Patents by Inventor Peter Fecci

Peter Fecci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • D2C7 EGFR AND EGFR VIII BI-SPECIFIC CHIMERIC ANTIGEN RECEPTOR CONSTRUCTS AND METHODS OF MAKING AND USING SAME
    Publication number: 20240293546
    Abstract: The present disclosure provides, in part, a novel chimeric antigen receptor (CAR) T cell that will simultaneously target wildtype EGFR (EGFRwt) and the vIII variant (EGFRvIII) and methods of making and using same.
    Type: Application
    Filed: July 1, 2022
    Publication date: September 5, 2024
    Inventors: Peter FECCI, Darell BIGNER, Daniel LANDI, Daniel WILKINSON, Katherine RYAN
  • CHIMERIC APOPTOTIC SIGNAL TARGETING LYMPHOCYTES (TIM-4 CASTL) AND METHODS OF MAKING AND USING SAME
    Publication number: 20240182540
    Abstract: The present invention provides recombinant TIM-4 fusion proteins comprising an extracellular domain of TIM-4 and at least one co-stimulatory domain. Also provided are cells comprising the fusion protein and methods of making and using the same.
    Type: Application
    Filed: November 16, 2023
    Publication date: June 6, 2024
    Inventors: Peter Fecci, Daniel Wilkinson, Ethan Srinivasan
  • RECOMBINANT TIM-4 PROTEIN, CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL DELIVERY SYSTEM AND METHODS OF MAKING AND USING SAME
    Publication number: 20240156868
    Abstract: The present invention provides recombinant TIM-4 fusion proteins comprising a domain of TIM-4 and a scFv specific for CD3 and methods of making and using the same. The fusion proteins provided herein may be administered in combination with CAR T cells. In addition CAR T cells engineered to express the TIM-4 fusion proteins described herein are also provided and may be used in the methods described herein.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 16, 2024
    Inventors: Peter Fecci, Daniel Wilkinson
  • Compositions and Methods for the Treatment of Intracranial Diseases
    Publication number: 20220257583
    Abstract: Provided herein are compositions and methods for enhancing egress of T-cells from bone marrow of a subject in need thereof. Also provided are compositions and methods for the treatment of diseases characterized by reduced surface display of sphingosine-1-phosphate receptor 1 (S1P1), as well as methods of diagnosis/prognosis related to surface display of SIP 1. Methods of treating cancer are also provided.
    Type: Application
    Filed: July 31, 2020
    Publication date: August 18, 2022
    Inventors: Peter Fecci, Pakawat Chongsathidkiet, Alem Kahsai, Robert Lefkowitz