Abstract: A tip for a surgical instrument comprising a cradle that is moveably mounted to a distal end of an elongate shaft. The cradle is rotatable relative to the elongate shaft about a pitch axis. A member is pivotally coupled to the cradle to move with and relative to the cradle about a grip axis that is substantially orthogonal to the pitch axis. The member is movable relative to the cradle about a yaw axis. In some embodiments, there is a second member that is pivotally coupled to the cradle to move with and relative to the cradle about a second grip axis that is substantially orthogonal to the pitch axis. In some embodiments, the first member and second member are selectably movable relative to each other between a closed configuration in which the first member contacts the second member and an open configuration.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV capsid protein and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: The present invention provides recombinant AAV particles comprising an opsin transgene for therapy of retinal diseases, and related compositions and methods.

Abstract: A tip for a surgical instrument comprising a cradle that is moveably mounted to a distal end of an elongate shaft. The cradle is rotatable relative to the elongate shaft about a pitch axis. A member is pivotally coupled to the cradle to move with and relative to the cradle about a grip axis that is substantially orthogonal to the pitch axis. The member is movable relative to the cradle about a yaw axis. In some embodiments, there is a second member that is pivotally coupled to the cradle to move with and relative to the cradle about a second grip axis that is substantially orthogonal to the pitch axis. In some embodiments, the first member and second member are selectably movable relative to each other between a closed configuration in which the first member contacts the second member and an open configuration.

Abstract: A control system for a medical device includes: a first interface configured to control a position of the medical device; a second interface installed in a first portion of the handle grip and configured to control an end-effector orientation of an end-effector of the medical device; and a third interface installed in a second portion of the handle grip and configured to control a function of the end-effector. The first interface includes a handle grip coupled to a base member. The base member is coupled to a device attachment unit configured to couple to the medical device. The second interface is communicatively coupled to a sensor assembly that monitors movement detected at the second interface. The third interface is communicatively coupled to the sensor assembly to monitor movement detected at the third interface.

Abstract: The present disclosure relates to niraparib and abiraterone acetate, plus prednisone or prednisolone: for use in a method of improving the efficacy of treatment of metastatic castration-resistant prostate cancer (mCRPC) in a patient with DNA-repair anomalies, in particular for improving the median radiographic progression-free survival (rPFS).

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding human REP1, vectors, and host cells comprising codon optimized REP1 sequences, and methods of treating retinal disorders such as choroideremia comprising administering to the subject a codon optimized sequence encoding human REP1.

Abstract: Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and in clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more cells of the retina, for the treatment of retinal disorders and diseases.

Abstract: The present invention relates to a method of improving the efficacy of treatment of line 2+ metastatic castration-resistant prostate cancer (mCRPC) with biallelic DNA-repair anomalies in a male human, wherein said biallelic DNA-repair anomalies are selected from: i) BRCA (BRCA1, BRCA2, or a combination thereof), ii) non-BRCA (ATM, FANCA, PALB2, CHEK2, BRIP1, HDAC2, or any combination thereof): or iii) any combination thereof; wherein the male human has received prior taxane-based chemotherapy and androgen receptor (AR)-targeted therapy; said method of improving the efficacy of treatment comprising administering to said male human a once-daily oral dosing of 300 mg niraparib.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant A.AV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: A tip for a surgical instrument comprising a cradle that is moveably mounted to a distal end of an elongate shaft. The cradle is rotatable relative to the elongate shaft about a pitch axis. A member is pivotally coupled to the cradle to move with and relative to the cradle about a grip axis that is substantially orthogonal to the pitch axis. The member is movable relative to the cradle about a yaw axis. In some embodiments, there is a second member that is pivotally coupled to the cradle to move with and relative to the cradle about a second grip axis that is substantially orthogonal to the pitch axis. In some embodiments, the first member and second member are selectably movable relative to each other between a closed configuration in which the first member contacts the second member and an open configuration.

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding hum n alpha-galactosidase A, vectors, and host cells comprising codon optimized alpha-galactosidase A sequences, and methods of treating disorders such as Fabry disease comprising administering to the subject a codon optimized sequence encoding human alpha-galactosidase A.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding human alpha-galactosidase A, vectors, and host cells comprising codon optimized alpha-galactosidase A sequences, and methods of treating disorders such as Fabry disease comprising administering to the subject a codon optimized sequence encoding human alpha-galactosidase A.

Abstract: The present disclosure provides codon optimized RPGRorf15 sequences, vectors, and host cells comprising codon optimized RPGRorf15 sequences, and methods of treating retinal disorders such as XLRP comprising administering to the subject a codon optimized RPGRorf15 sequence.

Abstract: Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and in clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more cells of the retina for the treatment of retinal disorders and diseases.

Abstract: A flexible elongate shaft assembly which includes an elongate flexible tube having at least one joint built into the elongate flexible tube, and the at least one joint comprised of at least one notch. Each notch includes a contact-aided compliant notch topology built into the elongate flexible shaft configured to cause each notch to mechanically interfere with itself and self-reinforce during bending of each notch resulting in an increase in stiffness of each notch to prevent buckling and plastic deformation of the elongate flexible shaft assembly, and assume a predetermined and designed bending shape of the elongate flexible shaft assembly. The flexible elongate shaft assembly is incorporated into a flexible articulate surgical tool that provides the needed stiffness in order to be able to manipulate tissue and bear loads in anatomically confined spaces.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding human alpha-galactosidase A, vectors, and host cells comprising codon optimized alpha-galactosidase A sequences, and methods of treating disorders such as Fabry disease comprising administering to the subject a codon optimized sequence encoding human alpha-galactosidase A.

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding human REP1, vectors, and host cells comprising codon optimized REP1 sequences, and methods of treating retinal disorders such as choroideremia comprising administering to the subject a codon optimized sequence encoding human REP1.