Abstract: An ergonomic manual driver includes a handle having ergonomic recesses. A manual driver includes a shank and a handle attached to the shank. The handle includes a proximal portion, a middle portion, and a distal portion. The distal portion has a distal portion distal end cross section that includes polygonal perimeter line segments joined by intervening perimeter segments. The distal portion has a distal portion proximal end cross section that includes polygonal perimeter line segments joined by intervening perimeter segments. Orientations of the polygonal perimeter line segments of the distal portion distal end are offset rotationally by 15 degrees to 45 degrees around the shank axis relative to the polygonal perimeter line segments of the distal portion proximal end. The distal portion comprises distal portion recesses, which extend from the distal portion proximal end to the distal portion distal end.