Abstract: Apparatus for performing multiple different measurements on a small specimen sample, enabling testing and diagnoses in real time at the point of care are described. The core of the apparatus includes an ultrasonic resonator cavity where acoustic resonances are used to determine the speed of sound and sound attenuation in a single droplet. Acoustic measurements are made in the reflection mode using electrical impedance of a small piezoelectric crystal transducer that operates in the thickness longitudinal mode. Combination of this technology with electromagnetic, electrical, and magnetic fields permits multiple types of measurements to be made using the same resonator cavity.

Abstract: In one aspect, a method and system for detecting a change in fluid dynamics of a fluid flowing through an extra-corporeal circuit is disclosed, which includes establishing an acoustic wave resonance across a transverse dimension of at least a portion of a line associated with the extra-corporeal circuit through which the fluid flows, monitoring a phase signal of the resonant acoustic wave, and identifying occurrence of a change in fluid dynamics of the flowing fluid when the observed phase signal of the resonant acoustic wave indicates a deviation from the expected fluid flow signature. The change in fluid dynamics can be used to indicate a venous needle dislodgement event.

Abstract: Apparatus for performing multiple different measurements on a small specimen sample, enabling testing and diagnoses in real time at the point of care are described. The core of the apparatus includes an ultrasonic resonator cavity where acoustic resonances are used to determine the speed of sound and sound attenuation in a single droplet. Acoustic measurements are made in the reflection mode using electrical impedance of a small piezoelectric crystal transducer that operates in the thickness longitudinal mode. Combination of this technology with electromagnetic, electrical, and magnetic fields permits multiple types of measurements to be made using the same resonator cavity.