Abstract: The invention provides polyamides which bind genes having expanded oligonucleotide repeat sequences, which binding modulates transcription. The invention further provides methods of modulation of the transcription of such genes, and the use of polyamides as therapeutic agents to treat diseases associated with such genes.

Abstract: Methods are provided for interfering with a hypoxia-mediated transcriptional pathway using an agent that binds to a hypoxia response element and inhibits transcription of a hypoxia inducible gene associated therewith. Also provided are methods of treating a patient with a solid tumors, and compositions useful for treating a patient having solid tumors, including, for example, by administering an agent that binds to a hypoxia response element in a cell. Agents for the methods of the invention are provided including compositions comprising a pyrrole imidazole polyamide or a pharmaceutically acceptable salt or complex thereof.

Abstract: Methods are provided for decreasing the rate or inhibiting neoplastic cell proliferation by reducing or inhibiting histone H4 gene expression or histone H4 activity. Also provided are methods of treating a patient with a neoplastic disease, and compositions useful for treating a cancer patient, including, for example, a composition containing small interfering RNA molecules that reduce or inhibit histone H4 expression in a cell or a composition containing a pyrrole-imidazole polyamide operatively linked to a chemotherapeutic molecule.

Abstract: Methods and compositions are provided for forming complexes between dsDNA and novel DNA-binding polymers comprising N-terminal thiophene-containing moieties which exhibit selectivity for T-A base pairs. By appropriate choice of target sequences and DNA-binding polymers, complexes comprising polymer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.

Abstract: Methods and compositions are provided for forming complexes between dsDNA and novel oligomers comprising fused six-membered rings. By appropriate choice of target sequences and oligomers, complexes comprising oligomer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.