Abstract: A method of selectively heating a lesion or tumor using laser therapy treatment includes administering plasmonic metal nanoplatforms to a subject having the lesion or tumor and administering laser therapy treatment to the lesion or tumor. The plasmonic metal nanoplatforms selectively accumulate in the lesion or tumor and the laser therapy is strongly absorbed by the plasmonic metal nanoplatforms that are accumulated in the lesion or tumor. The plasmonic metal nanoplatforms fill the contours of the lesion or tumor thereby enabling laser treatment in a conformal way. The plasmonic metal nanoplatforms selectively accumulate in the lesion or tumor produce efficient photon-to-heat conversion, thus transforming them into heat sources, leading to efficient heat transport, thereby inducing a larger treatment area.

Abstract: The present disclosure provides, in part, a novel chimeric antigen receptor (CAR) T cell that will simultaneously target wildtype EGFR (EGFRwt) and the vIII variant (EGFRvIII) and methods of making and using same.

Abstract: The present invention provides recombinant TIM-4 fusion proteins comprising an extracellular domain of TIM-4 and at least one co-stimulatory domain. Also provided are cells comprising the fusion protein and methods of making and using the same.

Abstract: The present invention provides recombinant TIM-4 fusion proteins comprising a domain of TIM-4 and a scFv specific for CD3 and methods of making and using the same. The fusion proteins provided herein may be administered in combination with CAR T cells. In addition CAR T cells engineered to express the TIM-4 fusion proteins described herein are also provided and may be used in the methods described herein.

Abstract: Provided herein are compositions and methods for enhancing egress of T-cells from bone marrow of a subject in need thereof. Also provided are compositions and methods for the treatment of diseases characterized by reduced surface display of sphingosine-1-phosphate receptor 1 (S1P1), as well as methods of diagnosis/prognosis related to surface display of SIP 1. Methods of treating cancer are also provided.