Patents by Inventor Peter Edward Lobie

Peter Edward Lobie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule inhibitors of BCL-2-associated death promoter (BAD) phosphorylation
    Patent number: 11292773
    Abstract: The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: April 5, 2022
    Assignees: NATIONAL UNIVERSITY OF SINGAPORE, UNIVERSITY OF MYSORE, BANGALORE UNIVERSITY
    Inventors: Peter Edward Lobie, Vijay Kumar Pandey, Rangappa Kanchugarakoppal Subbegowda, Bassappa Salundi, Mohan Chakrabhavi Dhananjaya, Shobith Rangappa, Srinivasa Venkatachalaiah
  • Compounds useful in inhibiting human trefoil factor 3
    Patent number: 11141402
    Abstract: Disclosed herein are compounds of Formula I, wherein A, R1 to R6, and x to z have the meanings given in the description.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: October 12, 2021
    Assignees: National University of Singapore, University of Mysore, Bangalore University
    Inventors: Peter Edward Lobie, Vijay Kumar Pandey, Rangappa Kanchugarakoppal Subbegowda, Basappa, Mohan Chakrabhavi Dhananjaya, Shobith Rangappa
  • COMPOUNDS USEFUL IN INHIBITING HUMAN TREFOIL FACTOR 3
    Publication number: 20200147039
    Abstract: Disclosed herein are compounds of Formula I, wherein A, R1 to R6, and x to z have the meanings given in the description.
    Type: Application
    Filed: June 5, 2018
    Publication date: May 14, 2020
    Inventors: Peter Edward LOBIE, Vijay Kumar PANDEY, Rangappa KANCHUGARAKOPPALSUBBEGOWDA, Basappa BASAPPA, Mohan CHAKRABHAVI DHANANJAYA, Shobith RANGAPPA
  • SMALL MOLECULE INHIBITORS OF BCL-2- ASSOCIATED DEATH PROMOTER (BAD) PHOSPHORYLATION
    Publication number: 20200131139
    Abstract: The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.
    Type: Application
    Filed: April 18, 2018
    Publication date: April 30, 2020
    Inventors: Peter Edward Lobie, Vijay Kumar Pandey, Ranpappa Kanchugarakoppal Subbegowda, Bassappa Salundi, Mohan Chakrabhavi Dhananjaya, Shobith Rangappa, Srinivasa Venkatachalaiah
  • Compounds as modulator of JAK-STAT pathway, methods and applications thereof
    Patent number: 9604974
    Abstract: The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of employing the Formula I compounds for modulation of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in cancer cells, and the corresponding use of compound of Formula I as anti-cancer agents.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: March 28, 2017
    Assignees: UNIVERSITY OF MYSORE, NATIONAL UNIVERSITY OF SINGPORE, BANGALORE UNIVERSITY, CAMBRIDGE ENTERPRISE LTD
    Inventors: Kanchugarakoppal Subbegowda Rangappa, Basappa, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Hanumantharayappa Bharathkumar, Gautam Sethi, Andreas Bender, Peter Edward Lobie, Kam Man Hui, Alan Prem Kumar, Vijay Kumar Pandey, Julian Fuchs, Muthu Kumaraswamy Shanmugam, Krishna Bulusu, Xiaoyun Dai, Feng Li, Amudha Deivasigamani
  • COMPOUNDS AS MODULATOR OF JAK-STAT PATHWAY, METHODS AND APPLICATIONS THEREOF
    Publication number: 20160214968
    Abstract: The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of employing the Formula I compounds for modulation of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in cancer cells, and the corresponding use of compound of Formula I as anti-cancer agents.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 28, 2016
    Inventors: Kanchugarakoppal Subbegowda RANGAPPA, BASAPPA, Chakrabhavi Dhananjaya MOHAN, Shobith RANGAPPA, Hanumantharayappa BHARATHKUMAR, Gautam SETHI, Andreas BENDER, Peter Edward LOBIE, Kam Man HUI, Alan Prem KUMAR, Vijay Kumar PANDEY, Julian FUCHS, Muthu Kumaraswamy SHANMUGAM, Krishna BULUSU, Xiaoyun DAI, Feng LI, Amudha DEIVASIGAMANI
  • ANTI-NEOPLASTIC USES OF ARTEMIN ANTAGONISTS
    Publication number: 20150079106
    Abstract: The invention relates to methods for the prophylaxis and treatment of breast cancer using one or more antagonists of artemin function, such as anti-artemin polynucleotides or anti-artemin antibodies and antibody fragments, and uses of these antagonists. In particular, the invention relates to the resensitisation of therapy-resistance breast cancer cells to anti-cancer therapies by antagonism of artemin functionality.
    Type: Application
    Filed: September 10, 2014
    Publication date: March 19, 2015
    Applicant: Auckland Uniservices Limited
    Inventor: Peter Edward LOBIE
  • POLYPEPTIDES AND POLYNUCLEOTIDES FOR ARTEMIN AND RELATED LIGANDS, AND METHODS OF USE THEREOF
    Publication number: 20150030605
    Abstract: The invention encompasses polypeptides, polynucleotides, and antibodies, for Artemin and related ligands, including Persephin (PSPN). The invention also encompasses expression vectors and host cells for producing these polypeptides, polynucleotides, or antibodies. The invention further encompasses diagnostics and therapeutics, especially for cancer, and particularly breast cancer, colon cancer, prostate cancer, endometrial cancer, lung cancer, stomach cancer, liver cancer, and others, comprising one or more of the disclosed polypeptides, polynucleotides, antibodies, expression vectors, host cells, or compositions thereof. Particularly encompasses are inhibitors of Artemin and/or related ligands, and uses for these inhibitors.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 29, 2015
    Inventors: Liu Dongxu, Peter Edward Lobie
  • ANTI-NEOPLASTIC USES OF ARTEMIN ANTAGONISTS
    Publication number: 20120282266
    Abstract: The invention relates to methods for the prophylaxis and treatment of breast cancer using one or more antagonists of artemin function, such as anti-artemin polynucleotides or anti-artemin antibodies and antibody fragments, and uses of these antagonists. In particular, the invention relates to the resensitisation of therapy-resistance breast cancer cells to anti-cancer therapies by antagonism of artemin functionality.
    Type: Application
    Filed: October 15, 2010
    Publication date: November 8, 2012
    Applicant: AUCKLAND UNISERVICES LIMITED
    Inventor: Peter Edward Lobie