported in a mast for injecting coil tube from a reel and into a wellbore for drilling the wellbore. The AC motors for the injector are driven for controlling a rate of injection of coil tube by the injector for maintaining at least one drilling parameter such as weight-on-bit, differential mud pressure or rate of penetration. The AC motor for the reel is also controlled for driving the reel and maintaining a relative rate of coil tube supplied from the reel to the injector. Drawworks and a top drive supported by the draworks can also be equipped with AC motors and variable frequency drives for controlling a drilling rate for maintaining at least one of the drilling parameters.

Abstract: A feed-forward flow controller is designed to calculate a target valve position from a target flow. Correction is made for liquid or gas pressure drop across the valve and for the valve flow modulating member geometry. This feed-forward action may also be used to linearize a feed-back flow control loop.

Abstract: The invention features a method of producing a high mannose glucocerebrosidase (hmGCB) which includes: providing a cell which is capable of expressing glucocerebrosidase (GCB), and allowing production of GCB having a precursor oligosaccharide under conditions which prevent the removal of at least one mannose residue distal to the pentasaccharide core of the precursor oligosaccharide of GCB, to thereby produce an hmGCB preparation. Preferably, the condition which prevents the removal of at least one mannose residue distal to the.pentasaccharide core is inhibition of a class 1 processing mannosidase and/or a class 2 processing mannosidase. The invention also features an hmGCB preparation and methods of using an hmGCB preparation.

Abstract: A feed-forward flow controller is designed to calculate a target valve position from a target flow. Correction is made for liquid or gas pressure drop across the valve and for the valve flow modulating member geometry. This feed-forward action may also be used to linearize a feed-back flow control loop.

Abstract: The present invention provides a pumped helium circuit comprising a compressor (14) with a high pressure port (16) and a low pressure port (18) each connected to a supplied equipment (61,63,65,67) to respectively supply compressed helium to, and receive compressed helium from, the supplied equipment; a pressure relief valve (12) operable to link the high pressure port to the low pressure port in response to a predetermined pressure differential; a non-return valve (13) located between a low pressure side of the pressure relief valve and the supplied equipment; and means for preventing oil carry-over from the compressor to the supplied equipment.

Abstract: The present invention relates to an isolated small RNA virus capable of infecting insect species including Heliothis species, and to the nucleotide sequences and proteins encoded thereby. The invention contemplates uses of the virus in controlling insect attack in plants.

Abstract: Methods and apparatus are provided for interactively building flight paths for entry into an aircraft flight management system (FMS). The apparatus comprises a database containing map information, a display for presenting the map information, a user controlled cursor and selection buttons, all under the control of a graphics processor. The processor presents the map information with included navigation features on the display, correlated with the aircraft position and cursor location. When the cursor overlies a navigational feature (airways, waypoints, etc.), the processor highlights the feature. Feature ID information may also pop up when the feature is highlighted. Using a mouse button or equivalent, the user selects the highlighted feature or ID, whereupon the processor sends the information associated therewith to the FMS. By successively highlighting and selecting features or IDs an entire flight path can be identified and entered automatically into the FMS without the need for individual text entry.

Abstract: The invention relates to a novel approach for the diagnosis and therapy of renal cell carcinoma, and other renal tumors, for example Wilms' tumor or other tumors not originating from the kidney or non-malignant kidney pathologies. The areas of application of the invention include the field of medicine and the pharmaceutical industry but also basic biology. The aim of the invention is to provide novel forms of treatment which are urgently required regarding the present state-of-the-art in treatment of renal carcinoma and other cancers. It was discovered that the Nbk protein which is highly expressed in normal renal tissue, is either not expressed at all or only weakly expressed in the tumor tissue. The protein expression and the loss of Nbk was examined in renal cell carcinoma samples by the use of immunohistochemistry, PCR strategies, mutation and deletion analyses.

Abstract: A method and apparatus for preventing rogue implementations of a security-sensitive class interface are provided. With the method and apparatus, a unique identifier (UID) is created by a server process when the server process is started. Anytime the server process, i.e. a server runtime environment, instantiates a new credential object following start-up of the server process, the encrypted UID is placed into a private field within the new credential object. In addition, the UID is encrypted and stored in a private class of the server runtime environment. A verification class is provided within the server runtime environment which includes one or more methods that receive the credential object as a parameter and return true or false as to the validity of the credential object.

Abstract: A tennis training simulation system is disclosed that improves both reaction time and ground stroke techniques within a limited physical training environment. This training system combines simulated service of a tennis ball from a service line over a virtual net, and delivery of real tennis ball to an awaiting tennis student. In the system of this invention, the tennis ball delivery system includes an automatic tennis ball machine equipped with an array of lights or LED's that simulate the service of a tennis ball from a service line, a simulated trajectory of the tennis ball over a virtual net, and a simulated first bounce of a tennis ball coupled immediately thereafter with real in-flight delivery of an actual tennis ball to an awaiting tennis student.