Patents by Inventor Peter Fekkes

Peter Fekkes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods to increase production
    Patent number: 11897918
    Abstract: Disclosed herein are methods for increasing protein yield and cellular productivity. Chemical agents facilitate host cell production of biological molecules to increase product yield.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: February 13, 2024
    Assignee: Seqirus UK Limited
    Inventors: Samuel Ho, David Parker, Peter Fekkes, Ivna De Souza, Peter Mason, Pirada Allen
  • Splice variants associated with neomorphic SF3B1 mutants
    Patent number: 11761045
    Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: September 19, 2023
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Lihua Yu, Kian Huat Lim, Jacob D. Feala, Silvia Buonamici, Yoshiharu Mizui, Peter G. Smith, Ping Zhu, Eunice Sun Park, Michael W. Seiler, Marco Peter Fekkes
  • TECHNOLOGIES USEFUL FOR ASSESSING PERMEABILITY
    Publication number: 20230046728
    Abstract: In some embodiments, the invention relates to methods and reagents for the identification of compounds that traverse he cell membrane of an animal cell. In some embodiments, the invention provides additional methods for determining if a candidate compound that traverses an animal cell membrane is able to modulate an intracellular target, as well as reagents and kits for reagents and kits for performing the disclosed methods.
    Type: Application
    Filed: December 11, 2020
    Publication date: February 16, 2023
    Inventors: Amrita Singh Chandhoke, James Andrew Madsen, Yue-Mei Zhang, John Hanney McGee, Marco Peter Fekkes
  • Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2 inhibitors, BCL2/BCLxL inhibitors, and BCLxL inhibitors and methods of use
    Patent number: 11524009
    Abstract: The present disclosure provides pharmaceutical combinations comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors. Also provided are methods of treating cancer comprising administering a therapeutically effective amount of at least one spliceosome modulator and a therapeutically effective amount of at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: December 13, 2022
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Daniel Aird, Laura Corson, Ping Zhu, Markus Warmuth, Silvia Buonamici, Peter Gerard Smith, Peter Fekkes
  • SPLICE VARIANTS ASSOCIATED WITH NEOMORPHIC SF3B1 MUTANTS
    Publication number: 20210130909
    Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.
    Type: Application
    Filed: November 16, 2020
    Publication date: May 6, 2021
    Inventors: Lihua Yu, Kian Huat Lim, Jacob D. Feala, Silvia Buonamici, Yoshiharu Mizui, Peter G. Smith, Ping Zhu, Eunice Sun Park, Michael W. Seiler, Marco Peter Fekkes
  • Splice variants associated with neomorphic SF3B1 mutants
    Patent number: 10889866
    Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: January 12, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Lihua Yu, Kian Huat Lim, Jacob D. Feala, Silvia Buonamici, Yoshiharu Mizui, Peter G. Smith, Ping Zhu, Eunice Sun Park, Michael W. Seiler, Marco Peter Fekkes
  • COMBINATION COMPRISING AT LEAST ONE SPLICEOSOME MODULATOR AND AT LEAST ONE INHIBITOR CHOSEN FROM BCL2 INHIBITORS, BCL2/BCLXL INHIBITORS, AND BCLXL INHIBITORS AND METHODS OF USE
    Publication number: 20200352937
    Abstract: The present disclosure provides pharmaceutical combinations comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors. Also provided are methods of treating cancer comprising administering a therapeutically effective amount of at least one spliceosome modulator and a therapeutically effective amount of at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors.
    Type: Application
    Filed: October 30, 2018
    Publication date: November 12, 2020
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Daniel AIRD, Laura CORSON, Ping ZHU, Markus WARMUTH, Silvia BUONAMICI, Peter Gerard SMITH, Peter FEKKES
  • COMPOSITIONS AND METHODS TO INCREASE PRODUCTION
    Publication number: 20200040040
    Abstract: Disclosed herein are methods for increasing protein yield and cellular productivity. Chemical agents facilitate host cell production of biological molecules to increase product yield.
    Type: Application
    Filed: March 11, 2019
    Publication date: February 6, 2020
    Inventors: Samuel Ho, David Parker, Peter Fekkes, Ivna De Souza, Peter Mason, Pirada Suphaphiphat
  • SPLICE VARIANTS ASSOCIATED WITH NEOMORPHIC SF3B1 MUTANTS
    Publication number: 20180318312
    Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.
    Type: Application
    Filed: August 30, 2016
    Publication date: November 8, 2018
    Inventors: Lihua Yu, Kian Huat Lim, Jacob D. Feala, Silvia Buonamici, Yoshiharu Mizui, Peter G. Smith, Ping Zhu, Eunice Sun Park, Michael W. Seiler, Marco Peter Fekkes
  • COMPOSITIONS AND METHODS TO INCREASE PRODUCTION
    Publication number: 20170044216
    Abstract: Disclosed herein are methods for increasing protein yield and cellular productivity. Chemical agents facilitate host cell production of biological molecules to increase product yield.
    Type: Application
    Filed: April 20, 2015
    Publication date: February 16, 2017
    Inventors: Samuel HO, David PARKER, Peter FEKKES, Ivna DE SOUZA, Peter MASON, Pirada SUPHAPHIPHAT
  • Polypeptides interactive with Bcl-XL
    Publication number: 20030032157
    Abstract: Described herein are methods and reagents for identifying polypeptides that bind to a Bcl-XL polypeptide, and methods for identifying compounds that modulate the interaction between a Bcl-XL-binding polypeptide and a Bcl-XL polypeptide.
    Type: Application
    Filed: March 7, 2002
    Publication date: February 13, 2003
    Inventors: Philip W. Hammond, Martin C. Wright, Julia Alpin, Peter Fekkes