Patents by Inventor Peter Fitzgerald
Peter Fitzgerald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12250875Abstract: Provided are compounds comprising a ligand LA of Formula I where the ligand LA is coordinated to Ir.Type: GrantFiled: November 8, 2023Date of Patent: March 11, 2025Assignee: UNIVERSAL DISPLAY CORPORATIONInventors: Hsiao-Fan Chen, George Fitzgerald, Tyler Fleetham, Peter Wolohan, Joseph A. Macor, Morgan C. Macinnis, Wystan Neil Palmer, Geza Szigethy, Noah Horwitz
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Patent number: 12246323Abstract: An assay cartridge for use in a molecular diagnostics assay having an assay region; a first end comprising a first engagement member for engaging with a support housing; and a second end comprising a second engagement member for engaging with a support housing. The second engagement member has a clip, the clip being formed by a resilient element extending from the second end of the cartridge and a fastening element extending from said resilient element. The clip has a release element extending from the resilient element actuatable to release the clip from a caddy in use.Type: GrantFiled: April 9, 2020Date of Patent: March 11, 2025Assignee: RANDOX LABORATORIES LTDInventors: Marc Wharry, Martin Reid, Peter Fitzgerald
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Publication number: 20250044313Abstract: An apparatus for assaying one or more lateral flow test devices. The apparatus comprises at least one support device for supporting one or more lateral flow test devices in use and at least one sample receptacle configured to receive, in use, a respective liquid sample to be dispensed onto a corresponding lateral flow test device. The apparatus further comprises a dispensing apparatus configured to dispense a known volume of the received liquid sample from the sample receptacle onto the corresponding lateral flow test device supported by the support device.Type: ApplicationFiled: December 9, 2022Publication date: February 6, 2025Applicant: RANDOX LABORATORIES LTD.Inventors: Ivan MCCONNELL, Lewis MCKINSTRY, Peter FITZGERALD
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Patent number: 12214102Abstract: There is provided a sterilisation monitoring device for a molecular diagnostics analyser. The device comprises a sensor arranged in use to detect radiation; and an analysis unit connected to the sensor. The analysis unit is arranged in use to issue a signal when the radiation level incident on the sensor is lower than a threshold level.Type: GrantFiled: April 9, 2020Date of Patent: February 4, 2025Assignee: RANDOX LABORATORIES LTDInventors: Catherine McCooke, Peter Fitzgerald
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Patent number: 12208397Abstract: There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.Type: GrantFiled: August 2, 2019Date of Patent: January 28, 2025Assignee: RANDOX LABORATORIES LTDInventors: Paul Courtney, Martin Reid, Stuart Jackson, John Lamont, Ivan McConnell, Peter Fitzgerald
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Patent number: 12208526Abstract: Pick quality determination is disclosed, including: using a pressure meter to sense a pressure associated with an airflow through a gripper mechanism of a diverting mechanism over time during a pick operation on a target object; storing the sensed pressure associated with the airflow through the gripper mechanism over time as a pressure sequence associated with the pick operation on the target object; and correlating the pressure sequence with representative pressure sequences associated with corresponding pick quality types to determine whether the pick operation on the target object was successful or not.Type: GrantFiled: August 11, 2023Date of Patent: January 28, 2025Assignee: AMP Robotics CorporationInventors: Matthew Stanton, Jacob Fitzgerald, Jeffrey Stenberg, Jason M. Calaiaro, Carter J. Schultz, John C. McCoy, Jr., Kevin Taylor, Brian J. Leach, Peter March, Joseph M. Castagneri, Brendan Edward Richards
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Publication number: 20250003987Abstract: A method is described for the identification of individuals with a BMI of less than 25 who have a biochemical profile that corresponds to an overweight or obese phenotype. The method of highlighting this hidden obesity makes use of various biomarker combinations that can incorporate various analytes including leptin and complement C3.Type: ApplicationFiled: November 8, 2022Publication date: January 2, 2025Inventors: Paul Innocenzi, Stephen Peter Fitzgerald, Ivan McConnell
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Publication number: 20240402176Abstract: Haematuria is a considerable burden within primary and secondary care; too many haematuria patients are referred to secondary care for invasive and expensive investigations that could be managed in primary care. The current invention has identified biomarker combinations with utility for the diagnosis of bladder cancer in males. Using gender specific biomarker algorithms in combination with clinical risks that are associated with bladder cancer, would allow clinicians to better manage haematuria patients in primary care setting.Type: ApplicationFiled: September 29, 2022Publication date: December 5, 2024Inventors: Stephen Peter Fitzgerald, Mark Ruddock, John Lamont
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Publication number: 20240345092Abstract: Single markers lack both sensitivity and specificity to stratify risk of PCa in patients who present with elevated tPSA and abnormal DRE. The novel combination of serum markers identified in this study could be employed to help triage patients into ‘low’ and ‘high’ risk categories, allowing general practitioners (GPs) to improve management of patients in primary care settings and potentially reducing the number of referrals for unnecessary, invasive, and costly treatments.Type: ApplicationFiled: August 10, 2022Publication date: October 17, 2024Inventors: Stephen Peter Fitzgerald, Mark Ruddock, John Lamont, Declan McKenna
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Publication number: 20240310400Abstract: There is provided an apparatus and method for extracting a biological sample from a sample container. The apparatus comprising: a holder arranged in use to support a sample container; an extractor moveable in use between a first position disengaged from the container when the container is supported by the holder and a second position engaged with the container when the container is supported by the holder, the extractor being arranged in use to obtain matter from the container when in the second position; and an imager arranged in use to capture an image of the extractor at the first position when the extractor is moved from the second position to the first position and to identify, based on analysis of the captured image, when sample is present outside the container.Type: ApplicationFiled: July 8, 2022Publication date: September 19, 2024Applicant: RANDOX LABORATORIES LTD.Inventors: James DAVIDSON, Ivan MCCONNELL, Peter FITZGERALD
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Publication number: 20240296539Abstract: There is provided a vision system for assessing defects on biochips and a corresponding method. The vision system comprises an imaging region in which a biochip sheet including at least one biochip is locatable in use: an imager arranged in use to image at least a portion of the imaging region, wherein, when the biochip sheet is located in the imaging region. the portion includes at least a face of the biochip sheet: and an illumination source arranged in use to direct illumination on to the face the biochip sheet. thereby illuminating defects on the at least one biochip when a mask material layer is present on the at least one biochip and when a mask material is absent and allowing the defects to be included in the imaged at least a portion of the imaging region.Type: ApplicationFiled: July 1, 2022Publication date: September 5, 2024Applicant: Randox Laboratories Ltd.Inventors: Deepesh UPADHYAY, Peter FITZGERALD, Ivan MCCONNELL
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Publication number: 20240201178Abstract: The present invention relates to improved detection assays via the utilisation of a substrate with an analyte immobilised on its surface by means of a linking agent and a cross-linker. The present invention also relates to a method of producing a substrate for use in detection assays and a method of detecting an analyte using said substrate.Type: ApplicationFiled: March 31, 2022Publication date: June 20, 2024Inventors: Peter Fitzgerald, John Victor Lamont, Ivan McConnell, Ciaran Richardson, Philip Lowry, Jim Curry
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Publication number: 20240168038Abstract: The current invention provides methods which can be implemented alongside clinical variables as risk prediction tools for improved prediction of CKD progression and mortality. Surprisingly it was found that decreased C3a-desArg was associated with adverse outcome in CKD, and when combined with increased STNFR1 and NGAL it gave an excellent predictor of progression to a composite endpoint in CKD patients.Type: ApplicationFiled: March 25, 2022Publication date: May 23, 2024Inventors: Ivan McConnell, Peter Fitzgerald, John Lamont, Ciaran Richarson, Matthew Griffin
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Publication number: 20240124935Abstract: Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed.Type: ApplicationFiled: December 27, 2023Publication date: April 18, 2024Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Yong-Chen Lu, Peter Fitzgerald, Zhili Zheng, Steven A. Rosenberg
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Publication number: 20240091783Abstract: There is provided a bracket for a biological sample analyser. The bracket comprises abase and an arm extending from the base, the base being engageable with a platform of a biological sample analyser, wherein, when the base is engaged with the platform, the arm extends into a sample plate bay of the biological sample analyser prohibiting access to a portion of the bay. The arm thereby limits misalignment of a sample plate in the bay by blocking access to a portion of the bay only required when the sample plate is loaded into the bay in an incorrect orientation. A biological sample analyser comprising a bay in which a sample plate is loadable in use and the bracket is also provided.Type: ApplicationFiled: January 21, 2022Publication date: March 21, 2024Inventors: Dale Love, Peter Fitzgerald, Ivan McConnell, Christina McFadden
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Patent number: 11898207Abstract: Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed.Type: GrantFiled: March 28, 2018Date of Patent: February 13, 2024Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Yong-Chen Lu, Peter Fitzgerald, Zhili Zheng, Steven A. Rosenberg
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Publication number: 20240003910Abstract: Methods and products for adjusting the chronological age of a biological system or an individual to provide finer scale insight to health status are provided. The methods are underpinned by various serum and urinary biomarkers including antistreptolysin.Type: ApplicationFiled: November 15, 2021Publication date: January 4, 2024Inventors: Paul Innocenzi, Peter Fitzgerald, McMaster Steven
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Publication number: 20230406933Abstract: The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.Type: ApplicationFiled: November 2, 2021Publication date: December 21, 2023Inventors: Marshall Dunlop, Shirley Schon, John Lamont, Peter Fitzgerald
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Patent number: 11602757Abstract: There is provided a method of extracting material from a fluid method of extracting material from a fluid, the fluid being held within a fluid chamber. The method comprises drawing, with a magnetic field generating system, at least one magnetically susceptible member through the fluid around a closed path between at least three points in the chamber, said at least one member being adapted to bind to material in fluid in the chamber. The at least three points are arranged relative to each other in a shape having at least two dimensions, the magnetic field generating system being configured to move the at least on magnetically susceptible member directly between the at least three points, material in the fluid binding to the at least one magnetically susceptible member when it comes into contact with the at least one member as it moves through the fluid.Type: GrantFiled: October 13, 2017Date of Patent: March 14, 2023Assignee: RANDOX LABORATORIES LTD.Inventors: Stuart Jackson, Stephen Peter Fitzgerald, Ivan McConnell, John Lamont
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Patent number: 11554945Abstract: A beverage dispenser for dispensing beverage from one or more beverage units. Each of the beverage units includes a respective beverage unit outlet, and a respective support structure supporting beverage and orienting the respective beverage unit outlet. The dispenser includes a refrigerator in which the beverage unit(s) are receivable; a respective inlet, within the refrigerator, for each of the beverage units; at least one a dispensing outlet for dispensing beverage into drinking vessels; one or more fluid paths from the inlet(s) to the dispensing outlet(s); a guide arrangement co-operable with the support structure(s) to guide the beverage unit(s) so that each respective beverage unit outlet co-operates with its respective inlet to form a respective dry break connection through which beverage is conveyable on route to the dispensing outlet(s) via the fluid path(s).Type: GrantFiled: December 24, 2020Date of Patent: January 17, 2023Assignee: DE BORTOLI WINES PTY LIMITEDInventors: Peter Fitzgerald, Peter Thatcher, Paul Morrice