Patents by Inventor Peter Fuhrken
Peter Fuhrken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10604739Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.Type: GrantFiled: April 27, 2017Date of Patent: March 31, 2020Assignee: FUJIFILM Cellular Dynamics, Inc.Inventors: Casey Stankewicz, Matt Riley, Nathaniel Beardsley, Wen Bo Wang, Peter Fuhrken, Steven Kattman
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Patent number: 9957482Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.Type: GrantFiled: March 23, 2015Date of Patent: May 1, 2018Assignee: Cellular Dynamics International, Inc.Inventors: Casey Stankewicz, Matt Riley, Nathaniel Beardsley, Wen Bo Wang, Peter Fuhrken, Steven Kattman
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Publication number: 20170226481Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.Type: ApplicationFiled: April 27, 2017Publication date: August 10, 2017Applicant: Cellular Dynamics International, Inc.Inventors: Casey STANKEWICZ, Matt RILEY, Nathaniel BEARDSLEY, Wen Bo WANG, Peter FUHRKEN, Steven KATTMAN
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Patent number: 9365827Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.Type: GrantFiled: March 11, 2013Date of Patent: June 14, 2016Assignee: Cellular Dynamics International, Inc.Inventors: Casey Stankewicz, Matt Riley, Nathaniel Beardsley, Wen Bo Wang, Peter Fuhrken, Steven Kattman
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Patent number: 9181529Abstract: Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage.Type: GrantFiled: October 19, 2011Date of Patent: November 10, 2015Assignee: Cellular Dynamics International, Inc.Inventors: Steven Kattman, Wen Bo Wang, Peter Fuhrken, Nathan Meyer, Matthew George, Casey Stankewicz
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Publication number: 20150191697Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.Type: ApplicationFiled: March 23, 2015Publication date: July 9, 2015Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.Inventors: Casey STANKEWICZ, Matt RILEY, Nathaniel BEARDSLEY, Wen Bo WANG, Peter FUHRKEN, Steven KATTMAN
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Patent number: 8557580Abstract: The present invention provides methods and compositions for the production of hematopoietic progenitor cells or endothelial progenitor cells from human pluripotent stem cells using a defined cell culture medium without the need to utilize feeder cells or serum. In some embodiments, differentiation is accomplished using hypoxic atmospheric conditions. The defined medium of the present invention may contain growth factors and a matrix component. The hematopoietic progenitor cells may be further differentiated into cell lineages including red blood cells, macrophages, granulocytes, and megakaryocytes. The endothelial progenitor cells may be further differentiated into endothelial cells. Also disclosed are screening assays for identification of candidate substances that affect differentiation of pluripotent stem cells into progenitor cells.Type: GrantFiled: February 22, 2010Date of Patent: October 15, 2013Assignee: Cellular Dynamics International, Inc.Inventors: Christine Daigh, Peter Fuhrken, Giorgia Salvagiotto
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Patent number: 8415155Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.Type: GrantFiled: October 19, 2010Date of Patent: April 9, 2013Assignee: Cellular Dynamics International, Inc.Inventors: Casey Stankewicz, Matt Riley, Nathaniel Beardsley, Wen Bo Wang, Peter Fuhrken, Steven Kattman
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Publication number: 20120129211Abstract: Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage.Type: ApplicationFiled: October 19, 2011Publication date: May 24, 2012Inventors: STEVEN KATTMAN, Wen Bo Wang, Peter Fuhrken, Nathan Meyer, Matthew George, Casey Stankewicz
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Publication number: 20110097799Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.Type: ApplicationFiled: October 19, 2010Publication date: April 28, 2011Inventors: Casey Stankewicz, Matt Riley, Nathaniel Beardsley, Wen Bo Wang, Peter Fuhrken, Steven Kattman
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Publication number: 20100216181Abstract: The present invention provides methods and compositions for the production of hematopoietic progenitor cells or endothelial progenitor cells from human pluripotent stem cells using a defined cell culture medium without the need to utilize feeder cells or serum. In some embodiments, differentiation is accomplished using hypoxic atmospheric conditions. The defined medium of the present invention may contain growth factors and a matrix component. The hematopoietic progenitor cells may be further differentiated into cell lineages including red blood cells, macrophages, granulocytes, and megakaryocytes. The endothelial progenitor cells may be further differentiated into endothelial cells. Also disclosed are screening assays for identification of candidate substances that affect differentiation of pluripotent stem cells into progenitor cells.Type: ApplicationFiled: February 22, 2010Publication date: August 26, 2010Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.Inventors: Christine Daigh, Peter Fuhrken, Giorgia Salvagiotto