Patents by Inventor Peter Gareiss

Peter Gareiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PanK Modulators and Methods Using Same
    Publication number: 20230242538
    Abstract: The disclosure relates, in certain aspects, to the discovery of certain compounds that are useful to treat and/or prevent fungal infections in a subject. The disclosure further relates, in certain aspects, to the discovery of certain compounds that are useful are useful for treating, ameliorating, and/or preventing diseases or disorders associated with reduced and/or deficient PanK activity in a subject. In certain embodiments, the disease or disorder comprises a neurodegenerative disease, such as but not limited to pantothenate kinase-associated neurodegeneration (PKAN).
    Type: Application
    Filed: June 23, 2021
    Publication date: August 3, 2023
    Inventors: Choukri Ben Mamoun, Peter Gareiss, Jose Thekkiniath, Denton Hoyer, Yulia Surovtseva, William Hungerford, Mark Plummer, Antonella Stroppa, Joy Chiu
  • MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE
    Publication number: 20210261516
    Abstract: Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.
    Type: Application
    Filed: May 3, 2021
    Publication date: August 26, 2021
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, Yale University
    Inventors: John Schneekloth, JR., John Simmons, Kenneth Felsenstein, Beverly Mock, Lindsey Saunders, Peter Gareiss, David Calabrese, Elena Leon
  • Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) Histone Demethylase
    Publication number: 20190151289
    Abstract: The present invention includes novel inhibitors of JARID1A demethylase activity, and methods using the same.
    Type: Application
    Filed: May 12, 2017
    Publication date: May 23, 2019
    Inventors: Qin Yan, Molly Gale, Denton Hoyer, Joyce Sayegh, Jian Cao, Peter Gareiss
  • MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE
    Publication number: 20190100503
    Abstract: Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 4, 2019
    Applicants: The United States of America as represented by the Secretary, Department of Health and Human Service, Yale University
    Inventors: John Schneekloth, JR., John Simmons, Kenneth Felsenstein, Beverly Mock, Lindsey Saunders, Peter Gareiss, David Calabrese, Elena Leon
  • MYC G-quadruplex stabilizing small molecules and their use
    Patent number: 10196372
    Abstract: Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: February 5, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Yale University
    Inventors: John Schneekloth, Jr., John Simmons, Kenneth Felsenstein, Beverly Mock, Lindsey Saunders, Peter Gareiss, David Calabrese, Elena Leon
  • MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE
    Publication number: 20180030018
    Abstract: Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.
    Type: Application
    Filed: January 5, 2016
    Publication date: February 1, 2018
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, Yale University
    Inventors: John Schneekloth, JR., John Simmons, Kenneth Felsenstein, Beverly Mock, Lindsey Saunders, Peter Gareiss, David Calabrese, Elena Leon
  • SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION
    Publication number: 20160009652
    Abstract: The present invention relates to small molecule modulators of melanin expression and methods of making the small molecules. Also disclosed are methods of increasing pigmentation in a cell which involve providing compounds of the present invention and contacting a cell with the compounds under conditions effective to induce melanin expression in the cell, thereby increasing pigmentation. The present invention also relates to compositions containing compounds of the present invention and a carrier.
    Type: Application
    Filed: September 22, 2015
    Publication date: January 14, 2016
    Inventors: Benjamin L. Miller, Brian R. McNaughton, Peter Gareiss, Glynis Scott
  • Small-molecule modulators of melanin expression
    Patent number: 9162984
    Abstract: The present invention relates to small molecule modulators of melanin expression and methods of making the small molecules. Also disclosed are methods of increasing pigmentation in a cell which involve providing compounds of the present invention and contacting a cell with the compounds under conditions effective to induce melanin expression in the cell, thereby increasing pigmentation. The present invention also relates to compositions containing compounds of the present invention and a carrier.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: October 20, 2015
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Brian R. McNaughton, Peter Gareiss, Glynis Scott
  • SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION
    Publication number: 20100233106
    Abstract: The present invention relates to small molecule modulators of melanin expression and methods of making the small molecules. Also disclosed are methods of increasing pigmentation in a cell which involve providing compounds of the present invention and contacting a cell with the compounds under conditions effective to induce melanin expression in the cell, thereby increasing pigmentation. The present invention also relates to compositions containing compounds of the present invention and a carrier.
    Type: Application
    Filed: March 28, 2008
    Publication date: September 16, 2010
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Benjamin L. Miller, Brian R. McNaughton, Peter Gareiss, Glynis Scott