Abstract: The topological analysis of chiral molecular models led to the development of a general procedure for specifying chirality. The application of this procedure to organic chemical configurations, as described earlier (1956 and before), is retained in this paper, but modified and redefined with regard to certain structure types. These changes are largely based on experience gained at the Beilstein Institute and elsewhere since 1956. The procedure is now extended to allow the treatment of both organic chemical conformations and inorganic chemical configurations up to six ligand atoms. The paper discusses the issues that arise when transferring the symbols obtained from the model's chirality specification to the nomenclature, paying particular attention to the combination of chirality symbols obtained from the general procedure with those obtained from special procedures and with trivial nomenclature systems.

Abstract: Provided herein are methods of treating a skin-related disease or disorder (such as melasma). Also provided are pharmaceutical compositions of midostaurin or a pharmaceutically acceptable salt thereof formulated for topical administration. Further described are methods for preparing such topical pharmaceutical compositions and methods of using the same for treating a subject.

Abstract: Provided are pharmaceutical compositions which include an active pharmaceutical ingredient having a calculated log P in octanol-water equal or greater than about 4.0, at least one solubilizer, and optionally at least one stratum corneum penetration enhancer, wherein the pharmaceutical composition can be formulated for topical administration. In some instances, the active pharmaceutical ingredient is clofazimine.

Abstract: Various substituted benzoxazoles and benzothiazoles, are described and disclosed, which are potent inhibitors of leukotriene synthesis in warm-blooded animals.

Abstract: Various substituted benzoxazoles, benzothiazoles, oxazolopyridines and thiazolopyridines are described and disclosed, compounds that are potent inhibitors of leukotriene synthesis in warm-blooded animals.