Patents by Inventor Peter Diederik Jan Grootenhuis

Peter Diederik Jan Grootenhuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110098328
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: October 28, 2010
    Publication date: April 28, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Nicole Hilgraf, Peter Diederik Jan Grootenhuis, Mehdi Numa, Dean Stamos, Corey Anderson, Tara Whitney
  • Publication number: 20100144798
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: August 20, 2009
    Publication date: June 10, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Frederick F. VanGoor, Sara Sabina Hadida Ruah, Ashvani Kumar Singh, Eric R. Olson, Lewis Ray Makings, Jesus E. Gonzalez, III, James Arvid Rader, Fred Chambers, III, Mark Thomas Miller, Peter Diederik Jan Grootenhuis, Yahua Liu
  • Patent number: 7678802
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: March 16, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E. Gonzalez, III, Dean Mitchell Wilson, Andreas Peter Termin, Peter Diederik Jan Grootenhuis, Yulian Zhang, Benjamin John Petzoldt, Lev Tyler Dewey Fanning, Timothy Donald Neubert, Roger Tung, Esther Martinborough, Nicole Zimmerman
  • Publication number: 20040248739
    Abstract: Compounds of formula (I), wherein the substituents R1, R2, R3, R4 and Z and the suffixes n and m are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomers of those compounds are suitable for use as herbicides.
    Type: Application
    Filed: July 14, 2004
    Publication date: December 9, 2004
    Inventors: Jurgen Schaetzer, Martin Eberle, Jean Wenger, Sabine Berteina-Raboin, Kurt Nebel, Andre Stoller, Roger Graham Hall, Steven Scott Bondy, Daniel Dennis Comer, Julie Elizabeth Penzotti, Peter Diederik Jan Grootenhuis
  • Publication number: 20040248890
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 3, 2004
    Publication date: December 9, 2004
    Inventors: Jesus E. Gonzalez, Dean Mitchell Wilson, Andreas Peter Termin, Peter Diederik Jan Grootenhuis, Yulian Zhang, Benjamin John Petzoldt, Lev Tyler Dewey Fanning, Timothy Donald Neubert, Roger Tung, Esther Martinborough, Nicole Zimmermann
  • Patent number: 6034067
    Abstract: The invention relates to a compound having formula (I), wherein A, B, X, N, Z and Q are defined as described in the description. The compounds of the invention have anticoagulant activity and can be used in treating or preventing thrombin-related diseases.
    Type: Grant
    Filed: August 12, 1998
    Date of Patent: March 7, 2000
    Assignee: Akzo Nobel, N.V.
    Inventors: Peter Diederik Jan Grootenhuis, Adrianus Petrus Antonius de Man, Anton Egbert Peter Adang
  • Patent number: 5864488
    Abstract: The three-dimensional structure of human chorionic gonadotrophin (hCG) has been determined by X-ray crystallography and the coordinates of the individual atoms are presented. Analogues of hCG and other glycoprotein hormones sharing a similar .alpha.-subunit structure are produced by inputting chemical changes to the structure into a computer loaded with three-dimensional molecular simulation software and representing visually on a computer display. The three-dimensional structures of the original glycoprotein and the chemically modified analogues are compared, and those analogues wherein the three-dimensional configuration and spatial arrangement of regions involved in receptor binding and signal transduction remain substantially preserved are selected for synthesis by molecular biology techniques and screening for biological activity. Glycoprotein analogues with additional glycosylation sites, and deletion of non-essential hairpins are disclosed.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: January 26, 1999
    Assignee: University Court of the University of Glasgow
    Inventors: Neil William Isaacs, Adrian Jonathan Lapthorn, Deborah Claire Harris, Peter Diederik Jan Grootenhuis