Abstract: A locking mechanism for a slide out tray system may have a cam that is connected to a lock rod. A lock bar lever may be rotatable about an offset portion, such that when the cam is rotated, the end of the lock bar lever in contact with the cam is pushed upwards, thus pushing the opposite end of the lock bar lever downwards to push the locking plate down, allowing the slide out tray system to slide into a closed position. A bushing lock may interact with lock rod flanges. The lock rod flanges roll over and are supported by a bushing. When the bushing meets a space between the lock rod flanges, the lock rod may automatically rotate such that the flange contacts an edge of the bushing lock, thus preventing the lock rod and tray system from extending any further.

Abstract: A syringe manifold for a fluid injector assembly includes a middle body member defining an upper cavity and a lower cavity, the middle body member defining at least one fluid path in an upper surface of the middle body member and at least one fluid path in a lower surface of the middle body member, the middle body member defining at least two ports extending through the middle body member, the middle body member comprising an outlet for connection of the syringe manifold to at least one fluid delivery device; a lower body member received within the lower cavity of the middle body member, the lower body member comprising at least one connector for connection of the lower body member to a syringe assembly; and an upper body member received within the upper cavity of the middle body member.

Abstract: Light projection systems using white light illumination. One embodiment provides a projection system using white light illumination. The projection system includes an illumination assembly configured to receive a white light input. A prism is configured to separate the white light input into color light inputs, redirect the color light inputs to respective modulators, and combine modulated color light inputs from the respective modulators into a white light output. An optical filter is configured to spatially Fourier transform the white light output to generate a filtered white light output. A projection lens assembly is configured to project the filtered white light output.

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding human REP1, vectors, and host cells comprising codon optimized REP1 sequences, and methods of treating retinal disorders such as choroideremia comprising administering to the subject a codon optimized sequence encoding human REP1.

Abstract: Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and in clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more cells of the retina, for the treatment of retinal disorders and diseases.

Abstract: The present invention relates to a method of improving the efficacy of treatment of line 2+ metastatic castration-resistant prostate cancer (mCRPC) with biallelic DNA-repair anomalies in a male human, wherein said biallelic DNA-repair anomalies are selected from: i) BRCA (BRCA1, BRCA2, or a combination thereof), ii) non-BRCA (ATM, FANCA, PALB2, CHEK2, BRIP1, HDAC2, or any combination thereof): or iii) any combination thereof; wherein the male human has received prior taxane-based chemotherapy and androgen receptor (AR)-targeted therapy; said method of improving the efficacy of treatment comprising administering to said male human a once-daily oral dosing of 300 mg niraparib.

Abstract: This disclosure provides an oxygen delivery and reclamation system that supplies breathable oxygen-enriched gas to one or more users in a chamber. The one or more users receive oxygen at specified oxygen level setpoints. Exhalation air from the one or more users may be purged from the breathing loop using one or both of a recycle pump and an electronically actuated valve. Exhalation air in a purge line and optionally chamber air pulled from the chamber may be recycled using an oxygen concentrator. The oxygen concentrator generates oxygen-enriched gas and oxygen-depleted gas, where the oxygen-enriched gas may be delivered back to one or more users in the chamber.

Abstract: An integrated pressurized pump shaft seal assembly for a submersible rotary fluid pump comprises an oil reservoir having a pressure equal to or less than the ambient pressure external fluids surrounding the casing, the oil reservoir feeding an oil pump impeller that is mountable onto, so as to be rotated by, the rotary fluid pump shaft. The oil pump impeller is in fluid communication with an internal volute diffusion element integrated into a pump component. The centrifugal oil pump impeller pumps oil from the oil reservoir to the seal chamber through the internal volute diffusion element so as to increase a pressure within the seal chamber to a positive pressure above the ambient pressure of the external fluids surrounding the pump housing.

Abstract: Systems and methods are provided for managing orders and aggregating market data across a plurality of liquidity sources via an order router and market aggregator that is tightly integrated with a matching engine for substantially synchronous activity.

Abstract: A thermoset material containing ?-hydroxyesters wherein said thermoset material is subject to a mechano-chemical process to regenerate an epoxide and a carboxylic acid functionality. A curative for epoxidized plant-based oils and epoxidized natural rubber is created from the reaction between a naturally occurring polyfunctional acid and an epoxidized plant-based oil is disclosed. The curative may be used to produce porosity-free castable resins and vulcanize rubber formulations based on epoxidized natural rubber. Materials made from disclosed materials may be advantageously used as leather substitutes.

Abstract: A data modeling and analytics platform augments and annotates content captured from a user's online interactions and other documents. The data modeling and analytics platform is performed within a machine learning and artificial intelligence-based processing environment that enables observability, explainability, and data analytics for dynamic information discovery over time within a user library that includes files representing the online interactions and documents containing information of user interest.

Abstract: In some examples, a method includes bonding a multilayered filter medium comprised of at least one layer of filter membrane and at least one support layer web material by bonding along a perimeter of the filter web while concurrently slitting the multilayered filter medium. Further, some examples include a filter element comprising a multilayered filter medium with at least one first layer of a filter membrane or a meltblown material, and at least one support layer web material as a second layer, wherein the at least one first layer and the at least one second layer are bonded and sealed to each other along a perimeter thereof.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant A.AV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: Compositions for reducing methane emission and/or inhibiting one or more methanogens are provided. The compositions comprise an organohalogen compound and an organo sulfur compound, preferably bromoform and allicin. The compositions may further comprise a polyphenol compound. An animal feed comprising the composition is also described.

Abstract: A tip for a surgical instrument comprising a cradle that is moveably mounted to a distal end of an elongate shaft. The cradle is rotatable relative to the elongate shaft about a pitch axis. A member is pivotally coupled to the cradle to move with and relative to the cradle about a grip axis that is substantially orthogonal to the pitch axis. The member is movable relative to the cradle about a yaw axis. In some embodiments, there is a second member that is pivotally coupled to the cradle to move with and relative to the cradle about a second grip axis that is substantially orthogonal to the pitch axis. In some embodiments, the first member and second member are selectably movable relative to each other between a closed configuration in which the first member contacts the second member and an open configuration.

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding hum n alpha-galactosidase A, vectors, and host cells comprising codon optimized alpha-galactosidase A sequences, and methods of treating disorders such as Fabry disease comprising administering to the subject a codon optimized sequence encoding human alpha-galactosidase A.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding human alpha-galactosidase A, vectors, and host cells comprising codon optimized alpha-galactosidase A sequences, and methods of treating disorders such as Fabry disease comprising administering to the subject a codon optimized sequence encoding human alpha-galactosidase A.

Abstract: The present disclosure provides codon optimized RPGRorf15 sequences, vectors, and host cells comprising codon optimized RPGRorf15 sequences, and methods of treating retinal disorders such as XLRP comprising administering to the subject a codon optimized RPGRorf15 sequence.

Abstract: An electric winding assembly comprising a conductor core which includes at least a first end and a distal second end, an insulation layer overlying the conductor core, and a conductive shield layer overlying the insulation layer. The conductive shield layer further having a terminal end conductively connected with the conductive shield layer.