Patents by Inventor Peter Edelman
Peter Edelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11911413Abstract: Pharmaceutical and veterinary compositions for oral administration comprising a therapeutically effective amount of at least one coxib together with a therapeutically effective amount of pentosan polysulfate or a pharmaceutically acceptable salt thereof are described. The compositions have application for the prophylaxis or treatment of pain and/or inflammation. There is also described a pharmaceutical or veterinary composition comprising a therapeutically effective amount of at least one coxib. The compositions in at least some forms may be lactose free and/or provided in a non-gelatin capsule. Further, there are provided methods for administration of a therapeutically effective amount of at least one coxib in combination with pentosan polysulfate or a pharmaceutically acceptable salt thereof for the prophylaxis or treatment of pain and/or inflammation.Type: GrantFiled: February 15, 2019Date of Patent: February 27, 2024Assignee: Proteobioactives Pty LimitedInventors: Peter Ghosh, Jack Edelman
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Medical devices having a bioresorbable coating layer with a pre-determined pattern for fragmentation
Patent number: 9597435Abstract: Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.Type: GrantFiled: May 4, 2009Date of Patent: March 21, 2017Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Peter Edelman, Afsar Ali -
Patent number: 9284409Abstract: In embodiments, medical devices have a surface that includes a catalytic material, and a non-fouling material attached to the surface. The non-fouling material can be released from the surface, for example, by cleavage of a bond connecting the material to the surface. The bond can be a chemical bond, such as a covalent bond.Type: GrantFiled: July 17, 2008Date of Patent: March 15, 2016Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Peter Edelman, Samuel Robaina
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Patent number: 9056006Abstract: A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets. Each leaflet includes) at least two polymers along at least one portion of the leaflet, and each leaflet has a composition gradient of each of the at least two polymers along at least one portion of the leaflet.Type: GrantFiled: July 1, 2013Date of Patent: June 16, 2015Assignee: Boston Scientific SciMed, Inc.Inventors: Peter Edelman, Horng-Ban Lin, Scott Fisher, Jeffrey S. Lindquist, Huisun Wang, Richard C. Gunderson
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Publication number: 20140005772Abstract: A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets. Each leaflet includes) at least two polymers along at least one portion of the leaflet, and each leaflet has a composition gradient of each of the at least two polymers along at least one portion of the leaflet.Type: ApplicationFiled: July 1, 2013Publication date: January 2, 2014Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Peter Edelman, Horng-Ban Lin, Scott Fisher, Jeffrey S. Lindquist, Huisun Wang, Richard C. Gunderson
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Patent number: 8574612Abstract: A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., target binding capacity) of the biologic macromolecules during processing, storage, handling, and/or delivery (e.g., implantation or insertion into a patient) of the medical device. Upon implantation or insertion into a patient's body, the temporary protective layer may dissolve to expose the biologic macromolecules to the physiologic environment.Type: GrantFiled: February 19, 2010Date of Patent: November 5, 2013Assignee: Boston Scientific Scimed, Inc.Inventor: Peter Edelman
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Patent number: 8444669Abstract: The disclosure pertains to a medical device deployment system comprising a restraint member which holds the embolic protection filter in a restrained, or partially collapsed, state for insertion into a lumen and transit to a desired deployment site. The restraint member comprises two or more portions which differ in their mechanical ability to resist the radial forces exerted by various portions of the medical device when it is in a restrained, or partially collapsed, state. The restraint member is maintained in a restraint configuration by an actuation member which engages portions of the restraint member lying on opposite sides of a generally axial gap until deployment of the medical device is desired. Withdrawal of the actuation member allows the restraint member to release the medical device which may then return to a deployed state. The invention also provides a method for assembling a medical device deployment system.Type: GrantFiled: September 21, 2009Date of Patent: May 21, 2013Assignee: Boston Scientific Scimed, Inc.Inventors: Peter Edelman, Lawrence Wasicek, Nayan Ashar, Husnija Mujkanovic, Eddie Sucgang
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Patent number: 8257777Abstract: Methods and devices for coating a medical device, such as a stent, including the steps of coating the medical device with a photoresist polymeric coating, irradiating a portion of the medical device, optionally applying a post-exposure bake step, and removing all or a portion of the coating from the irradiated portion of the medical device, if a positive photoresist coating material is used, or from a portion of the medical device not exposed to the radiation, if a negative photoresist coating material is used. The photoresist polymeric coating may optionally include a drug.Type: GrantFiled: April 10, 2008Date of Patent: September 4, 2012Assignee: Boston Scientific Scimed, Inc.Inventor: Peter Edelman
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Publication number: 20100268263Abstract: Embolic protection filters, filter membranes, and methods for making and using the same. An example embolic protection filter may include an elongate shaft having a proximal region and a distal region. A filter frame may be to the distal region. A filter membrane may be attached to the filter frame. The filter membrane may have a plurality of apertures formed therein. The filter membrane may include a polymer having a bulk portion and a surface portion. The surface portion may include a surface modification.Type: ApplicationFiled: April 21, 2009Publication date: October 21, 2010Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Peter Edelman, Nayan Ashar, Narin Anderson, Bradley White
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Publication number: 20100226953Abstract: A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., target binding capacity) of the biologic macromolecules during processing, storage, handling, and/or delivery (e.g., implantation or insertion into a patient) of the medical device. Upon implantation or insertion into a patient's body, the temporary protective layer may dissolve to expose the biologic macromolecules to the physiologic environment.Type: ApplicationFiled: February 19, 2010Publication date: September 9, 2010Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventor: Peter EDELMAN
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Publication number: 20100152711Abstract: The invention provides a medical device delivery system comprising an offset coupling region interposed between an elongated hypotube guide member or catheter and a support segment. The medical device to be delivered is disposed about the support segment and contained and/or constrained within a containment element. The medical device may be released from the containment element by moving an actuation element from a first position to a second position. The offset coupling region allows the actuation element to exit a lumen within the guide member and to engage the containment element in the first position while traveling along a line generally coaxial with the lumen of the guide member.Type: ApplicationFiled: August 27, 2009Publication date: June 17, 2010Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Allen Utke, Kyle Hendrikson, Peter Edelman, Ben Arcand, James Anderson, Ari Ryan
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Publication number: 20100152829Abstract: The disclosure pertains to a medical device deployment system comprising a restraint member which holds the embolic protection filter in a restrained, or partially collapsed, state for insertion into a lumen and transit to a desired deployment site. The restraint member comprises two or more portions which differ in their mechanical ability to resist the radial forces exerted by various portions of the medical device when it is in a restrained, or partially collapsed, state. The restraint member is maintained in a restraint configuration by an actuation member which engages portions of the restraint member lying on opposite sides of a generally axial gap until deployment of the medical device is desired. Withdrawal of the actuation member allows the restraint member to release the medical device which may then return to a deployed state. The invention also provides a method for assembling a medical device deployment system.Type: ApplicationFiled: September 21, 2009Publication date: June 17, 2010Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Peter Edelman, Lawrence Wasicek, Nayan Ashar, Husnija Mujkanovic, Eduardo Sucgang
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Publication number: 20100145437Abstract: The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.Type: ApplicationFiled: February 17, 2010Publication date: June 10, 2010Applicant: Boston Scientific Scimed, Inc.Inventors: Timothy S. Girton, Jeffrey S. Lindquist, David M. Knapp, Matt Heidner, Daniel Gregorich, Umang Anand, Peter Edelman, Matthew J. Miller, Raed Rizq, Jan Weber, Tracee Eidenschink, John J. Chen, Jaykeep Y. Kokate, Aparna Bhave, Kent D. Harrison, Graig L. Kveen, Benjamin Arcand, Michael Kuchling
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MEDICAL DEVICES HAVING A BIORESORBABLE COATING LAYER WITH A PRE-DETERMINED PATTERN FOR FRAGMENTATION
Publication number: 20090274743Abstract: Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.Type: ApplicationFiled: May 4, 2009Publication date: November 5, 2009Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Peter EDELMAN, Afsar ALI -
Publication number: 20090149942Abstract: An endoprosthesis, e.g., a stent, that includes a pro-healing surface and a temporary non-fouling material attached to the surface, and a method of making the same are disclosed.Type: ApplicationFiled: July 17, 2008Publication date: June 11, 2009Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Peter Edelman, Samuel Robaina
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Publication number: 20090118812Abstract: A method includes: providing a substrate, depositing a ceramic and an extractable material onto the substrate, forming a porous structure in the ceramic by removing the extractable material, and utilizing the ceramic in an endoprosthesis. An endoprosthesis, such as a stent, including a coating formed of a ceramic and an extractable material that can be removed from the coating to form voids is also disclosed.Type: ApplicationFiled: November 2, 2007Publication date: May 7, 2009Applicant: Boston Scientific Scimed, Inc.Inventors: Jaydeep Y. Kokate, Raed Rizq, Jay Rassat, Derek Sutermeister, Samuel Robaina, Peter Edelman, Tom Holman, Michael Kuehling, Yixin Xu
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Publication number: 20090076591Abstract: The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.Type: ApplicationFiled: September 19, 2007Publication date: March 19, 2009Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Timothy S. Girton, Jeffrey S. Lindquist, David M. Knapp, Matt Heidner, Daniel Gregorich, Umang Anand, Peter Edelman, Matthew J. Miller, Raed Rizq, Jan Weber, Tracee Eidenschink, John J. Chen, Jaykeep Y. Kokate, Aparna Bhave, Kent D. Harrison, Graig L. Kveen, Benjamin Arcand, Michael Kuehling
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Publication number: 20090018633Abstract: A protector for a medical device including a tubular member, the tubular member including a polymer matrix material and a scavenger for moisture, oxygen or a combination thereof dispersed in the polymer matrix material.Type: ApplicationFiled: July 10, 2007Publication date: January 15, 2009Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Jeffrey S. Lindquist, Peter Edelman
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Publication number: 20080254297Abstract: Methods and devices for coating a medical device, such as a stent, including the steps of coating the medical device with a photoresist polymeric coating, irradiating a portion of the medical device, optionally applying a post-exposure bake step, and removing all or a portion of the coating from the irradiated portion of the medical device, if a positive photoresist coating material is used, or from a portion of the medical device not exposed to the radiation, if a negative photoresist coating material is used. The photoresist polymeric coating may optionally include a drug.Type: ApplicationFiled: April 10, 2008Publication date: October 16, 2008Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventor: Peter Edelman
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Publication number: 20080095736Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.Type: ApplicationFiled: November 16, 2007Publication date: April 24, 2008Inventors: Chandrashekhar Pathak, Amarpreet Sawhney, Peter Edelman