Abstract: A heat exchanger including a first heat absorbing section and a second heat releasing section, such that a plurality of heat exchange structures are arranged, preferably in parallel, in a plane of extension. The first heat absorbing section includes a first plurality of fluid guiding devices and the second heat releasing section comprises a second plurality of fluid guiding devices. Each heat exchange structure includes at least one fluid guiding devices of the first plurality and at least one fluid guiding devices of the second plurality thermally connected to each other, and preferably arranged in parallel. A clearance disposed between two adjacent heat exchange structures allows airflow between adjacent heat exchange structures and/or each heat exchange structure includes a heat sink to thermally couple the fluid guiding devices of the first plurality and the fluid guiding devices of the second plurality.

Abstract: The instant invention provides compounds which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: An exercise device is provided that replicates on dry land the movement and resistance of a paddling motion. The exercise device includes a hollow upper shaft, a handle connected to an upper end of the upper shaft, and a lower shaft coupled at least partially within the upper shaft by a spring, to allow retraction into and extension from the upper shaft. The exercise device further includes a blade replacement assembly connected with a bottom end of the lower shaft, the blade replacement assembly comprising one or more wheels connected with a bottom end of the lower shaft and a resistance mechanism to provide resistance against a rolling direction of the one or more wheels.

Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.

Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.

Abstract: Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: A refrigeration load reduction system can include a primary container having gas permeable openings therein. A granular composition is retained within the container. The granular composition is a granular mixture of a sodium carbonate mineral and a mono-, di- or tricarboxylic acid. Typically, the sodium carbonate mineral is a trona mineral, although other minerals can be used singly or in combination with trona. A method of reducing refrigeration load can include orienting the refrigeration load reduction system within a fluid circulation path of a refrigeration unit adapted to cool a refrigeration chamber.

Abstract: The subject matter disclosed herein relates to a system for a water-going board that boosts the forward momentum of the board. This system may include a board having a bottom surface. The system may also include one or more cavities formed in the bottom surface of the board. These cavities may be configured to catch forward-moving energy of water moving forward relative to the board, while allowing passage of rearward-moving energy of water moving rearward relative to the board.

Abstract: An exercise device is provided that replicates on dry land the movement and resistance of a paddling motion. The exercise device includes a hollow upper shaft, a handle connected to an upper end of the upper shaft, and a lower shaft coupled at least partially within the upper shaft by a spring, to allow retraction into and extension from the upper shaft. The exercise device further includes a blade replacement assembly connected with a bottom end of the lower shaft, the blade replacement assembly comprising one or more wheels connected with a bottom end of the lower shaft and a resistance mechanism to provide resistance against a rolling direction of the one or more wheels.

Abstract: A social opinion system and method are disclosed. Questions or statements are generated and sent electronically to a plurality of users of a social networking service. A simple response mechanism is generated for display in a user interface with the questions or statements. Data characterizing responses provided by the plurality of users using the simple response mechanism are received by a computer. Real-time information related to the questions or statements is generated by the computer, and provided from the computer via a communication network to at least one designated recipient.

Abstract: The subject matter disclosed herein relates to a system for a water-going board that boosts the forward momentum of the board. This system may include a board having a bottom surface. The system may also include one or more cavities formed in the bottom surface of the board. These cavities may be configured to catch forward-moving energy of water moving forward relative to the board, while allowing passage of rearward-moving energy of water moving rearward relative to the board.

Abstract: A computer-implemented method for generating and distributing electronic trading cards, such as for use with mobile devices, generates instances of electronic trading cards and distributes the instances to users over a computer network. A finite number of instances of each electronic trading card may be generated. Electronic trading card instances may include an image and a digital watermark. Each instance of an electronic trading card may have a unique identifier. One instance of an electronic trading card may include content that is not included on all other instances of the same card. A randomly-generated “pack” of cards may be purchased by and distributed to the user. The contents of the pack may not be made visible to the user until completion of the purchase. Users may purchase additional features, such as a guarantee that the user will not be provided with duplicate instances of any trading card.