Patents by Inventor Peter Frinking
Peter Frinking has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11752222Abstract: A method for preparing a suspension of “size-controlled” gas-filled microvesicles by microfluidic manufacturing techniques, which comprises using a gaseous flow comprising a first gas having high solubility in water and a second gas having low 5 solubility in water.Type: GrantFiled: March 4, 2019Date of Patent: September 12, 2023Assignee: Bracco Suisse SAInventors: Tim Segers, Emmanuel Gaud, Gilles Casqueiro, Peter Frinking, Anne Lassus
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Patent number: 11607196Abstract: An embodiment includes analyzing a body part perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with at least a first passage during an analysis interval. The analyzing includes providing at least one input signal indicative of a response to an interrogation signal of a corresponding location of the body part during the analysis interval, and fitting each input signal over the analysis interval by an instance of a combined bolus function of time, based on a combination of a first simple bolus function of time modeling the first passage of the contrast agent and at least one second simple bolus function of time each one modeling a corresponding second passage of the contrast agent.Type: GrantFiled: October 22, 2018Date of Patent: March 21, 2023Assignee: BRACCO SUISSE SAInventors: Peter Frinking, Nicolas Rognin, Marcel Arditi
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Patent number: 10918605Abstract: A method for preparing a suspension of size-controlled microparticles stabilized by a layer of amphiphilic material. The method, which may be applied to preparations using microfluidic techniques, comprises controlling the temperature of the microparticles during the preparation process and preferably while collecting the formed microparticles.Type: GrantFiled: August 30, 2017Date of Patent: February 16, 2021Assignee: Bracco Suisse SAInventors: Tim Segers, Peter Frinking, Anne Lassus, Philippe Bussat, Emmanuel Gaud, Samir Cherkaoui
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Patent number: 10433817Abstract: A solution is proposed for analyzing a body-part of a patient, the body-part having been perfused before performing the method with a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target.Type: GrantFiled: December 6, 2016Date of Patent: October 8, 2019Assignee: Bracco Suisse S.A.Inventors: Peter Frinking, Jean-Marc Hyvelin, Thomas Fresneau
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Patent number: 10368842Abstract: A method is provided for use with an ultrasound scanner, wherein an estimate value (particularly, a power level of the ultrasound scanner that is required to apply a desired acoustic pressure level to the body-part, the acoustic pressure level that is actually applied to the body-part when a specific power level is set, an acoustic attenuation that occurs within a patient between a transducer of the ultrasound scanner and the body-part and/or the acoustic attenuation that occurs within the patient between different body-parts) is determined according to a comparison between measurement data (based on a measurement response comprising a non-fundamental component of a measurement echo signal received in response to a measurement excitation signal) and corresponding reference data. Corresponding computer program product, system, therapeutic method, and diagnostic method are also provided.Type: GrantFiled: April 3, 2015Date of Patent: August 6, 2019Assignee: Bracco Suisse S.A.Inventors: Gilles Casqueiro, Emmanuel Gaud, Marcel Arditi, Peter Frinking
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Patent number: 10278612Abstract: A solution for diagnostic applications is proposed. Particularly, a corresponding diagnostic system includes means (903-906) for providing (A1-A3) a plurality of input signals representative of a body-part being perfused with a contrast agent over time, each input signal being indicative of a response to an interrogating stimulus of a corresponding location of the body-part possibly including the contrast agent, means (909-930) for generating (A4.1-A4.3) a plurality of filtered signals from selected input signals of selected locations, each filtered signal at each instant over time being generated from a corresponding selected input signal according to a portion of the selected input signal including said instant, and means (933-939) for monitoring (A4.4-A4.Type: GrantFiled: November 23, 2009Date of Patent: May 7, 2019Assignee: Bracco Suisse SAInventors: Peter Frinking, Laurent Mercier, Nicolas Rognin, Marcel Arditi
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Publication number: 20190053791Abstract: An embodiment is proposed for analyzing a body-part perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with a first passage and possibly with at least one second passage during an analysis interval.Type: ApplicationFiled: October 22, 2018Publication date: February 21, 2019Applicant: Bracco Suisse S.A.Inventors: Peter Frinking, Nicolas Rognin, Marcel Arditi
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Publication number: 20180353158Abstract: A solution is proposed for analyzing a body-part of a patient, the body-part having been perfused before performing the method with a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target.Type: ApplicationFiled: December 6, 2016Publication date: December 13, 2018Applicant: Bracco Suisse SAInventors: Peter Frinking, Jean-Marc Hyvelin, Thomas Fresneau
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Patent number: 10130342Abstract: An embodiment includes analyzing a body part perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with at least a first passage during an analysis interval. The analyzing includes providing at least one input signal indicative of a response to an interrogation signal of a corresponding location of the body part during the analysis interval, and fitting each input signal over the analysis interval by an instance of a combined bolus function of time, based on a combination of a first simple bolus function of time modeling the first passage of the contrast agent and at least one second simple bolus function of time each one modeling a corresponding second passage of the contrast agent.Type: GrantFiled: September 7, 2012Date of Patent: November 20, 2018Assignee: Bracco Suisse SAInventors: Peter Frinking, Nicolas Rognin, Marcel Arditi
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Patent number: 10076580Abstract: The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-linear echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different median sizes. In particular, said preparations preferably have size distributions with respective DV50 values differing from each other by at least 0.5 ?m, more preferably at least 1.0 ?m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher.Type: GrantFiled: December 28, 2015Date of Patent: September 18, 2018Assignee: BRACCO SUISSE S.A.Inventors: Philippe Bussat, Peter Frinking, Christian Guillot, Michel Schneider
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Patent number: 9734584Abstract: An embodiment of a segmentation solution for use in diagnostic imaging applications is proposed. A corresponding embodiment of a data-processing segmentation method comprises: providing a representation over a non-zero analysis time period of a body-part being perfused with a contrast agent, the representation comprising, for each location of a set of locations of the body-part, an indication of a response over the analysis time period of the location to an interrogation signal; calculating, for each selected location of a set of selected locations, the value of at least one statistical parameter of a statistical distribution of the response over the analysis time period of the selected location, the set of selected locations comprising all the locations or a part thereof; and segmenting the selected locations according to a comparison between the values of said at least one statistical parameter for the selected locations with at least one segmentation threshold.Type: GrantFiled: December 18, 2013Date of Patent: August 15, 2017Assignee: Bracco Suisse SAInventor: Peter Frinking
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Publication number: 20170027545Abstract: A solution for use with an ultrasound scanner is proposed.Type: ApplicationFiled: April 3, 2015Publication date: February 2, 2017Inventors: Gilles Casqueiro, Emmanuel Gaud, Marcel Arditi, Peter Frinking
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Publication number: 20160184464Abstract: The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-linear echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different median sizes. In particular, said preparations preferably have size distributions with respective DV50 values differing from each other by at least 0.5 ?m, more preferably at least 1.0 ?m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher.Type: ApplicationFiled: December 28, 2015Publication date: June 30, 2016Applicant: BRACCO SUISSE S.A.Inventors: Philippe Bussat, Peter Frinking, Christian Guillot, Michel Schneider
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Patent number: 9375397Abstract: Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.Type: GrantFiled: April 28, 2011Date of Patent: June 28, 2016Assignee: BRACCO SUISSE S.A.Inventors: Thierry Bettinger, Feng Yan, Sophie Mehier-Humbert, Peter Frinking
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Patent number: 9307957Abstract: A data-processing method includes providing a parametric map including a plurality of parameter values, each one characterizing a corresponding location of a body-part. The method includes determining at least one statistical indicator of at least one distribution of a plurality of analysis parameter values corresponding to selected analysis locations, each statistical indicator being indicative of a condition of an analysis region of the body-part defined by the analysis locations.Type: GrantFiled: June 8, 2010Date of Patent: April 12, 2016Assignee: BRACCO SUISSE SAInventors: Peter Frinking, Marcel Arditi, Laurent Mercier, Nicolas Rognin, Eric Allemann
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Patent number: 9248204Abstract: The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-liner echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different mean sizes. In particular, said preparations preferably have size distributions with respective DV50 values differing from each other by at least 0.5 ?m, more preferably at least 1.0 ?m. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher.Type: GrantFiled: August 17, 2005Date of Patent: February 2, 2016Assignee: Bracco Suisse S.A.Inventors: Philippe Bussat, Peter Frinking, Christian Guillot, Michel Schneider
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Patent number: 9198639Abstract: A system for facilitating the detection of an immobilized contrast agent in medical imaging applications is proposed.Type: GrantFiled: November 9, 2006Date of Patent: December 1, 2015Assignee: BRACCO SUISSE S.A.Inventors: Peter Frinking, Marcel Arditi, Nicolas Rognin, Feng Yan
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Patent number: 9072492Abstract: An embodiment analyzes a body part of a patient, which patient is perfused with a contrast agent that is capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system provides an echo signal that is indicative of a response over time to an interrogation signal of the body part, fits the echo signal with a time model function that models an evolution over time of the contrast agent in the body part, the time model function including a combination of a circulation function that models the circulation of the contrast agent and a decay function that models a decay of the echo signal from the immobilized contrast agent, and estimates at least one kinetics indicator of the contrast agent from the time model function.Type: GrantFiled: December 23, 2008Date of Patent: July 7, 2015Assignee: BRACCO SUISSE SAInventors: Marcel Arditi, Tristan Messager, Michel Schneider, Peter Frinking
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Patent number: 8929634Abstract: An embodiment for analyzing a body-part of a patient is proposed.Type: GrantFiled: September 1, 2010Date of Patent: January 6, 2015Assignee: Bracco Suisse SAInventors: Nicolas Rognin, Marcel Arditi, Laurent Mercier, Peter Frinking
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Patent number: 8634608Abstract: An embodiment of a system is proposed for imaging a body part including a tissue, the body part being perfused with a contrast agent. The system includes means for providing a sequence of original images offering a digital representation over time of the body-part, each original image including a plurality of original values each one indicative of a response to an interrogation signal of a corresponding location of the body-part possibly including the contrast agent with a contribution of the tissue substantially reduced.Type: GrantFiled: November 10, 2006Date of Patent: January 21, 2014Assignee: Bracco Suisse S.A.Inventors: Peter Frinking, Nicolas Rognin, Marcel Arditi