Patents by Inventor Peter Droge
Peter Droge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11414681Abstract: The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in SEQ ID NO: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods of recombining a nucleic acid of interest into a target nucleic acid in the presence of the mutant lambda integrase and sequence specific recombination kits.Type: GrantFiled: June 3, 2019Date of Patent: August 16, 2022Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Farid Ghadessy, Jia Wei Siau, Peter Droge, Harshyaa Makhija, Shree Harsh Vijaya Chandra, Sabrina Peter
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Publication number: 20210339495Abstract: The disclosure relates to a wood material panel hot press for producing a wood material panel, wherein the wood material panel hot press has an inlet side and an outlet side, and is designed to press a blank supplied on the inlet side in order to form a wood material panel. According to the invention, a temperature measurement device is provided which is designed to automatically measure the temperature (T) of the wood material panel on the outlet side in a spatially resolved manner.Type: ApplicationFiled: July 14, 2021Publication date: November 4, 2021Inventor: Peter DRÖGE
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Patent number: 11097502Abstract: The disclosure relates to a wood material panel hot press for producing a wood material panel, wherein the wood material panel hot press has an inlet side and an outlet side, and is designed to press a blank supplied on the inlet side in order to form a wood material panel. According to the invention, a temperature measurement device is provided which is designed to automatically measure the temperature (T) of the wood material panel on the outlet side in a spatially resolved manner.Type: GrantFiled: August 31, 2017Date of Patent: August 24, 2021Assignee: SWISS KRONO TEC AGInventor: Peter Dröge
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Patent number: 11078493Abstract: The present invention provides a method of stably integrating a DNA sequence of interest into a target genomic DNA sequence of a host cell, wherein the target genomic DNA sequence comprises a nucleotide sequence that is at least 80% homologous to the sequence as set forth in SEQ ID NO:1, as well as a kit for use in said method. Also provided is a method of generating a circular DNA construct essentially consisting of a DNA sequence of interest and a nucleotide sequence that is at least 80% homologous to the sequence as set forth in SEQ ID NO:3.Type: GrantFiled: June 21, 2017Date of Patent: August 3, 2021Assignee: Nanyang Technological UniversityInventors: Harshyaa Makhija, Peter Droge
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Publication number: 20200063165Abstract: The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in SEQ ID NO: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods of recombining a nucleic acid of interest into a target nucleic acid in the presence of the mutant lambda integrase and sequence specific recombination kits.Type: ApplicationFiled: June 3, 2019Publication date: February 27, 2020Inventors: Farid GHADESSY, Jia Wei SLAU, Peter DROGE, Harshyaa MAKHIJA, Shree Harsh VIJAYA CHANDRA, Sabrina PETER
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Patent number: 10344301Abstract: The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in SEQ ID NO: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods of recombining a nucleic acid of interest into a target nucleic acid in the presence of the mutant lambda integrase and sequence specific recombination kits.Type: GrantFiled: August 11, 2015Date of Patent: July 9, 2019Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Farid Ghadessy, Jia Wei Siau, Peter Droge, Harshyaa Makhija, Shree Harsh Vijaya Chandra, Sabrina Peter
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Publication number: 20190176425Abstract: The disclosure relates to a wood material panel hot press for producing a wood material panel, wherein the wood material panel hot press has an inlet side and an outlet side, and is designed to press a blank supplied on the inlet side in order to form a wood material panel. According to the invention, a temperature measurement device is provided which is designed to automatically measure the temperature (T) of the wood material panel on the outlet side in a spatially resolved manner.Type: ApplicationFiled: August 31, 2017Publication date: June 13, 2019Inventor: Peter DRÖGE
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Publication number: 20170362606Abstract: The present invention provides a method of stably integrating a DNA sequence of interest into a target genomic DNA sequence of a host cell, wherein the target genomic DNA sequence comprises a nucleotide sequence that is at least 80% homologous to the sequence as set forth in SEQ ID NO:1, as well as a kit for use in said method. Also provided is a method of generating a circular DNA construct essentially consisting of a DNA sequence of interest and a nucleotide sequence that is at least 80% homologous to the sequence as set forth in SEQ ID NO:3.Type: ApplicationFiled: June 21, 2017Publication date: December 21, 2017Inventors: Harshyaa Makhija, Peter Droge
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Publication number: 20170327847Abstract: The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in SEQ ID NO: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods of recombining a nucleic acid of interest into a target nucleic acid in the presence of the mutant lambda integrase and sequence specific recombination kits.Type: ApplicationFiled: August 11, 2015Publication date: November 16, 2017Inventors: Farid GHADESSY, Jia Wei SIAU, Peter DROGE, Harshyaa MAKHIJA, Shree Harsh VIJAYA CHANDRA, Sabrina PETER
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Publication number: 20130133092Abstract: The present invention relates to a method of sequence specific recombination of DNA in eukaryotic cells utilizing att sequences from the bacteriophage lambda. A particular embodiment of the invention relates to a method further comprising performing the sequence specific recombination of DNA with an Int and a Xis factor. The present invention further relates to vectors containing each of these sequences and their use as medicaments.Type: ApplicationFiled: November 1, 2012Publication date: May 23, 2013Inventor: Dr. Peter Droge
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Patent number: 7968341Abstract: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence into a cell, and performing the sequence specific recombination by a bacteriophage lambda integrase Int.Type: GrantFiled: November 28, 2003Date of Patent: June 28, 2011Assignees: Boehringer Ingelheim Pharma GmbH & Co KGInventors: Peter Dröge, Barbara Enenkel
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Patent number: 7846732Abstract: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence into a cell, and performing the sequence specific recombination by a bacteriophage lambda integrase Int.Type: GrantFiled: November 17, 2005Date of Patent: December 7, 2010Assignees: Boehringer Ingelheim Pharma KGInventors: Peter Dröge, Barbara Enenkel
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Patent number: 7491539Abstract: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence into a cell, and performing the sequence specific recombination by a bacteriophage lambda integrase Int.Type: GrantFiled: December 5, 2002Date of Patent: February 17, 2009Assignee: Boehringer Ingelheim Pharma KGInventors: Peter Dröge, Barbara Enenkel
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Publication number: 20080213821Abstract: A microfluidic system for separating, purifying and counting cell sub-populations, utilising steering of liquid flows in microfluidic channels in a cell focusing region (first dotted circle area); having the integration of the optical detection mechanism and a microchannel structure made from moulding. A master is photolithographically patterned on a soft PDMS silicon or polymer material. After being moulded and peeled off the master, the micro-channel structure is sealed on a hard substrate with openings punched through for wells (14, 12, 36, 38, 40). An optical detection region (20) discriminates different types of cells that have been formed into a single flow (30). Electromagnetic fields are used to steer (32) the flows of cells according to the signals from the optical detection region into branch channels leading to the punched wells for separate collection. The system can have parallel systems that increase throughput or cascade systems to provide several analysis steps.Type: ApplicationFiled: May 6, 2005Publication date: September 4, 2008Applicant: NANYANG TECHNOLOGICAL UNIVERSITYInventors: Ai Qun Liu, Xiao Jun Liang, Xu Ming Zhang, Yi Sun, Peter Droge
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Publication number: 20070148773Abstract: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence into a cell, and performing the sequence specific recombination by a bacteriophage lambda integrase Int.Type: ApplicationFiled: November 28, 2003Publication date: June 28, 2007Inventors: Peter Dröge, Barbara Enenkel
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Publication number: 20060078968Abstract: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence into a cell, and performing the sequence specific recombination by a bacteriophage lambda integrase Int.Type: ApplicationFiled: November 17, 2005Publication date: April 13, 2006Inventors: Peter Droge, Barbara Enenkel
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Publication number: 20040110293Abstract: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence into a cell, and performing the sequence specific recombination by a bacteriophage lambda integrase Int.Type: ApplicationFiled: December 5, 2002Publication date: June 10, 2004Inventors: Peter Droge, Barbara Enenkel
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Publication number: 20030027337Abstract: The present invention relates to a method of sequence specific recombination of DNA in eukaryotic cells utilizing att sequences from the bacteriophage lambda. A particular embodiment of the invention relates to a method further comprising performing the sequence specific recombination of DNA with an Int and a Xis factor. The present invention further relates to vectors containing each of these sequences and their use as medicaments.Type: ApplicationFiled: February 25, 2002Publication date: February 6, 2003Applicant: Boehringer Ingelheim Pharma KGInventors: Peter Droge, Nicole Christ, Elke Lorbach