Abstract: Systems and methods for encrypting and decrypting data during an active data communication are disclosed. In one embodiment, seed data is received. A number of first seed bits are extracted from the seed data. The extracted first seed bits is used to index into a first index location of first one-time pad (OTP) data and obtain system setup random data from the first OTP data. System configuration information including a number of cipher parameters is defined based on the system setup random data, where the number of cipher parameters includes encryption cipher parameters and decryption cipher parameters. The data is encrypted or decrypted based, respectively, at least on the encryption cipher parameters or the decryption cipher parameters to generate encrypted data or decrypted data respectively.