Abstract: The invention describes accurate and flexible methods and kits for conducting multi-analyte microarrays through the use of Tag-specific antibodies and analyte-specific Tag-anchored antibodies.

Abstract: The invention relates to an immunoassay method and kit for the indirect detection of chloral hydrate. The invention is underpinned by a novel immunogen that produces an antibody that is specific for the chloral hydrate metabolite trichloroethanol glucuronide. Detection and quantification of trichloroethanol glucuronide has important applications in clinical toxicology, drug facilitated crime, water testing and solvent exposure.

Abstract: A biochip well is disclosed, including a vessel containing a well therewithin, the vessel forming at least base and side walls of the well and defining at least one aperture giving access to the well, and further including retaining means for holding a biochip at a predetermined position within the well, the well including a laterally offset region into which the biochip does not protrude when held at the predetermined position by the retaining means. Also disclosed are sealed well assemblies and apparatus and methods for opening sealed wells.

Abstract: The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and RCS families. Unique antibodies derived from novel immunogens enable said methods and kits.

Abstract: The invention describes a practical and robust multi-antibody approach to the sensitive immunodetection and determination of the drug of abuse m-chlorophenyl piperazine (mCPP). The invention also describes methods and kits for mCPP detection in an in vitro sample.

Abstract: A valve for a reagent bottle is provided, the valve including a resilient membrane configured to extend across an opening in the reagent bottle, the resilient membrane having at least one slit extending therethrough. Also disclosed is a dispensing apparatus for dispensing a reagent from a reagent bottle, the dispensing apparatus comprising: a probe assembly having a probe adapted for insertion into the reagent bottle through the valve and an extraction mechanism for drawing reagent out of the reagent bottle through the probe. A valve opening assembly is provided, which is adapted to open the valve of the reagent bottle such that the probe can pass through the valve without contacting the valve.

Abstract: The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the CP family. Unique antibodies derived from novel immunogens enable said methods and kits.

Abstract: Assay device processing apparatus includes a rotatably mounted assay device vessel support; and a drive for rotating the support. The support is rotatable about a substantially horizontal first axis so that, upon rotation, an assay device vessel attached to the support can be inverted.

Abstract: An assembly for monitoring load on a drum during an operation in a well with a well access line deployed from the drum. The assembly may include multiple line detection mechanisms for acquiring real-time information relative to dynamic characteristics of the lone over the course of the operation. The assembly also includes a processor for computing the real-time information in light of pre-stored information relative to physical characteristics of the line and the drum. As a result, real-time monitoring of a load on the drum may be achieved. Thus, the operation may be adjusted in real-time as necessary to avoid over- loading of the drum. Additionally, a drum load history may be recorded so as to better account for the true condition of the drum following successive operations.

Abstract: The invention relates to novel immunogens, antibodies, methods and kits for use in immunoassays to detect and quantify zaleplon, metabolites of zaleplon and indiplon. These are the first described immunoassays for these compounds and have greater sensitivity than alternative analytical techniques.

Abstract: The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and CP families. Unique antibodies derived from novel immunogens enable said methods and kits.

Abstract: A bicycle-mountable hydration system includes a first and a second bladder, each-configured to hold liquid, and a holder configured to be supported by a top bar of a bicycle. The holder has first and second outward-facing sides and first and second inward-facing sides. The holder includes a left portion that is configured to receive the first bladder at the first-inward-facing side and a right portion that is configured to receive the second bladder at the second inward-facing side and a middle portion connecting the left portion and the right portion. When the holder is supported by a top bar of a bicycle, the first-inward-facing side of the left portion faces the first-inward-facing side of the right portion. The middle portion may hang over the top bar of the bicycle to support the holder with the first bladder on an opposite side of the top bar from the second bladder. The system may be convertible to function as a hydration backpack when removed from the bicycle.

Abstract: The invention describes a method for monitoring and detecting non-therapeutic, therapeutic and toxic concentrations of aspirin in individuals which uses the urinary salicylic acid to salicyluric acid ratio.

Abstract: The invention describes a practical and robust multi-antibody approach to the sensitive immunodetection and determination of the drug of abuse m-chlorophenyl piperazine (mCPP). The invention also describes methods and kits for mCPP detection in an in vitro sample.

Abstract: The invention relates to an immunoassay method and kit for the detection and/or the determination of mephedrone, mephedrone metabolites and related compounds. The invention is underpinned by a novel antibody, derived from a novel immunogen, that is sensitive and binds to mephedrone, mephedrone metabolites and related compounds.

Abstract: Systems and methods for treating internal tissue defects, such as septal defects, with clip-based devices are provided. An exemplary clip-based device includes a tubular body having at least a first and a second deflectable member coupled thereto. The first and second members are coupled on opposite ends of the tubular body and configured to deflect between an undeployed configuration and a deployed configuration. In the deployed configuration, each member extends outwardly away from the tubular body in a position configured to abut a tissue surface. The first and second members are preferably configured to maintain a tissue wall therebetween and at least partially close any opening in the tissue wall.

Abstract: Carisoprodol is a centrally-acting prescription drug of known abuse. Upon ingestion it is rapidly metabolised to meprobamate, also a prescription drug with abuse potential. Current immunoassays are specific for carisoprodol and therefore have a short window of detection and, furthermore, are ineffective at detecting meprobamate. The current invention, underpinned by an antibody specific for meprobamate, overcomes these deficiencies.

Abstract: The invention relates to an immunoassay method and kit for the indirect detection of chloral hydrate. The invention is underpinned by a novel immunogen that produces an antibody that is specific for the chloral hydrate metabolite trichloroethanol glucuronide. Detection and quantification of trichloroethanol glucuronide has important applications in clinical toxicology, drug facilitated crime, water testing and solvent exposure.

Abstract: Production logging apparatus and method are provided. The apparatus comprises a coupling module, an electronic module, a micro-winch, a docking station, and a micro-production logging tool. The coupling module provides mechanical support for the production logging apparatus below a pumping arrangement disposed in a wellbore, and allows flow to enter the pumping arrangement. The electronic module comprises a winch controller, a powering module and a telemetry module, and adapted to automate the micro-winch. The docking station comprises a latching mechanism for ensuring positive engagement of a micro-production logging tool with the production logging apparatus during docking. And the micro-production logging tool comprises at least one sensor and is coupled to the micro-winch by a cable for regular production logging runs to measure the evolution of well characteristics.

Abstract: The present disclosure relates to one or more methods and apparatus to dispose one or more markers within a subterranean formation. The method includes positioning a drill probe assembly in a borehole extending into the subterranean formation, drilling a hole through a sidewall of the borehole with a flexible shaft of the drill probe assembly, the hole penetrating the subterranean formation, and disposing a marker in the hole.