Abstract: The present invention refers to a seal ring for a mechanical seal, comprising a base body (2), a first layer (3) applied to a first face side (2a) of a base body (2), and a second layer (4) applied to a second face side (2b) of the base body (2), wherein at least one of the layers (3) is configured as a slide surface of the seal ring. Furthermore, the present invention refers to a method for producing such a seal ring.

Abstract: A slide ring seal arrangement comprises a rotationally fixed slide ring (4) and a slide ring (11), which is provided for rotating together with a rotating component, these slide rings each being held in a loose seat and interacting, in, in essence, radially oriented sealing surfaces, which are prestressed with a main prestressing force while in contact with one another. Each slide ring, on its front face that faces away from the sealing surface, is axially supported on a supporting part (14, 17) via an annular bearing surface (16, 20) provided between the respective supporting part and the adjacent front face of the respective slide ring. A load ratio (d12?dH2)/(d12?d22) of =2.0, preferably between 0.8 and 2.0, preferably no greater than between 1.0 and 1.5, more preferably approximately 1.3 is maintained on the bearing surface (16, 20). The measurement (d1?d2) of each bearing surface (16, 20) is equal to =10 mm, preferably between 0.2 and 2.0, preferably no more than approximately 0.6 mm.

Abstract: The invention relates to a slide ring seal arrangement comprising: a first stationary slide ring (2) having a first slide surface (2a), a second rotating slide ring (3) having a second slide surface (3a), wherein the rotating slide ring (3) rotates together with a rotating component (10) and wherein the slide surfaces (2a, 3a) of the slide rings (2, 3) are disposed opposite of each other and define a sealing gap (4) between each other, a dynamic secondary seal (13) that is arranged on a side (2b) of the stationary slide ring (2) facing away from the sealing gap (4) and seals a housing sealing region (12), a pretensioning device (7) that applies a pretension in the axial direction onto the stationary slide ring (2), and a filter element (14; 24) that has a substantially ring shape and is arranged in the radial direction further from a rotational axis (X-X) than the housing sealing region (12), in order to prevent dirt particles from depositing on the secondary seal (13) or on the housing sealing region (12).

Abstract: A slide ring seal arrangement comprises a rotationally fixed slide ring (4) and a slide ring (11), which is provided for rotating together with a rotating component, these slide rings each being held in a loose seat and interacting, in, in essence, radially oriented sealing surfaces, which are prestressed with a main prestressing force while in contact with one another. Each slide ring, on its front face that faces away from the sealing surface, is axially supported on a supporting part (14, 17) via an annular bearing surface (16, 20) provided between the respective supporting part and the adjacent front face of the respective slide ring. A load ratio (d12?dH2)/(d12?d22) of =2.0, preferably between 0.8 and 2.0, preferably no greater than between 1.0 and 1.5, more preferably approximately 1.3 is maintained on the bearing surface (16, 20). The measurement (d1?d2) of each bearing surface (16, 20) is equal to =10 mm, preferably between 0.2 and 2.0, preferably no more than approximately 0.6 mm.

Abstract: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.

Abstract: A mechanical seal assembly including at least one pair of co-operating seal rings, one of which is provided for common rotation with a rotating component and the other of which is provided rotationally fixed at a stationary component. One of the seal rings is axially movable and axially biased with a biasing force against the other seal ring, the biasing force being transmittable through a force transmitting ring to the respective seal ring, in order to bias facing sliding surfaces of the seal rings, between which a sealing gap is formed during operation, in a mutual sealing engagement, and a secondary sealing assembly provided at the force transmitting ring for sealing the axially movable seal ring with respect to at least one circumferential guiding surface of a guiding component guiding the movement of the seal ring and the force transmitting ring.

Abstract: A dual seal assembly, in particular for sealing a gas compressor, includes a first mechanical seal assembly including a pair of co-operating seal rings, one of which is provided for common rotation with a rotating component and the other of which is provided rotationally fixed at a stationary component. A second mechanical seal assembly includes a pair of co-operating seal rings, one of which is provided for common rotation with a rotating component and the other of which is provided rotationally fixed at a stationary component. One of the seal rings is axially movable and axially biased with a biasing force against the respectively other seal ring to bias facing sliding surfaces of the seal ringss in a mutual sealing engagement. A secondary sealing assembly is provided for sealing the axially movable seal ring with respect to at least one circumferential guiding surface of a guiding component.

Abstract: The invention relates to estradiol prodrugs of general formula (I), in which group Z is bonded to the steroid, process for their production, pharmaceutical compositions that contain these compounds, as well as their use for the production of pharmaceutical agents with estrogenic action.

Abstract: The present invention describes non-steroidal compounds of the general formula (I) in which A is in which X1 means one or more groups on the phenyl ring and represents independently of one another a halogen, OH, (C1-C4)alkyl, (C1-C4)alkyl-O, (C3-C6)cycloalkyl-O, (C1-C14)acyl-O, (C1-C4)alkenyl, (C1-C4)alkynyl, perfluoro(C1-C4)alkyl radical, —CHO or CN, and X2 means one or more groups on the phenyl ring and represents independently of one another an H, halogen, OH, (C1-C4)alkyl, (C1-C4)alkyl-O, (C1-C4)alkenyl, (C1-C4)alkynyl, perfluoro-(C1-C4)alkyl radical, —CHO or CN, as Estrogens.

Abstract: The invention relates to new quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone.

Abstract: This invention provides prodrugs of 8?-substituted estratrienes of general formula (I), in which the group Z is bonded to the steroid, process for their production, pharmaceutical compositions that contain these compounds as well as use thereof. The compounds of general formula I according to the invention do not bind to the estrogen receptor ? and/or ?. They bind to carbonic anhydrases and inhibit these enzymes.

Abstract: A secondary sealing element comprises a base body (12) made of a synthetic material and comprising a base portion (13) and a seal portion (14) which each comprise coaxially aligned, axially adjacent through bores (17, 31) for the passage of a component, and an annular disc element (25) accommodated in the base portion and comprising a through bore (30) coaxially aligned with the through bores in the base and seal portions and being made of a material which differs from that of the base body. In the unloaded state, the through bore (30) of the annular disc element (25) has a radial dimension d which is greater than that D2 of the through bore (31) in the seal portion (14) and smaller than that D1 in the base portion (13) of the base body (12). The annular disc element consists of a carbon material. An important field of application for the secondary sealing element is that of mechanical face seals for sealing relatively moveable components.

Abstract: New 17?-fluorosteroid compounds of formula (I) are disclosed: wherein R1 denotes H or methyl; R2 and R3 each denote H, Cl or methyl; and either a double bond or a single bond is present between C-6 and C-7 and also C-9 and C-10 of the steroid ring system respectively. These compounds have an activity profile with hybrid character so that they act as inhibitors for 5?-reductase and as high potency gestagens. Pharmaceutical compositions containing them are disclosed. They are suitable for treatment of conditions, which are caused by high levels of androgen in organs and tissues. These new compounds can be used in combination with other hormonal substances, such as estrogens, testosterone and other androgens, as contraceptives and for other applications.

Abstract: 17-methylene-4-azasteroid compounds of formula I: wherein R20 denotes fluoro, chloro or bromo R20a denotes hydrogen, R10 and R4 each denote a hydrogen atom or a methyl group, and R1 and R2 each denote a hydrogen atom or together denote an additional bond, are useful for treating diseases or conditions caused by excessive androgen levels, such as acne, prostate diseases, alopecia and hirsutism, as well as gynecological conditions. Methods of synthesizing the new 17-methylene-4-azasteroid compounds are described.

Abstract: Compounds of Formula 1 are useful in the treatment of inflammation.

Abstract: The present invention relates to non-steroidal progesterone receptor modulators of the general formula I, a process for their preparation, the use of the progesterone receptor modulators for producing medicaments, and pharmaceutical compositions comprising these compounds. The compounds according to the invention are suitable for the therapy and prophylaxis of gynaecological disorders such as endometriosis, leiomyomas of the uterus, dysfunctional bleeding and dysmenorrhoea, and for the therapy and prophylaxis of hormone-dependent tumours and for use for female fertility control and for hormone replacement therapy.

Abstract: Compounds of Formula 1 are useful in the treatment of inflammation.

Abstract: are useful in the treatment of inflammation.

Abstract: The invention relates to estradiol prodrugs of general formula (I), in which group Z is bonded to the steroid, process for their production, pharmaceutical compositions that contain these compounds, as well as their use for the production of pharmaceutical agents with estrogenic action.

Abstract: This invention relates to steroid prodrugs with androgenic action of general formula (I), in which group Z is bonded to the steroid, pharmaceutical compositions that contain these compounds as well as their use for the production of pharmaceutical agents with androgenic action.