Abstract: The invention relates to a pressure sensor comprising a sensor element (2) having a flat membrane (4) which is transformed at its edge into a hollow-cylindrical ring (6) so that a central recess (20) is provided at the lower side (10) of the membrane (4). On the upper side (8) of the membrane (4) a resistance arrangement consisting of electric resistors is disposed. A sleeve (54) projects into the recess (20) and supports a first elastomeric sealing ring (66) which is tightly arranged at the circumferential area of the recess (20). Furthermore the sleeve (54) supports a second elastomeric sealing ring (68) which serves for sealing at a feeding tube for pressure fluid formed in a component part to which the pressure sensor is mountable. The sleeve (54) is rigidly connected to a disk (56) which is attached with its outer edge (58) to a casing (26) enclosing the sensor element (2).

Abstract: The present invention relates to the new use of 2,4-diamino-3-hydroxycarboxylic acids of formula (I), in which A and B independently represent a bond or an unsubstituted or substituted amino acyl moiety; R1 represents hydrogen; an amino protecting group; or a group of formula R5Y— wherein R5 represents hydrogen or an unsubstituted or substituted alkyl, alkenyl, alkinyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl group; and Y represents —CO—; —NH—CO—; —NH—CS—; —SO2—; —O—CO—; or —O—CS—; R2 represents the side chain of a natural amino acid; an alkyl, arylalkyl, heteroarylalkyl or cycloalkylalkyl group; or trimethylsilylmethyl, 2-thienylmethyl or styrylmethyl; R3 represents halogen, alkyl, alkoxy or hydroxyalkoxy; and R4 represents 2(R)-hydroxyindan-1(S)-yl; (S)-2-hydroxy-1-phenylethyl; or 2-hydroxy-benzyl unsubstituted or substituted in 4-position by methoxy; in the manufacture of a pharmaceutical composition for the treatment of a proliferative disease, e.g.

Abstract: The invention relates to a pressure sensor comprising a sensor element (2) having a flat membrane (4) which is transformed at its edge into a hollow-cylindrical ring (6) so that a central recess (20) is provided at the lower side (10) of the membrane (4). On the upper side (8) of the membrane (4) a resistance arrangement consisting of electric resistors is disposed. A sleeve (54) projects into the recess (20) and supports a first elastomeric sealing ring (66) which is tightly arranged at the circumferential area of the recess (20). Furthermore the sleeve (54) supports a second elastomeric sealing ring (68) which serves for sealing at a feeding tube for pressure fluid formed in a component part to which the pressure sensor is mountable. The sleeve (54) is rigidly connected to a disk (56) which is attached with its outer edge (58) to a casing (26) enclosing the sensor element (2).

Abstract: The present invention relates to processes for determining the biological activity of compounds that inhibit the tyrosine kinase activity of the Epidermal Growth Factor Receptor (EGFR) aqnd to the use of transcription or translation products of genes the expression levels of which correlate with the biological activity of an EGFR tyrosine kinase inhibitor for determining the biological activity of such an EGFR tyrosine kinase inhibitor.

Abstract: A lighting device for attachment to a motor vehicle inside a housing 4. One or more light emitting diodes 9 which emit substantially white light are employed as lighting emitters. On account of the small amount of waste heat of the light-emitting diodes 9 the lighting device can be particularly easily integrated into existing subassemblies of the motor vehicle, in particular into the outside mirrors, inside mirror, trim strips and door handles, and can serve to illuminate the region around the vehicle or the interior of the vehicle.

Abstract: A lighting device for attachment to a motor vehicle inside a housing 4. One or more light emitting diodes 9 which emit substantially white light are employed as lighting emitters. On account of the small amount of waste heat of the light-emitting diodes 9 the lighting device can be particularly easily integrated into existing subassemblies of the motor vehicle, in particular into the outside mirrors, inside mirror, trim strips and door handles, and can serve to illuminate the region around the vehicle or the interior of the vehicle.

Abstract: A lighting device for attachment to a motor vehicle inside a housing 4. One or more light emitting diodes 9 which emit substantially white light are employed as lighting emitters. On account of the small amount of waste heat of the light-emitting diodes 9 the lighting device can be particularly easily integrated into existing subassemblies of the motor vehicle, in particular into the outside mirrors, inside mirror, trim strips and door handles, and can serve to illuminate the region around the vehicle or the interior of the vehicle.

Abstract: A lighting device (26) for arrangement on the external or internal rear view mirror of a motor vehicle is provided with a light source (27), the light rays of which emerge at a mirror housing opening and are deflected at a transparent light refraction element (33) arranged in the beam path. The plate-like light refraction element (33) has, at least on one side, a surface structure (36) by means of which the light refraction element is divided into several light refraction zones. To achieve a deflection of the light into a preferred direction the light refraction element (33) is designed in the manner of a Fresnel prism (33), the light refraction zones corresponding to prism zones of a prism body which are pushed together in stepwise manner. To intensify the deflection of the light beam into the preferred direction a decentralized condenser lens (31) may be arranged in front of the Fresnel prism (33).

Abstract: We have found that Deprenyl® induces a novel polypeptide in neural cells. This polypeptide has the structure given in SEQ ID No. 1 and is referred to herein as DIP 1 (Deprenyl® Induced Protein 1).

Abstract: A lighting device for attachment to a motor vehicle inside a housing 4. One or more light emitting diodes 9 which emit substantially white light are employed as lighting emitters. On account of the small amount of waste heat of the light-emitting diodes 9 the lighting device can be particularly easily integrated into existing subassemblies of the motor vehicle, in particular into the outside mirrors, inside mirror, trim strips and door handles, and can serve to illuminate the region around the vehicle or the interior of the vehicle.

Abstract: A cap for an external side view mirror for a motor vehicle which facilitates the ability of an observer to determine the position of the vehicle. To accomplish this, a light-reflecting strip or triangular pyramidal reflector prisms, for example, are applied to the cap.

Abstract: The invention concerns a method for the production of a polypeptide with the aid of genetically engineered yeast cells which contain not more than one functional CUP1 gene in the genome and carry a plasmid comprising a gene coding for said polypeptide and a functional CUP1 gene; and said yeast cells and said plasmids.

Abstract: A novel process for the production of recombinant desulphatohirudin by transformed yeast strains is provided. The process makes use of an expression cassette comprising the yeast CUP1 promoter. The invention concerns also said transformed yeast strains, novel expression vectors and methods for the production thereof.

Abstract: A wide angle lens for a vehicle rear window is movably held in a guide device which is fixed to the body of the vehicle. The lens can be moved out of the rear view field of vision of the driver for normal forward driving namely, it can be moved along the guide device. The lens is brought into the rearward field of vision only when the vehicle is to be maneuvered in reverse.

Abstract: N-N-bis-L-amino acid-L-cystine- peptides which are suitable as water soluble cystine donors in oral or parenteral nutrition.