Abstract: A delay device includes a tuning network including first and second tuning components having frequency responses that overlap in an intermediate frequency band to provide a group delay response. A delay modifier is in communication with the tuning network and configured to provide an offset frequency as an input to the tuning network, and to electronically adjust a group delay value associated with the group delay response by varying the offset frequency. The difference between a frequency of an input reference signal and a local oscillator frequency produced by the delay modifier is substantially equal to an intermediate frequency of the tuning network. The tuning network and the delay modifier cooperate to transpose the reference signal at the reference frequency down to the IF band before passing through the first and second delay lines, and back up to the RF band after passing through the first and second delay lines.

Abstract: Various beverage preparation systems, components, and methods are disclosed. In some embodiments, the system includes a brewer machine and a beverage pod. The brewer machine can include a brew chamber unit, which can receive the beverage pod. The brew chamber unit can be adapted to receive multiple beverage pod types. Some embodiments include a drawer that includes the brew chamber and that moves to present the brew chamber unit to a user. Certain embodiments include locking mechanisms.

Abstract: Various beverage preparation systems, components, and methods are disclosed. In some embodiments, the system includes a brewer machine and a beverage pod. The brewer machine can include a brew chamber unit, which can receive the beverage pod. The brew chamber unit can be adapted to receive multiple beverage pod types. Some embodiments include a drawer that includes the brew chamber and that moves to present the brew chamber unit to a user. Certain embodiments include locking mechanisms.

Abstract: Various beverage preparation systems, components, and methods are disclosed. In some embodiments, the system includes a brewer machine and a beverage pod. The brewer machine can include a brew chamber unit, which can receive the beverage pod. The brew chamber unit can be adapted to receive multiple beverage pod types. Some embodiments include a drawer that includes the brew chamber and that moves to present the brew chamber unit to a user. Certain embodiments include locking mechanisms.

Abstract: Various beverage preparation systems, components, and methods are disclosed. In some embodiments, the system includes a brewer machine and a beverage pod. The brewer machine can include a brew chamber unit, which can receive the beverage pod. The brew chamber unit can be adapted to receive multiple beverage pod types. Some embodiments include a drawer that includes the brew chamber and that moves to present the brew chamber unit to a user. Certain embodiments include locking mechanisms.

Abstract: Various beverage preparation systems, components, and methods are disclosed. In some embodiments, the system includes a brewer machine and a beverage pod. The brewer machine can include a brew chamber unit, which can receive the beverage pod. The brew chamber unit can be adapted to receive multiple beverage pod types. Some embodiments include a drawer that includes the brew chamber and that moves to present the brew chamber unit to a user. Certain embodiments include locking mechanisms.

Abstract: Various beverage preparation systems, components, and methods are disclosed. In some embodiments, the system includes a brewer machine and a beverage pod. The brewer machine can include a brew chamber unit, which can receive the beverage pod. The brew chamber unit can be adapted to receive multiple beverage pod types. Some embodiments include a drawer that includes the brew chamber and that moves to present the brew chamber unit to a user. Certain embodiments include locking mechanisms.

Abstract: The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.

Abstract: The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.

Abstract: The present invention relates to methods for treating cancer comprising administering a combination of a liposomal platinum complex and one or more additional anticancer agents, pharmaceutical compositions comprising a liposomal platinum complex and one or more additional anticancer agents, and kits comprising unit doses of a liposomal platinum complex and one or more additional anticancer agents.

Abstract: The present invention relates to methods for treating cancer comprising administering a combination of 5-fluorouracil or a derivative thereof and a liposomal platinum complex. Pharmaceutical compositions comprising 5-fluorouracil or a derivative thereof and a liposomal platinum complex, and kits comprising unit doses of 5-fluorouracil or a derivative thereof and liposomal platinum complex.

Abstract: The present invention relates to methods for treating cancer comprising administering a combination of gemcitabine and a liposomal platinum complex, pharmaceutical compositions comprising gemcitabine and a liposomal platinum complex, and kits comprising unit dosage forms of gemcitabine and a liposomal platinum complex.

Abstract: The present invention relates to methods for treating cancer comprising administering a combination of capecitabine and a liposomal platinum complex, pharmaceutical compositions comprising capecitabine and a liposomal platinum complex, and kits comprising unit dosage forms of capecitabine and a liposomal platinum complex.

Abstract: An oxygen delivery apparatus includes a pneumatic conserving device which uses a portion of gas exiting its main valve to interrupt delivery of the gas. Gas is dispensed upon inhalation and is interrupted by means of suitable pneumatic connections between the device's delivery system and its sensing system. In some versions, the apparatus comprises an oxygen concentrator and the conserving device operates to deliver oxygen generated by the concentrator upon inhalation, and interrupts such delivery substantially independently of exhalation.

Abstract: A wireless terminal with virtual memory for use in a wireless communications network and a method of using such a wireless terminal is provided. The wireless terminal comprises a transceiver for receiving and transmitting information over an active wireless link with the communications network, virtual memory to store information received over the wireless link with the communications network and display means to view the information stored in the virtual memory without requiring the active wireless link with the communications network. The method of using the wireless terminal with virtual memory comprises the steps of downloading data from a server over an active wireless link to the virtual memory of the wireless terminal and accessing the data stored in the virtual memory at the wireless terminal without requiring the active wireless link.

Abstract: A portable, cryogenic gas delivery apparatus includes a chamber which contains cryogenic material, such as oxygen, in both liquid and gas phases. A probe is mounted to move relative to the chamber in response to variations in pressure in the gas phase within the chamber. The probe has one part positioned within the chamber so that it is exposed to the pressure and temperature of the gas within the chamber and a second part located outside the chamber. The probe thus introduces heat from the ambient into the chamber. The probe preferably moves relative to the chamber in response to variations in pressure, moving away from the chamber to reduce the amount of thermal energy introduced into the chamber and toward the chamber to increase the amount of thermal energy introduced into the chamber. The apparatus includes a conserver which receives gas evaporating from the chamber and delivers it in efficient pulses to the end user in response to the user's inhalation.