Abstract: The invention relates to an irrigation hose intended for irrigating soils and made of a material comprising a thermoplastic, the irrigation openings being produced by means of a laser. The invention likewise relates to a method and an installation for producing such an irrigation hose for this purpose.

Abstract: A filter device, in particular a return line suction filter, has at least one filter housing (3) receiving a filter element (17) defining a longitudinal axis. The filter element has an end cap with an enclosure at one filter element end enclosing an end edge of the filter material (39) and fixed to an element receptacle (5) connected to the filter housing (3) for fixing the location of the filter element (17) in its functional position. The element receptacle (5) and the associated end cap (21) of the filter element (17) have design irregularities (63, 65) adapted to each other at their parts (23, 47) engaging each other in the functional position of the filter element (17). The irregularities enable the engagement in a positional alignment to each other.

Abstract: The invention relates to a filter device, in particular a return line suction filter, having at least one filter housing (3) in which a filter element (17) defining a longitudinal axis in the form of a filter cartridge can be received and comprises an enclosure at at least one end thereof for the corresponding end cap (21) forming the end edge of the filter material (39) and that can be fixed to an element receptacle (5) connected to the filter housing (3) for fixing the location of the filter element (17) in the functional position thereof, characterized in that the element receptacle (5) and the associated end cap (21) of the filter element (17) have design irregularities (63, 65) adapted to each other at the parts thereof (23, 47) engaging each other in the functional position of the filter element (17), said irregularities enabling the engagement in a positional alignment to each other.

Abstract: This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.

Abstract: This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.

Abstract: This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.