Abstract: An apparatus for perfusing an organ or tissue including a perfusion circuit for perfusing the organ or tissue with liquid perfusate; and an oxygenation system for oxygenating perfusate that recirculates through the perfusion circuit. The oxygenation system includes an oxygen circuit for delivering oxygen to the liquid perfusate and an air circuit for delivering ambient air to the liquid perfusate. The air may be pumped through the oxygenation system via an air pump. The air or oxygen may be bubble through the perfusate to increase oxygen levels in the perfusate. Such supplemental oxygen may beneficial during hypothermic preservation of organs.

Abstract: An apparatus for perfusing an organ or tissue includes a perfusion circuit for perfusing the organ or tissue; a controller configured to control the apparatus; and a detector configured to detect an optional component of the apparatus, and provide a signal to the controller indicative of the presence of the optional component, wherein the controller is configured to control the perfusion circuit in a first mode when the optional component is detected and to control the perfusion circuit in a second mode when the optional component is not detected.

Abstract: An organ perfusion apparatus may include at least two tubes connected to an organ or tissue. A method of perfusing an organ or tissue may include connecting a first end of each of the at least two tubes to an organ or tissue, applying a fluid motive force to a perfusion fluid in the two tubes to force the fluid through the two tubes into the organ or tissue, and perfusing the organ or tissue through the at least two tubes such that the fluid motive force, provided by, e.g., a pump, and backpressure generated by the organ or tissue, establishes a flow balance between the at least two tubes. The flow balance may be altered without altering the fluid motive force that is applied.

Abstract: A bag includes an organ transporter compartment to contain an organ transporter disposed in the transporter compartment. The bag may include openings to access portions of the organ transporter, such as a battery or power cable, when the organ transporter is disposed in the bag. The bag may also include a frame and handles. The handles may include structure adapted to mate with handles on the organ transporter. The bag may also include a single cover that provides access to multiple compartments with their own internal covers. Also, the bag may include windows to view documents stored in the bag and/or to view and/or display control panels on the organ transporter.

Abstract: An apparatus for perfusing an organ or tissue including a perfusion circuit for perfusing the organ or tissue with liquid perfusate; and an oxygenation system for oxygenating perfusate that recirculates through the perfusion circuit. The oxygenation system includes an oxygen circuit for delivering oxygen to the liquid perfusate and an air circuit for delivering ambient air to the liquid perfusate. The air may be pumped through the oxygenation system via an air pump. The air or oxygen may be bubble through the perfusate to increase oxygen levels in the perfusate. Such supplemental oxygen may beneficial during hypothermic preservation of organs.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a coolant container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: A perfusion apparatus includes a coolant container having a basin-receiving recess that is at least partly surrounded by an inner chamber; a basin that is shaped to fit within the basin-receiving recess of the coolant container; and a cradle that is shaped to accept an organ and fit within the basin. The basin-receiving recess of the coolant container, the basin and the cradle each have positioning elements that are oriented such that the cradle is keyed to fit within the basin and the basin is keyed to fit within the coolant container, each in a single predetermined orientation. The plurality of positioning elements on the basin may include a plurality of protrusions on an outer surface of the basin.

Abstract: A perfusion apparatus including a perfusion circuit that perfuses an organ or tissue has a compartment that supports an organ or tissue during perfusion, an internal cover, and an external cover that closes the apparatus. A wall portion may extend substantially perpendicularly between the internal cover and the external cover to define a document compartment between the internal cover, the external cover and the wall portion. A tamper evident seal will not permit the external cover to open without creating a record of whether the external cover has been opened after the tamper evident seal has been activated.

Abstract: A perfusion apparatus includes a coolant container having a basin-receiving recess that is at least partly surrounded by an inner chamber; a basin that is shaped to fit within the basin-receiving recess of the coolant container; and a cradle that is shaped to accept an organ and fit within the basin. The basin-receiving recess of the coolant container, the basin and the cradle each have positioning elements that are oriented such that the cradle is keyed to fit within the basin and the basin is keyed to fit within the coolant container, each in a single predetermined orientation. The plurality of positioning elements on the basin may include a plurality of protrusions on an outer surface of the basin.

Abstract: A perfusion apparatus including a perfusion circuit that perfuses an organ or tissue has a compartment that supports an organ or tissue during perfusion, an internal cover, and an external cover that closes the apparatus. A wall portion may extend substantially perpendicularly between the internal cover and the external cover to define a document compartment between the internal cover, the external cover and the wall portion. A tamper evident seal will not permit the external cover to open without creating a record of whether the external cover has been opened after the tamper evident seal has been activated.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a coolant container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: An organ perfusion apparatus may include at least two tubes connected to an organ or tissue. A method of perfusing an organ or tissue may include connecting a first end of each of the at least two tubes to an organ or tissue, applying a fluid motive force to a perfusion fluid in the two tubes to force the fluid through the two tubes into the organ or tissue, and perfusing the organ or tissue through the at least two tubes such that the fluid motive force, provided by, e.g., a pump, and backpressure generated by the organ or tissue, establishes a flow balance between the at least two tubes. The flow balance may be altered without altering the fluid motive force that is applied.