Patents by Inventor Peter E. Nielsen

Peter E. Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Double-stranded peptide nucleic acids
    Patent number: 6228982
    Abstract: A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: May 8, 2001
    Inventors: Benget Norden, Pernilla Wittung, Ole Buchardt, Michael Egholm, Peter E. Nielsen, Rolf Berg
  • Methods of bacterial gene function determination using peptide nucleic acids
    Patent number: 6190866
    Abstract: Methods of and compositions for killing or inhibiting the growth of a bacteria are disclosed. Methods of determing bacterial gene functions are also disclosed. The methods comprise the use of peptide nucleic acid that is targeted to mRNA and/or rRNA. In certain embodiments, methods include the use of one or more separate antibiotics.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: February 20, 2001
    Inventors: Peter E. Nielsen, Liam Good
  • Histidine-containing peptide nucleic acids
    Patent number: 6107470
    Abstract: Peptide nucleic acids containing histidine moieties are provided. These compounds have applications including diagnostics, research and potential therapeutics.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: August 22, 2000
    Inventors: Peter E. Nielsen, Ole Buchardt, deceased, Rolf H. Berg, Michael Egholm
  • Peptide nucleic acids complexes of two peptide nucleic acid strands and one nucleic acid strand
    Patent number: 5986053
    Abstract: Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 1999
    Assignees: Isis Pharmaceuticals, Inc., Peter E. Nielsen
    Inventors: David J. Ecker, Ole Buchardt, Michael Egholm, Peter E. Nielsen, Rolf H. Berg, Niels E. Mollegaard
  • Peptide nucleic acids
    Patent number: 5773571
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
    Type: Grant
    Filed: February 1, 1996
    Date of Patent: June 30, 1998
    Inventors: Peter E. Nielsen, Ole Buchardt, Michael Egholm, Rolf H. Berg
  • Cleaving double-stranded DNA with peptide nucleic acids
    Patent number: 5641625
    Abstract: Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: June 24, 1997
    Assignees: ISIS Pharmaceuticals, Inc., Peter E. Nielsen
    Inventors: David J. Ecker, Ole Buchardt, Michael Egholm, Peter E. Nielsen, Rolf H. Berg, Niels E. Mollegaard
  • Peptide nucleic acids
    Patent number: 5539082
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: July 23, 1996
    Inventors: Peter E. Nielsen, Ole Buchardt, Michael Egholm, Rolf H. Berg