Abstract: The present invention relates to new aptamer molecules for use in therapy of infections caused by viruses from the Coronaviridae family, a method of preventing infection caused by viruses from the Coronaviridae family in vitro/ex vivo, a pharmaceutical composition and a kit comprising such aptamer molecules, and the use of aptamer molecules for preventing infection of somatic cells with a virus from the Coronaviridae family. The present invention also relates to affinity molecules binding to specific and newly identified epitopes of a key enzyme of Coronaviridae viruses.

Abstract: Method for controlling an assist pump for fluid delivery systems with pulsatile pressure. If for example a heart assist pump is driven with a constant number of revolutions, it is achieved, that the blood is also delivered through the assist pump, even when the heart chamber is in the decontraction phase. With the present method it is achieved, that an assist pump only acts supportingly in the pressure phase of the main pump, in such a way, that the pressure difference between the input side and the output side of the assist pump is continuously determined and the number of revolutions of the assist pump is controlled in such a way, that the determined pressure difference does not fall below a predetermined value and the rate of flow does not sink below zero.