Abstract: Various methods and systems are provided for segmenting heart sounds. In one example, a method includes receiving a phonocardiogram (PCG) signal of a patient, processing the PCG signal to detect a plurality of candidate sounds in the PCG signal, extracting, for each candidate sound, one or more features from the processed PCG signal, entering the one or more extracted features as input to a segmentation model trained to label each candidate sound as an S1 sound, an S2 sound, or neither, receiving output from the segmentation model, and displaying and/or storing the output from the segmentation model.

Abstract: The present disclosure provides methods of measuring of an analyte in a subject to remove a measurement artifact by using a forecasting model to determine the true analyst concentration in a subject. Also herein, the present disclosure provides parameters and models to estimate the true analyte concentration in a subject.

Abstract: Disclosed are techniques for supporting glucoregulatory management decisions using a decision support recommender to predict an occurrence of a hypoglycemic event in an incognizant living subject. Glucose management data is obtained from a living subject. It is processed as prescribed by a feature extractor to generate a set of glucoregulatory feature values. The glucoregulatory feature values are applied as prescribed by the feature extractor to a hypoglycemia prediction model. The hypoglycemia prediction model is formulated to predict the occurrence of a hypoglycemic event during a period of incognizance of the living subject. A glucoregulatory management recommendation is generated as prescribed by the decision support recommender if the hypoglycemia prediction model predicts the occurrence of a hypoglycemic event during the period of incognizance.

Abstract: A sensing assembly (10), including a body (12) and one or more first indicating electrodes disposed on the body (26). The first indicating electrodes include an electrochemically active layer (32) and a layer (38) of an active functioning enzyme of a first enzyme type on top of the electrochemically active layer. Also, one or more second indicating electrodes (24) are disposed on the body and include an electrochemically active layer (32) and a layer (36) of an inactivated enzyme of the first enzyme type on top of the electrochemically active layer. A reference electrode (22) is also disposed on the body. Finally, an electrical and data processing system (18) is adapted to bias the electrodes and measure electrical signals from the electrodes, and uses said signals to determine an analyte concentration and communicates the analyte concentration to a location apart from the first and second indicating electrodes.

Abstract: The invention relates to a system and method for monitoring the location, movement and health of one or more individuals within an environment by a monitoring individual, such as a care giver. The system used includes optional monitoring devices including a wireless transceiver, access point devices including a wireless transceiver, a hub access point device including a wireless transceiver, and a local computing device. The system is programmed such that it has the capability to operate with or without the measure of time of flight value from the optional monitoring devices such that the system has the capability of monitoring the location, movement and health of an individual whether or not the individual is wearing the monitoring device.

Abstract: The invention relates to a system and method for monitoring the location, movement and health of one or more individuals within an environment by a monitoring individual, such as a care giver. The system used includes optional monitoring devices including a wireless transceiver, access point devices including a wireless transceiver, a hub access point device including a wireless transceiver, and a local computing device. The system is programmed such that it has the capability to operate with or without the measure of time of flight value from the optional monitoring devices such that the system has the capability of monitoring the location, movement and health of an individual whether or not the individual is wearing the monitoring device.

Abstract: Methods and compositions for the non-invasive determination of the concentration of an analyte are provided.

Abstract: Embodiments of the present invention improve the accuracy of measurements and/or in vivo calibrations of a biosensor by (1) using more than one sensor signal value and/or more than one directly sampled and measured value, such as a capillary blood glucose value, and/or by (2) delaying the acquisition of a sensor output value that is compared with a directly sampled and measured value, such as a capillary blood glucose value, during a calibration. In an embodiment of the present invention, the median of a series of measured values, or a median or mean of the medians, may be utilized to provide more consistent and accurate measurement data and/or to compensate for error or artifact.

Abstract: Methods and compositions for the non-invasive determination of the concentration of an analyte are provided.

Abstract: The present invention relates generally to the field of healthcare. Particularly, in the remote monitoring and modulation of a medical device on or in a subject. The present invention provides both systems and methods for remote monitoring of a subject, as well remote treatment of a subject (e.g. modulation of a medical device).

Abstract: An interferometric fibre optic network includes a downlead optical fibre (12) and a pair of uplead optical fibres (14, 16). Sites for a plurality of interferometric sensor pairs (25) are arranged whereby each pair (25) is optically connected in use of the network to the downlead and uplead fibers (12, 14, 16) via a 3.times.3 fibre optic coupler (30) and respective further fibre optic couplers (32) on the uplead fibres (14, 16). The uplead fibres (14, 16) are multimode optical fibres, and each of the 3.times.3 couplers (30) is optically connected to the respective further couplers (32) by a single mode optical fibre (34). The further couplers (32) are asymmetric couplers having high tap-on coupling from the single mode optical fibre (34) to the respective uplead fibre (14, 16) but low tap-off coupling from the uplead fibre (14, 16).

Abstract: An optical sensor includes elongate light transmission means such as an optical fibre (13). A lens (16) of at least nearly half-pitch length is positioned with one of its focal planes substantially at a mouth (13a) of the optical fibre to receive and focus a diverging cone of light emergent therefrom. A reflector (20) is disposed substantially at another focal plane of the lens to reflect the focused light back to the mouth of the fibre. Detection means (14) in the path of the light between the mouth and the reflector is arranged to influence the light in response to an external condition in a manner whereby the reflected light received back at the fibre mouth may be monitored to detect the influence and thereby the condition. An optical fibre network has an incident fibre (40) and a detection fibre (42) coupled to plural optical components (60) via respective optical fibres (62) associated with the components and one or more optical fibre couplers (64, 68, 69).