Abstract: The present invention relates to a method for identifying nucleic acid segments which interact with a target nucleic acid segment or segments as well as kits for performing the method. The invention also relates to a method of identifying one or more interacting nucleic acid segments that are indicative of a particular disease.

Abstract: Mammalian cells are described that includes a recombination target site integrated within high integrating locus. Recombinant protein producer cell lines incorporating the mammalian cells and methods for forming the mammalian cells are also described. The high integrating loci have been developed through understanding and mapping of the three dimensional hierarchical structure of chromatin in mammalian cells. The high integrating loci are present in transcriptionally active environments that can provide both chromatin accessibility and epigenetic stability. As such, the recombinant mammalian cells can provide predictable and stable transgene production.

Abstract: Provided herein are methods for the treatment of disease with monoacylglycerol lipase (MAGL) inhibitors.

Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.

Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.

Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.

Abstract: Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.

Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.

Abstract: A stabilizer device for a work vehicle. The work vehicle having a first ground-engaging device having a first midpoint and a second ground-engaging device having a second midpoint. The first ground-engaging device and the second ground-engaging device configured to move the work vehicle along a surface. The stabilizer device comprising a mount coupled to the work vehicle between the first ground-engaging device and the second ground-engaging device. A stabilizer bar coupled to the mount. An actuator coupled to the mount and the stabilizer bar and configured to raise the stabilizer bar from a ground-engaging position to a stowed position. The stabilizer device extends to one of equal to and beyond the second midpoint in the ground-engaging position.

Abstract: Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.

Abstract: A storage apparatus for a work vehicle where the work vehicle comprises an operator's station defining a floor, a seat assembly coupled to the floor, wherein the seat assembly is rotatable about a seat assembly pivot axis between a forward facing position and a rearward facing position. The storage apparatus comprises at least one drawer support coupled to a backside of the seat assembly, and at least one drawer slidably disposed with the drawer support where the drawer is movable between an access position and a storage position.

Abstract: A stabilizer device for a work vehicle. The work vehicle having a first ground-engaging device having a first midpoint and a second ground-engaging device having a second midpoint. The first ground-engaging device and the second ground-engaging device configured to move the work vehicle along a surface. The stabilizer device comprising a mount coupled to the work vehicle between the first ground-engaging device and the second ground-engaging device. A stabilizer bar coupled to the mount. An actuator coupled to the mount and the stabilizer bar and configured to raise the stabilizer bar from a ground-engaging position to a stowed position. The stabilizer device extends to one of equal to and beyond the second midpoint in the ground-engaging position.

Abstract: A ballast device for a work vehicle. The ballast device comprising a rail coupled to the work vehicle. A carrier is slidingly coupled to the rail. The carrier comprises a pin having an axis of rotation. An actuator is coupled to the carrier and configured to move the carrier along the rail. A counterweight is rotatably coupled to the pin. A rotation device is coupled to the counterweight and configured for rotating the counterweight about the axis of rotation. A sensor is coupled to the work vehicle and configured for determining a center of gravity of the work vehicle and for generating a signal indicative of the center of gravity. A controller is configured for receiving the signal and configured for controlling the actuator and the rotation device to position the counterweight at an optimized location.

Abstract: A storage apparatus for a work vehicle where the work vehicle comprises an operator's station defining a floor, a seat assembly coupled to the floor, wherein the seat assembly is rotatable about a seat assembly pivot axis between a forward facing position and a rearward facing position. The storage apparatus comprises at least one drawer support coupled to a backside of the seat assembly, and at least one drawer slidably disposed with the drawer support where the drawer is movable between an access position and a storage position.

Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.

Abstract: A new and distinct Coprosma repens named ‘IGNITE’ is disclosed, characterized by Greyed-Purple foliage with a red and greyed-purple margin and glossy, ovate leaves. Plant habit is dense and round. The new cultivar is a Coprosma repens, typically suited for ornamental container and landscape use.

Abstract: The invention relates to a method for identifying nucleic acid segments which interact with a target nucleic acid segment by use of an isolating nucleic acid molecule, and to kits for use in said method. The invention also relates to a method of identifying one or more interacting nucleic acid segments that are indicative of a particular disease state.

Abstract: A new cultivar of Cordyline plant named ‘Salsa’ that is characterized by leaves that are linear in shape, initially erect then outwardly arching and dark red-purple in color with a pink midrib and pink margins.

Abstract: A new and distinct Coprosma repens named ‘IGNITE’ is disclosed, characterized by Greyed-Purple foliage with a red and greyed-purple margin and glossy, ovate leaves. Plant habit is dense and round. The new cultivar is a Coprosma repens, typically suited for ornamental container and landscape use.