Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R1A, R1B, R1C, R1D, B1, R2A, R2B, R2C, R2D, and R2E are defined herein and Formula (II) wherein R1H, R1K, R1J, and R2L are defined herein.

Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B, R2C, B1, W, X, Y, Z are defined herein.

Abstract: A device and method for collecting, analyzing, and identifying chemical and biological samples in solid or liquid form is disclosed. The analysis compares the color change of Colorimetric Sensor Arrays (CSAs) over time with images for known materials/compounds contained in a library. The device can be used as a handheld or standalone device and integrates the sampling and detecting functions of the prior art into a single device that analyzes and identifies the sample without destroying it. The inventive volatile organic compound (VOC) technology device is also unique in that it relies on a comparison to a proprietary compound library that is supported by lab data. This compound library identifies the unique dye signature combinations that provide very accurate classification of a wide variety of chemical and biological agents.

Abstract: A bone correcting system which includes a first pin which can be connected to a bone at a first location; at least a second pin which can be connected to the bone at a second location at a distance from the first location; a telescopic fixation member which is coupled rigidly to the first and second pins for the purpose of fixing the mutual distance between the pins during the hardening phase, and which is coupled flexibly to the first and the second pins during a correction phase; and at least a first annular fixation member which is removably connected to the first pin and at least a second annular fixation member which is removably connected to the second pin for the purpose of adjusting the bone during the correction phase. This system provides an efficient, user-friendly and simple system for correcting bones, particularly in respect to bone hardening.

Abstract: The disclosure herein provides system, methods, and devices for generating debit cards. A debit card system for creating a plurality of debit cards comprises a debit card printer, a batch creation engine, a payment batches database, a deposit management engine, and a distribution engine, wherein the debit card printer comprises an imprinting mechanism, a magnetic strip writer, and a computer network interface. In an embodiment, the distribution engine is further configured to initiate creation of an alternate account on behalf of a recipient related to a debit card that is not activated within a predetermined amount of time, and to transmit to a deposit processing system instructions to enable a deposit into the alternate account of funds equal to a recipient payment amount.

Abstract: A self-contained, leak-proof sampling device and kit employing said device for collecting chemical and biological samples from various surfaces. The invention provides a sampling device and kit that may be employed to easily collect chemical and biological samples, safely transport the collected samples, safely dispense collected samples for analysis and provide optimum sample recovery. The sampling device is in the form of a leak proof container that comprises a lid and base. The lid contains a sterile absorbent collection means integrated into and positioned on the inside surface of the lid. The base contains a means to facilitate sample recovery from the absorbent collection means via compression and/or scraping of the absorbent collections means. Methods for employing the present invention are described herein.

Abstract: A self-contained, leak-proof sampling device and kit employing said device for collecting chemical and biological samples from various surfaces. The invention provides a sampling device and kit that may be employed to easily collect chemical and biological samples, safely transport the collected samples, safely dispense collected samples for analysis and provide optimum sample recovery. The sampling device is in the form of a leak proof container that comprises a lid and base. The lid contains a sterile absorbent collection means integrated into and positioned on the inside surface of the lid. The base contains a means to facilitate sample recovery from the absorbent collection means via compression and/or scraping of the absorbent collections means. Methods for employing the present invention are described herein.

Abstract: An array encoding system and method for use with high definition digital video data streams includes method and means for analyzing the incoming data stream, splitting the data stream in accordance with video complexity or other criteria, encoding each of the subsidiary data streams in accordance with a desired encoding standard, and combining the data streams to generate an output. The encoding system and method is particularly suited to encoding data streams to provide an output with is substantially consistent with the H.264 video communications standard. The system and method are scalable.

Abstract: An array encoding system and method for use with high definition digital video data streams includes method and means for analyzing the incoming data stream, splitting the data stream in accordance with video complexity or other criteria, encoding each of the subsidiary data streams in accordance with a desired encoding standard, and combining the data streams to generate an output. The encoding system and method is particularly suited to encoding data streams to provide an output with is substantially consistent with the H.264 video communications standard. The system and method are scalable.

Abstract: Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of self-orienting on a surface to improve the orientation of the ligand/receptor binding domains within the bioassay at the nanoscopic level. In a preferred embodiment, the molecularly compact polymer comprises a dendrimer polymer such as a fifth generation polyamidoamine dendrimer having exterior surface hydroxyl and amine functional groups, and the ligand/receptor comprises an antibody or Fab.

Abstract: Recombinant antibody fragments (rFabs) specific to botulinum types A and B oxin complexes are provided. These rFabs are useful as immunosensors for detecting botulinum toxin in food, health care, and military applications. The DNA sequences coding for the rFabs are also disclosed.