Abstract: Polycarbonate is prepared by reactive extrusion on a reactive extruder. A method incorporates the steps of introducing a polycarbonate oligomer, an activated carbonate residue, and a transesterification catalyst to the extruder through a feed section. The extruder has the feed section, a polycarbonate exit section, and a reaction section between the feed section and the polycarbonate exit section. The reaction section is made up of at least one conveying section, kneading sections, and venting sections. The configuration of the reaction section requires that at least one venting section be disposed between each pair of kneading sections, and that the kneading sections and venting sections are selected such that the number of venting sections minus the number of kneading sections is greater than or equal to one. The method further contains the step of extruding the reaction components at a temperature in a range between 100° C. and 500° C.

Abstract: Polycarbonate is prepared by reactive extrusion on a reactive extruder. A method incorporates the steps of introducing a polycarbonate oligomer, an activated carbonate, and a transesterification catalyst to the extruder through a feed section. The extruder has a feed section, a polycarbonate exit section, and a reaction section between the feed section and the polycarbonate exit section. The reaction section has one or more devolatilization units, wherein each devolatilization unit incorporates an array of vent-conveying sections and conveying sections arranged in a configuration of: (C V C)x(V)n, and/or (V C V)x(C)n. (V) is a vent-conveying section, (C) is a conveying section, x is 1 or more, and n is 1 or 0. The extruder screw in the vent-conveying sections and the conveying sections in each devolatilization unit have conveying elements or conveying elements and mixing elements and no elements that create a melt seal in the devolatilization unit.

Abstract: The present invention relates to a compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein: Ar is a substituted aryl or heteroaryl group bearing at least one nitro or azido group or is a group of formula (2) or (3) wherein R1, and R2, which may be the same or different are independently optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, aryl, COR3 or, together with the intervening carbon atom, form an optionally substituted heterocycloalkyl or carbocyclic ring; L is —OC(O)— or —OP(O)(OR6)—; n is 0 or 1; X is 0, S, NR7 or a single covalent bond; R3 is OR4 or NR4R5; R4, R5, R6 and R7 are each independently hydrogen or optionally substituted alkyl or, where Rr is NR4R5, R4 and R5 can be joined to form, together with the intervening nitrogen atom, a heterocycloalkyl ring; R8 is hydrogen, alkoxy or dialkylaminoalkyl; R9 is optionally substituted alkyl; Rio is hydrogen, alkyl, alkoxy or dialkylaminoalkyl; R11 and R12 are independently hydrogen, alky

Abstract: The present invention is a method and apparatus for use within a die feeder associated with a circuit board assembly machines and includes, among other aspects and features, a cavity to capture and maintain the position of the die within a vacuum gripper. The invention also includes the interaction of a pair of nozzles whereas one moves within the nozzle tip containing the die cavity and has the ability to compensate for any offset between the nozzles.

Abstract: A wheel assembly for a small-scale machine includes a pair of opposing, individually-driven wheels, associated motors and possibly one or more gear assemblies. The motors receive separate drive signals from a control electronics subsystem of the wheel assembly. The motors can be connected to the wheels via the gear assemblies. Because the wheels are separately driven, driving the two wheel assemblies at similar or different speeds drives the wheel assembly over straight or curved paths. An orientation assembly allows the orientation of the wheels to the machine to be controllably altered. A height adjusting assembly allows the distance between the wheels and a point on the machine where the wheel assembly is attached to be adjusted. The rotational axis that the wheel assembly rotates about when re-oriented need not pass through either wheel of the wheel assembly. The wheels can be driven by control signals generated by on-board control electronics.

Abstract: A thermal nonlinear cell and method. The cell includes a substantially planar nonlinear medium and a mechanism for removing thermal energy from the medium in a direction substantially orthogonal to said medium. In one embodiment, the mechanism for removing thermal energy is a thermally conductive window mounted adjacent to the medium. Preferably, the mechanism includes plural thermally conductive windows between which the nonlinear medium is disposed. In the best mode, the windows are sapphire and the nonlinear medium is a fluid. The windows and the medium are transmissive with respect to first and second beams that interfere with each other and create an interference pattern in the cell. The interference pattern is sampled by a sampling hologram created within the multiple layers of the medium. The interference pattern is used via a sampling hologram to create a phase conjugate of a signal beam. The windows move thermal energy from the medium in a direction transverse to the longitudinal axis of the medium.

Abstract: The invention concerns the use of a vascular damaging agent or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for administration in divided doses for use in the production of a vascular damaging effect in a warm-blooded animal such as a human. In particular the vascular damaging agent is ZD6126, or a pharmaceutically acceptable salt thereof. The invention also relates to methods of treatment using a vascular damaging agent in divided doses.

Abstract: The system for end-to-end content publishing using XML with an object dependency graph is based on the following two design principles: First, separation of content and style: Information stored in the content management system is independent on how it is going to be presented. The presentation style is encapsulated elsewhere and can be used to customize the look and feel based on the end-user preferences as well as the delivery methods and devices. Second, reusability of information content: By encapsulating common information in fragments and subfragments and making these fragments insertable in other fragments, thereby avoid scattering and duplication of information. This enables a user to restrict the edit operations to a limited number of relevant fragments, to affect global changes. In addition, the present invention provides data consistency and data integrity in the content management.

Abstract: Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis. Embodiments include a 5(6)-substituted benzimidazole-2-carbamate of formula I wherein A represents a multi-substituted alkyl group or aromatic ring.

Abstract: A compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein Ar is a substituted heteroaryl group bearing at least one nitro or azido group or is a group of formula (2) or (3); R1 is hydrogen, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R2 is alkyl, alkoxy, thialkoxy or halo; R3, R4 and R5 are each independently alkyl, alkoxy, thialkoxy or halo with the proviso that at least two of R3, R4 or R5 are alkoxy; L is —OC(O)— or —OP(O)(OR6)—; n is 0 or 1; X is O, S or NR7; Y is hydrogen, alkyl, alkoxy, thialkoxy, halo, hydroxy or dihydrogenphosphate; R6 is hydrogen or alkyl; R7 is hydrogen or alkyl; R8 is hydrogen, alkoxy or dialkylaminoalkyl; R9 is optionally substituted alkyl; R10 is hydrogen, alkyl, alkoxy or dialkylaminoalkyl; R11, and R12 are independently hydrogen, alkyl, alkoxy, thialkoxy, amono alkylamino, dialkylamino, morpholino, alkylmorpholino, piperidino, alkylpiperidiono, piperazino, alkylpiperazino or 1-aziridinyl; and A, togethe

Abstract: A retracting eye drape assembly is disclosed for use around a patient's eye to seclude and seal off the operative field during eye surgery. The drape assembly includes a retraction member connected to the drape and configured to engage the patient's eyelid, an extension member connected to the retraction member or to the drape and configured to substantially enclose the patient's eyelid, and a retraction flap configured to secure the patient's eyelid in a substantially retracted position. A method of applying an eye drape assembly is disclosed. After application of the drape to the patient's face, and while the patient's eyelid is closed, the patient's eyelid is engaged by a retraction member connected to the drape and retracted. While retracted, the patient's eyelid is substantially enclosed to seclude the eyelid and eyelashes from the operational area. The secluded eyelid and eyelashes are then secured in a retracted position.

Abstract: Compositions for the inhibition of the formation of new vasculature by angiogenesis are provided comprising the combination of a vasculature damaging agent and an inhibitor of the formation or action of nitric oxide in mammalian systems. There are also provided the use of said combinations in medicaments and kits of said compounds and treatment employing said materials.

Abstract: A medical diagnostic instrument includes a housing containing at least one battery and a light source, such as a lamp, for illuminating a medical target. A switch includes a movable member that selectively moves at least one of the battery and the lamp into and out of electrical connection with the other. The instrument is preferably fabricated from a diecast or an extrusion process wherein a thin plastic sleeve member having text and/or graphic materials can be shrink fitted onto an extruded handle.

Abstract: The invention relates to the use of compounds of formula (I): wherein X is —C(O)—, —C(S)—, —C?NOH, or —CH(R7)— wherein R7 is hydrogen, hydroxy, C1-7alkoxy, —OR8 or —NR8R9 (wherein R8 is a group —Y1R10 (wherein Y1 is a direct bond, —C(O)—, —C(S)—, —S—, —C(O)O—, —C(O)NR11—, —SO2— or —SO2NR12— (wherein R11 and R12, which may be the same or different, each independently represents hydrogen; C1-3alkyl or C1-3alkoxyC2-3alkyl) and R10 is as defined herein, R9 includes hydrogen; R11, R12 and R13 are as defined herein and are preferably methyl; R4, R5 and R6 are as defined herein with the proviso that R5 is not hydroxy, alkoxy, substituted alkoxy, —OPO3H2, —O—C1-7alkanoyl or benzyloxy; and salts thereof in the manufacture of a medicament for use in the production of a vascular damaging effect in warm-blooded animals such as humans.

Abstract: The present invention is a method and apparatus for use within a die feeder associated with a circuit board assembly machines and includes, among other aspects and features, a cavity to capture and maintain the position of the die within a vacuum gripper. The invention also includes the interaction of a pair of nozzles whereas one moves within the nozzle tip containing the die cavity and has the ability to compensate for any offset between the nozzles.

Abstract: The present invention is a method and apparatus conveying a roll of liner stock bearing removably adhered components such as labels. The liner is pulled through the feeder by a capstan drive having opposed fluted nip rollers driven by a stepper motor. Advance of the stepper motor is controlled by a programmable electronic controller. The linered labels are led through a tensioner and around an acute-angle peeler edge which separates the labels from the liner. The peeling action advances a label onto a platform comprising a bed of rollers having an inherently low-adherence surface. Preferably the rollers are undercut to form circumferential ridges and reduce the surface area in contact with the label adhesive and to minimize adherence thereto. When peeling of a label is completed, the label has been advanced onto the roller bed to precisely the proper location for acquisition by a pick-and-place machine.

Abstract: The present invention is a method and apparatus conveying a roll of liner stock bearing removably adhered components such as labels. The liner is pulled through the feeder by a capstan drive having opposed fluted nip rollers driven by a stepper motor. Advance of the stepper motor is controlled by a programmable electronic controller. The linered labels are led through a tensioner and around an acute-angle peeler edge which separates the labels from the liner. The peeling action advances a label onto a platform comprising a bed of rollers having an inherently low-adherence surface. Preferably the rollers are undercut to form circumferential ridges and reduce the surface area in contact with the label adhesive and to minimize adherence thereto. When peeling of a label is completed, the label has been advanced onto the roller bed to precisely the proper location for acquisition by a pick-and-place machine.

Abstract: The invention relates to a method for the production of a vascular damaging effect in a warm-blooded animal such as a human, which comprises administering to said animal an effective amount of ZD6126 or a pharmaceutically NHCOCH acceptable salt thereof, before, after or simultaneously with an effective amount of one of the following therapies: i) ionising radiation; ii) a platinum anti-tumour agent; and iii) a taxane. The invention also relates to the use of ZD6126 and one of the above therapies in the manufacture of a medicament for use in the production of a vascular damaging effect in a warm-blooded animal such as a human and to pharmaceutical compositions and kits each comprising ZD6126 and one of a platinum anti-tumour agent and a taxane.

Abstract: Methods for promoting savings through a computer-enabled certificate program are provided. An exemplary method comprises the steps of: purchasing a certificate; issuing the certificate, wherein the certificate is transmitted to a recipient; redeeming the certificate for a monetary value; and directing the monetary value to a savings vehicle, wherein the savings vehicle is selected by the recipient. Systems are also provided.

Abstract: In recapitulation, the present invention is a method and apparatus for the reliable removal and installation of a component feeding system, such as a direct die feeder, within a printed circuit board or similar assembly machine such as those used in the assembly of printed circuit boards. The invention employs a docking channel operatively affixed to the assembly machine, where the docking channel includes at least a pair of parallel grooves into which alignment rails on the component feeder may be inserted. In this way, the position of the component feeder may be controlled. The docking channel may further include stops, safety locks, alignment pins and a transport device to facilitate easy removal and exchange of component feeders on an assembly machine.