Patents by Inventor Peter G. Zaphiropoulos

Peter G. Zaphiropoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Basal cell carcinoma tumor suppressor protein
    Patent number: 7317086
    Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: January 8, 2008
    Assignee: United States of America as represented by the Department of Health and Human Services
    Inventors: Michael C. Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G. Zaphiropoulos, Mae R. Gailani, Susan M. Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne B. Unden, Susan A. Gilles, Kylie Negus, Ian McLeod Smyth, Carol L. Pressman, David J. Leffell, Bernard Gerrard, Alisa M. Goldstein, Brandon Wainwright, Rune C. M. Toftgard, Georgia Chenevix-Trench, Allen E. Bale
  • Component in the hedgehog signalling pathway
    Patent number: 6881833
    Abstract: The present invention relates to a novel human patched-like gene (PTCH2), which for the first time has been cloned and sequenced. Several alternatively spliced mRNA forms of PTCH2 have been identified, including transcripts lacking segments thought to be involved in sonic hedgehog (SHH) binding and mRNAs with differentially defined 3? terminal exons. Further, the invention also relates to the protein encoded by the present PTCH2 as well as to functional analogues and variants thereof.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: April 19, 2005
    Assignees: Karolinska Innovations AB, Pharmacia & Upjohn Company
    Inventors: Peter G. Zaphiropoulos, Anne Birgitte Unden, Rune Toftgård, Fahimeh Rahnama, Robert E. Hollingsworth
  • Novel component in the hedgehog signalling pathway
    Publication number: 20040146929
    Abstract: The present invention relates to a novel human patched-like gene (PTCH2), which for the first time has been cloned and sequenced. Several alternatively spliced mRNA forms of PTCH2 have been identified, including transcripts lacking segments thought to be involved in sonic hedgehog (SHH) binding and mRNAs with differentially defined 3′ terminal exons. Further, the invention also relates to the protein encoded by the present PTCH2 as well as to functional analogues and variants thereof.
    Type: Application
    Filed: March 4, 2004
    Publication date: July 29, 2004
    Applicant: Karolinska Innovations AB and Pharmacia & Upjohn Company
    Inventors: Peter G. Zaphiropoulos, Anne Birgitte Unden, Rune Toftgard, Fahimeh Rahnama, Robert E. Hollingsworth
  • Basal cell carcinoma tumor suppressor gene
    Publication number: 20030171566
    Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.
    Type: Application
    Filed: November 22, 2002
    Publication date: September 11, 2003
    Inventors: Michael Carlton Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G. Zaphiropoulos, Mae R. Gailani, Susan Mary Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne Birgitte Unden, Susan Alana Gillies, Kylie Negus, Ian McLeod Smyth, Carol Leah Pressman, David J. Leffell, Bernard Gerrard, Alisa Miriam Goldstein, Brandon Wainwright, Rune Carl Magnus Toftgard, Georgia Chenevix-Trench, Allen E. Bale
  • Basal cell carcinoma tumor supressor gene
    Patent number: 6552181
    Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: April 22, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael Carlton Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G Zaphiropoulos, Mae R. Gailani, Susan Mary Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne Birgitte Unden, Susan Alana Gillies, Kylie Negus, Ian Mcleod Smyth, Carol Leah Pressman, David J. Leffell, Bernard Gerrard, Alisa Miriam Goldstein, Brandon Wainwright, Rune Carl-Magnus Toftgard, Georgia Chenevix-Trench, Allen E. Bale
  • Molecules associated with the human suppressor of fused gene
    Patent number: 6448020
    Abstract: The present invention relates to proteins, polypeptides and nucleotides related to the human homologue of the Drosophila suppressor of fused gene, which is involved in the transduction of signals in the HH-PTC pathway. The invention also relates to antibodies raised against the polypeptides according to the invention. The molecules according to the present invention are useful in diagnostic and therapeutic methods relating to conditions associated with defects in said pathway, especially certain malformations and cancer. Other fields of application of the molecules according to the invention are e.g. studies of embryonic development, gene transcription and tissue repair.
    Type: Grant
    Filed: August 21, 2000
    Date of Patent: September 10, 2002
    Inventors: Rune Toftgard, Peter G. Zaphiropoulos, Priit Kogerman, Thomas Grimm