Abstract: This invention relates to disinfectant compositions comprising a first active ingredient comprising a source of acetyl radicals, and a second active ingredient comprising a source of peroxygen, the composition being soluble in water to provide a solution of peracetic acid.

Abstract: The invention relates to the use of compounds of formula (I) in the treatment of mammalian target of rapamycin (mTOR) kinase dependent diseases, methods of use of said compounds in the treatment of said diseases in a warm-blooded animal, especially a human, pharmaceutical preparations comprising said compounds for the treatment of said diseases and said compounds for use in the treatment of said diseases.

Abstract: This invention relates to disinfectant compositions comprising a first active ingredient comprising a source of acetyl radicals, and a second active ingredient comprising a source of peroxygen, the composition being soluble in water to provide a solution of peracetic acid.

Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: The present invention relates to a sanitising composition, particularly to a sanitising composition for combating undesired microorganisms, especially those present on food products such as salads, poultry, cut fruit, and in hospital environments. There is provided a sanitising composition comprising at least one flavonoid, and at least one a surfactant, wherein the composition is acidic.

Abstract: A preservative composition held under acidic conditions comprises at least one flavonoid and at least one antimicrobial auxiliary. It is useful as a constituent of a product to be preserved, such as a shampoo, hair conditioner, skin lotion, baby bath wash, moisturiser, medicinal cream, cosmetic product, laundry formulation, paint, oral care product or food preparation.

Abstract: The invention relates to the use of compounds of formula (I) in the treatment of mammalian target of rapamycin (mTOR) kinase dependent diseases, methods of use of said compounds in the treatment of said diseases in a warm-blooded animal, especially a human, pharmaceutical preparations comprising said compounds for the treatment of said diseases and said compounds for use in the treatment of said diseases.

Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: The present invention relates to the use of antagonists of the mTOR signaling pathway and its constituent members (e.g., antagonists of MAPKAP) for the treatment, amelioration, and diagnosis of PI3K/AKT/mTOR-related disorders, e.g., cancers. The present invention also relates to methods of using modulators of mTOR (e.g., modulators of MAPKAP) for the treatment, amelioration, and diagnosis of PI3K/AKT/mTOR-related disorders, e.g., cancers. Assays for the identification of modulators of mTOR, MAPKAP, and hVPS34 are also provided.

Abstract: The present invention relates to novel uses and reagents relating to apoptosis-related disorders. In particular, modulation of PI3K class II? activity is shown to influence apoptosis, and PI3K class II? is thought to be cellular survival factors. Based on these findings the present invention provides therapeutic methods and pharmaceutical compositions useful for the treatment of apoptosis-related disorders. In addition, PI3K class II? is provided as a target for the development of therapeutics. Accordingly, the invention provides screening methods for identifying candidate compounds that modulate PI3K class II? activity and may therefore be used to treat apoptosis-related disorders such as cardiovascular disorders, autoimmune disorders, neurodegenerative disorders, and cancer.

Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: On a known peat harvesting apparatus for mounting on an agricultural tractor comprising (a) a digging chain for insertion into and movement across a bog so as to form a groove, and (b) a peat extrusion press, a roller (107) is mounted above the digging chain (104) to direct harvested peat into the press and prevent the apparatus from clogging. A single drive transmission connects both digging chain (104) and extrusion press (105) to the tractor power take-off shaft. A macerating mechanism is provided in the extrusion press (105) which allows extrusions of relatively small cross section to be produced.