Patents by Inventor Peter G. Edelman
Peter G. Edelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7332566Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.Type: GrantFiled: December 2, 2005Date of Patent: February 19, 2008Assignee: Incept LLCInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Patent number: 7009034Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.Type: GrantFiled: November 9, 2001Date of Patent: March 7, 2006Assignee: Incept, LLCInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Publication number: 20040192582Abstract: Provided are ingestible polymeric formulations and oral dosage forms for the reduction of gastric volume in the treatment of overweight and obese patients. The formulation includes an acid-sensitive, gelatin coating over a dehydrated hydrophilic polymer. When ingested, the acid-sensitive coating is quickly dissolved by gastric secretions and the hydrophilic polymer is exposed to the aqueous environment of the gastric milieu. The polymer absorbs water and expands to the point that will not allow the polymer to pass beyond the pyloric valve, and the expanded polymer is therefore trapped in the stomach.Type: ApplicationFiled: December 19, 2003Publication date: September 30, 2004Inventors: Daniel R. Burnett, Peter G. Edelman
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Publication number: 20040191277Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other usefull medical and surgical purposes.Type: ApplicationFiled: March 5, 2004Publication date: September 30, 2004Applicant: Incept LLCInventors: Amarpreet S. Sawhney, Peter G. Edelman, Steven L. Bennett
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Patent number: 6703047Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.Type: GrantFiled: February 2, 2001Date of Patent: March 9, 2004Assignee: Incept LLCInventors: Amarpreet S. Sawhney, Peter G. Edelman
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Publication number: 20040023842Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.Type: ApplicationFiled: February 24, 2003Publication date: February 5, 2004Applicant: InceptInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Publication number: 20030162841Abstract: Biocompatible crosslinked-polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.Type: ApplicationFiled: February 25, 2003Publication date: August 28, 2003Applicant: InceptInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Patent number: 6610033Abstract: The present invention provides apparatus and methods for making and using a medicinal polymer formed from two components. The apparatus includes a double syringe holder housing first and second syringes that is adapted to be coupled with a predetermined orientation to a double vial holder housing first and second vials. The double syringe holder and double vial holder have mating key features that prevent the first syringe from being coupled to the second vial and the second syringe from being coupled to the first vial. The apparatus also includes a delivery device having first and second inlet ports and a key feature that prevents the first syringe from being coupled to the second inlet port and the second syringe from being coupled to the first inlet port.Type: GrantFiled: October 13, 2000Date of Patent: August 26, 2003Assignee: Incept, LLCInventors: David A. Melanson, Michelle D. Lyman, Peter G. Edelman, Amarpreet S. Sawhney
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Patent number: 6566406Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.Type: GrantFiled: December 3, 1999Date of Patent: May 20, 2003Assignee: Incept, LLCInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Publication number: 20030012734Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.Type: ApplicationFiled: November 9, 2001Publication date: January 16, 2003Applicant: Incept LLC.Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Publication number: 20020106409Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.Type: ApplicationFiled: February 2, 2001Publication date: August 8, 2002Inventors: Amarpreet S. Sawhney, Peter G. Edelman
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Patent number: 6068748Abstract: A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. The working electrode may be defined by an open printed region of the dielectric, or by a needle-punched or laser-burned hole or opening in the dielectric which exposes a small region of one of the conduct strips. A solid electrolyte contacting the electrodes is covered by a semipermeable membrane which may comprise an acrylonitrile butadiene copolymer or an acrylate-based copolymer. A sample chamber is defined by the membrane, a cover member, and a gasket therebetween, and has a volume of from about 1 to about 2 .mu.l. The gasket is formulated from the highly cross-linked polymerization product of epichlorohydrin. All sensor components are selected such that a sensor operable for at least 2 days under normal conditions is produced.Type: GrantFiled: August 25, 1997Date of Patent: May 30, 2000Inventors: Joseph Berger, Peter G. Edelman
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Patent number: 5770028Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: December 19, 1996Date of Patent: June 23, 1998Assignee: Chiron Diagnostics CorporationInventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Peter G. Edelman
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Patent number: 5711868Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: January 27, 1998Assignee: Chiron Diagnostics CorporatiionInventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: 5616222Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: April 1, 1997Assignee: Chiron Diagnostics CorporationInventors: Thomas C. Maley, Paul A. D'Orazio, Peter G. Edelman, John A. Zalenski
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Patent number: 5601694Abstract: A solid shale, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: July 27, 1995Date of Patent: February 11, 1997Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: 5595646Abstract: A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. The working electrode may be defined by an open printed region of the dielectric, or by a needle-punched or laser-burned hole or opening in the dielectric which exposes a small region of one of the conductive strips. A solid electrolyte contacting the electrodes is covered by a semipermeable membrane which may comprise an acrylonitrile butadiene copolymer or an acrylate-based copolymer. A sample chamber is defined by the membrane, a cover member, and a gasket therebetween, and has a volume of from about 1 to about 2 .mu.m. The gasket is formulated from the highly cross-linked polymerization product of epichlorohydrin. All sensor components are selected such that a sensor operable for at least 2 days under normal conditions is produced.Type: GrantFiled: August 24, 1995Date of Patent: January 21, 1997Assignee: Ciba Corning Diagnostics Corp.Inventors: Joseph S. Foos, Peter G. Edelman, James E. Flaherty, Joseph Berger
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Patent number: 5573647Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: November 12, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason, Robert R. McCaffrey, John A. Zalenski
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Patent number: 5529676Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: June 25, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason, Robert R. McCaffrey, John A. Zalenski
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Patent number: 5518601Abstract: A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. The working electrode may be defined by an open printed region of the dielectric, or by a needle-punched or laser-burned hole or opening in the dielectric which exposes a small region of one of the conductive strips. A solid electrolyte contacting the electrodes is covered by a semipermeable membrane which may comprise an acrylonitrile butadiene copolymer or an acrylate-based copolymer. A sample chamber is defined by the membrane, a cover member, and a gasket therebetween, and has a volume of from about 1 to about 2 N.L. The gasket is formulated from the highly cross-linked polymerization product of epichlorohydrin. All sensor components are selected such that a sensor operable for at least 2 days under normal conditions is produced.Type: GrantFiled: August 24, 1995Date of Patent: May 21, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Joseph S. Foos, Peter G. Edelman, James E. Flaherty, Joseph Berger