Patents by Inventor Peter Danilo, Jr.

Peter Danilo, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160333071
    Abstract: It is demonstrated that hyperpolarization-activated cyclic nucleotide-gated (HCN)-based biological pacing, especially that achieved by transduction of the HCN2 gene into cardiac cells in vivo, was significantly improved by co-transduction of the skeletal muscle sodium channel 1 (SkMI) gene. Expression of both genes hyperpolarized the action potential (AP) threshold. When viral biological pacemaker constructs carrying genes for HCN2 and SkMI were injected into the heart of dogs in vivo, the pacemaker function was facilitated by the slow depolarizing HCN2 current and the hyperpolarized AP threshold generated by SkMI. This dual gene therapy provided both highly efficient pacing and a brisk autonomic response that is superior to those of previously developed gene- or cell-based approaches.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 17, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Michael R. Rosen, Gerard J. Boink, Hanno L Tan, Richard B. Robinson, Ira S. Cohen, Peter R. Brink, Peter Danilo, Jr.
  • Publication number: 20130110218
    Abstract: This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
    Type: Application
    Filed: June 27, 2012
    Publication date: May 2, 2013
    Applicants: The Research Foundation of State University of New York, The Trustees of Columbia University in the City of New York
    Inventors: Michael R. Rosen, Peter R. Brink, Ira S. Cohen, Richard B. Robinson, Peter Danilo, JR.
  • Patent number: 8236296
    Abstract: This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: August 7, 2012
    Assignees: The Trustees of Columbia University in the City of New York, The Research Foundation of State University of New York
    Inventors: Michael R Rosen, Peter R. Brink, Ira S. Cohen, Richard B Robinson, Peter Danilo, Jr.
  • Publication number: 20110223144
    Abstract: A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
    Type: Application
    Filed: May 17, 2011
    Publication date: September 15, 2011
    Applicants: The Trustees Of Columbia University In The City Of New York, The Research Foundation of State University of New York
    Inventors: Peter R. Brink, Ira S. Cohen, Michael R. Rosen, Richard B. Robinson, Peter Danilo, JR.
  • Patent number: 7968126
    Abstract: A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: June 28, 2011
    Assignees: The Trustees of Columbia University in the City of New York, The Research Foundation of State University of New York
    Inventors: Peter R. Brink, Ira S. Cohen, Michael R Rosen, Richard B Robinson, Peter Danilo, Jr.
  • Publication number: 20100189701
    Abstract: The present invention provides compositions and methods of treatment for atrial fibrillation and ventricular tachycardia. The compositions are useful for modifying the conducting properties of heart tissues in which impulses are generating and/or are useful for altering refractoriness without prolonging repolarization.
    Type: Application
    Filed: December 26, 2007
    Publication date: July 29, 2010
    Inventors: Ira S Cohen, Peter R. Brink, Michael R. Rosen, Richard B. Robinson, Peter Danilo, JR., Heather S. Duffy