Patents by Inventor PETER DORNAN

PETER DORNAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diol desymmetrization by nucleophilic aromatic substitution
    Patent number: 12552808
    Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound Y that can be used to prepare them where the variable R1 is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof, compound A2, and salts and solvates thereof, and compound A3 and salts and solvates thereof.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: February 17, 2026
    Assignee: AMGEN INC.
    Inventors: Matthew G. Beaver, Joseph Michael Dennis, Peter Dornan, Steven Mennen, Jason S. Tedrow, Neil F. Langille, Carolyn Michelle Cohen, Andreas Rene Rotheli
  • Process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
    Patent number: 12459896
    Abstract: Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A
    Type: Grant
    Filed: December 19, 2024
    Date of Patent: November 4, 2025
    Assignee: AMGEN INC.
    Inventors: Austin Gerald Smith, Padmini Kavuru Ananthoji, Peter Dornan, Xijie Dai
  • PROCESS FOR PREPARING 4-METHYL-2-PROPAN-2-YL-PYRIDINE-3-CARBONITRILE
    Publication number: 20250206705
    Abstract: Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A
    Type: Application
    Filed: December 19, 2024
    Publication date: June 26, 2025
    Applicant: AMGEN INC.
    Inventors: Austin Gerald SMITH, Padmini Kavuru ANANTHOJI, Peter DORNAN, Xijie DAI
  • A PROCESS FOR PREPARING 4-METHYL-2-PROPAN-2-YL-PYRIDINE-3-CARBONITRILE
    Publication number: 20250188036
    Abstract: Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A
    Type: Application
    Filed: March 6, 2023
    Publication date: June 12, 2025
    Applicant: AMGEN INC.
    Inventors: Austin Gerald SMITH, Padmini KAVURU, Peter DORNAN, Xijie DAI
  • DIOL DESYMMETRIZATION BY NUCLEOPHILIC AROMATIC SUBSTITUTION
    Publication number: 20230365588
    Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound Y that can be used to prepare them where the variable R1 is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof, compound A2, and salts and solvates thereof, and compound A3 and salts and solvates thereof.
    Type: Application
    Filed: September 1, 2021
    Publication date: November 16, 2023
    Applicant: AMGEN INC.
    Inventors: MATTHEW G. BEAVER, JOSEPH MICHAEL DENNIS, PETER DORNAN, STEVEN MENNEN, JASON S. TEDROW, NEIL F. LANGILLE, CAROLYN MICHELLE COHEN, ANDREAS RENE ROTHELI