Abstract: This disclosure describes systems and methods for managing a move of a patient being monitored or treated by a medical system, such as a medical ventilator. The disclosure describes a novel approach for preventing a patient from being moved from a first location to second different location that is connected to a monitoring and/or treatment system, before all of the necessary hoses have been disconnected from the patient. Further, the disclosure describes a novel approach of ensuring that all of the necessary hoses are reconnected to a patient being monitored or treated by a monitoring and/or treatment system after being moved from the first location to the second different location.

Abstract: This disclosure describes systems and methods for determining patient fatigue during ventilation of a patient. The disclosure describes novel notification and/or management of patient fatigue during ventilation. Further, the disclosure describes system and methods for preventing diaphragm fatigue or weakness.

Abstract: Position-based rendering apparatus and method for multi-die/GPU graphics processing. For example, one embodiment of a method comprises: distributing a plurality of graphics draws to a plurality of graphics processors; performing position-only shading using vertex data associated with tiles of a first draw on a first graphics processor, the first graphics processor responsively generating visibility data for each of the tiles; distributing subsets of the visibility data associated with different subsets of the tiles to different graphics processors; limiting geometry work to be performed on each tile by each graphics processor using the visibility data, each graphics processor to responsively generate rendered tiles; and wherein the rendered tiles are combined to generate a complete image frame.

Abstract: A blade track assembly is disclosed. The blade track assembly comprises a plurality of ceramic matrix composite blade track segments arranged circumferentially adjacent to one another around a central axis. Each of the blade track segments includes an arcuate runner extending in a circumferential direction around a portion of the central axis and is coupled to circumferentially adjacent blade track segments.

Abstract: This disclosure describes systems and methods for determining patient fatigue during ventilation of a patient. The disclosure describes novel notification and/or management of patient fatigue during ventilation. Further, the disclosure describes system and methods for preventing diaphragm fatigue or weakness.

Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Apparatus and method for simultaneous command streamers. For example, one embodiment of an apparatus comprises: a plurality of work element queues to store work elements for a plurality of thread contexts, each work element associated with a context descriptor identifying a context storage region in memory; a plurality of command streamers, each command streamer associated with one of the plurality of work element queues, the command streamers to independently submit instructions for execution as specified by the work elements; a thread dispatcher to evaluate the thread contexts including priority values, to tag each instruction with an execution identifier (ID), and to responsively dispatch each instruction including the execution ID in accordance with the thread context; and a plurality of graphics functional units to independently execute each instruction dispatched by the thread dispatcher and to associate each instruction with a thread context based on its execution ID.

Abstract: The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation.

Abstract: Methods and systems are provided for determining fluid administration. The system may determine fluid administration based on the fluid responsiveness and regional oxygen saturation of a subject. The system may receive the fluid responsiveness and regional oxygen saturation from external sources or may determine one or both based on received physiological signals. In some embodiments, the system may determine whether to administer fluid based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the amount of fluid to administer based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the effectiveness of fluid administration. In some embodiments, the system may provide an indication of the determined fluid administration so that a care-giver can implement the appropriate fluid administration. In some embodiments, the system may control the fluid administration based on its determination.

Abstract: The present disclosure combines the advantages of a hybrid mode of ventilation with an automatic determination of an appropriate spontaneous breath type in response to one or more patient based criteria. Specifically, when the ventilator is delivering a spontaneous breath type, a determination may be made as to whether predetermined ventilatory criteria have been met. Based on the determination the ventilator may deliver one of any number of spontaneous breath types.

Abstract: Methods and systems are provided for determining fluid administration. The system may determine fluid administration based on the fluid responsiveness and regional oxygen saturation of a subject. The system may receive the fluid responsiveness and regional oxygen saturation from external sources or may determine one or both based on received physiological signals. In some embodiments, the system may determine whether to administer fluid based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the amount of fluid to administer based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the effectiveness of fluid administration. In some embodiments, the system may provide an indication of the determined fluid administration so that a care-giver can implement the appropriate fluid administration. In some embodiments, the system may control the fluid administration based on its determination.

Abstract: This disclosure describes systems and methods for providing drive pressure ventilation of a patient. The disclosure describes a novel breath type that provides a spontaneous breath type that allows for the calculation of drive pressure that does not require invasive monitoring.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Various embodiments enable loop processing in a command processing block of the graphics hardware. Such hardware may include a processor including a command buffer, and a graphics command parser. The graphics command parser to load graphics commands from the command buffer, parse a first graphics command, store a loop count value associated with the first graphics command, parse a second graphics command and store a loop wrap address based on the second graphics command. The graphics command parser may execute a command sequence identified by the second graphics command, parse a third graphics command, the third graphics command identifying an end of the command sequence, set a new loop count value, and iteratively execute the command sequence using the loop wrap address based on the new loop count value.

Abstract: Methods and systems are presented for monitoring a clinical procedure using regional blood oxygen saturation (rSO2) of a subject. The rSO2 of a subject is monitored, and clinical information is received, indicating that the subject is undergoing a clinical procedure (e.g., an infusion pump procedure for sodium nitroprusside administration). A change in the rSO2 of the subject is detected, which may be indicative of a circulatory system impairment (e.g., elevated venous oxygen saturation) caused by the clinical procedure. Status information, which may be indicative of an increased risk of a physiological event (e.g., cyanide toxicity) is determined for the subject based on the clinical information and the detected change in the rSO2 of the subject. Corrective actions may be triggered based on the status information in order to reduce the increased risk. The corrective actions may be implemented as smart prompt or closed loop systems.

Abstract: An adjustably-sized and shaped picture frame formed of corner pieces around which are looped or woven one or more filaments such as colored yarns to form the frame borders. The frames created can be customized to various shapes and sizes. The corner pieces may be molded or molded and machined, and may have a diamond shape with inner side edges that align with outer corners of a sheet of artwork. The filament is woven around posts on both a front face and an outer corner of the corner pieces. A chamfer under a lower face of each corner piece may be used to secure free ends of the filament.

Abstract: This disclosure describes systems and methods for providing an optimized proportional assist breath type during ventilation of a patient. The disclosure describes a novel breath type that delivers a target airway pressure calculated based on a desired patient effort range to a triggering patient.

Abstract: This disclosure describes systems and methods for providing an optimized proportional assist breath type during ventilation of a patient. The disclosure describes a novel breath type that delivers a target airway pressure calculated based on a desired patient effort range to a triggering patient.

Abstract: This disclosure describes systems and methods for controlling pressure and/or flow during exhalation. The disclosure describes novel exhalation modes for ventilating a patient.

Abstract: A blade includes both a motherboard and daughter card to allow the combined functionality to be incorporated into a single black for size reduction. Standoffs couple the daughter card to the motherboard. Cantilever portions of the motherboard and daughter card exist between the standoffs and terminals of the motherboard and daughter card. The cantilever portions bend to accommodate any misalignment between the terminals of the motherboard and the daughter card and mating connectors of a bulkhead or printed circuit board backplane.