Abstract: A system for monitoring autoregulation includes an oxygen saturation sensor configured to obtain an oxygen saturation signal indicative of an oxygen saturation of a patient. The system also includes a controller having a processor configured to receive a blood pressure signal indicative of a blood pressure of the patient and the oxygen saturation signal, determine a change in the oxygen saturation signal and a change in the blood pressure signal over a period of time, and provide an indication that the patient's autoregulation is intact if the oxygen saturation changes by more than an oxygen saturation threshold and if the blood pressure changes by less than a blood pressure threshold during the period of time.

Abstract: A system for monitoring autoregulation includes an oxygen saturation sensor configured to obtain an oxygen saturation signal indicative of an oxygen saturation of a patient. The system also includes a controller having a processor configured to receive a blood pressure signal indicative of a blood pressure of the patient and the oxygen saturation signal, determine a change in the oxygen saturation signal and a change in the blood pressure signal over a period of time, and provide an indication that the patient's autoregulation is intact if the oxygen saturation changes by more than an oxygen saturation threshold and if the blood pressure changes by less than a blood pressure threshold during the period of time.

Abstract: Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the bound complex to migrate toward the electrode with opposite charge of the bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the bound complex band and one or both of the migration pattern and the migration velocity.

Abstract: The disclosed methods and systems use multi-spectral imaging of band data in point-of-care devices during active electrophoresis test runs to detect sensitive disease state compounds, such as hemoglobin and its variants and sub-variants. The multi-spectral imaging identifies an imaging wavelength of light that, when emitted towards the electrophoresis strip, optimizes images of the electrophoresis strip that are captured during the test. These optimized images allow for detection of the target compound, particularly at low concentrations and with low limits of detection (LoD).

Abstract: Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound and a label. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex or “bound complex” with the label is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the labeled bound complex to migrate toward the electrode with opposite charge of the labeled bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the labeled bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the labeled bound complex band and one or both of the migration pattern and the migration velocity.

Abstract: A diagnostic system that includes a cartridge and a reader is discussed herein. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease, or infection of the patient.

Abstract: A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease and/or infection of the patient.

Abstract: A diagnostic system that includes a cartridge and a reader is discussed herein. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease, or infection of the patient.

Abstract: A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease and/or infection of the patient.

Abstract: A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as a magneto-optical system that measures a light transmission differential through the patient sample in varying magnetic fields. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disease, infection and/or condition of the patient.

Abstract: A diagnostic system detects and/or measures hemoglobin variants in blood of subject, such as HbA1c, to determine blood glucose concentration in the subject.

Abstract: A diagnostic system detects and/or measures hemoglobin variants in blood of subject, such as HbA1c, to determine blood glucose concentration in the subject.

Abstract: A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The sample can be processed for data collection and analysis to provide interpretative results indicative of a disorder, condition, disease and/or infection of the patient. For example, the data collection and analysis can differentiate between two or more species capable of causing or actually causing a parasitic infection.

Abstract: Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound and a label. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex or “bound complex” with the label is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the labeled bound complex to migrate toward the electrode with opposite charge of the labeled bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the labeled bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the labeled bound complex band and one or both of the migration pattern and the migration velocity.

Abstract: Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound and a label. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex or “bound complex” with the label is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the labeled bound complex to migrate toward the electrode with opposite charge of the labeled bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the labeled bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the labeled bound complex band and one or both of the migration pattern and the migration velocity.

Abstract: A circuit for preventing sparks. The circuit having a power storage component having a first power storage end and a second power storage end; a power source electrically connected to the power storage component, the power source having a first power source end and a second power source end; a first current directional component electrically connected to the power storage component and having a first current direction; a first power absorption component electrically connected to the power storage component and having a current direction, the first current directional component and the first power absorption component being electrically connected to the power storage component in parallel; and at least one switch electrically connected to the power storage component.

Abstract: A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The sample can be processed for data collection and analysis to provide interpretative results indicative of a disorder, condition, disease and/or infection of the patient. Processing can include external sonication and conjugating non-magnetic target material with magnetic nanoparticles and non-magnetic solids.

Abstract: Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound and a label. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex or “bound complex” with the label is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the labeled bound complex to migrate toward the electrode with opposite charge of the labeled bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the labeled bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the labeled bound complex band and one or both of the migration pattern and the migration velocity.

Abstract: A diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The sample can be processed for data collection and analysis to provide interpretative results indicative of a disorder, condition, disease or infection of the patient. For example, the data collection and analysis can determine one or more hemozoin characteristics.