Patents by Inventor Peter E. Neilsen

Peter E. Neilsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugated peptide nucleic acids having enhanced cellular uptake
    Patent number: 6686442
    Abstract: Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: February 3, 2004
    Inventors: Peter E. Neilsen, Helle Knudsen
  • Conjugated peptide nucleic acids having enhanced cellular uptake
    Publication number: 20020188101
    Abstract: Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.
    Type: Application
    Filed: November 19, 2001
    Publication date: December 12, 2002
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Peter E. Neilsen, Helle Knudsen